190 research outputs found
The electrical pulse duplicator-its use in testing valve prostheses with special reference to the aortic and mitral valves
No Abstrac
Observations on the early diagnosis and chemotherapeutic treatment of threatened renal rejection in dogs
No Abstract
Recommended from our members
Estimates of energy fluence at the focal plane in beams undergoing neutralized drift compression
The authors estimate the energy fluence (energy per unit area) at the focal plane of a beam undergoing neutralized drift compression and neutralized solenoidal final focus, as is being carried out in the Neutralized Drift Compression Experiment (NDCX) at LBNL. In these experiments, in order to reach high beam intensity, the beam is compressed longitudinally by ramping the beam velocity (i.e. introducing a velocity tilt) over the course of the pulse, and the beam is transversely focused in a high field solenoid just before the target. To remove the effects of space charge, the beam drifts in a plasma. The tilt introduces chromatic aberrations, with different slices of the original beam having different radii at the focal plane. The fluence can be calculated by summing the contribution from the various slices. They develop analytic formulae for the energy fluence for beams that have current profiles that are initially constant in time. They compare with envelope and particle-in-cell calculations. The expressions derived are useful for predicting how the fluence scales with accelerator and beam parameters
Towards developing multiscale-multiphysics models and their surrogates for digital twins of metal additive manufacturing
Artificial intelligence (AI) embedded within digital models of manufacturing processes can be used to improve
process productivity and product quality significantly. The application of such advanced capabilities particularly
to highly digitalized processes such as metal additive manufacturing (AM) is likely to make those processes
commercially more attractive. AI capabilities will reside within Digital Twins (DTs) which are living virtual
replicas of the physical processes. DTs will be empowered to operate autonomously in a diagnostic control capacity to supervise processes and can be interrogated by the practitioner to inform the optimal processing route
for any given product. The utility of the information gained from the DTs would depend on the quality of the
digital models and, more importantly, their faster-solving surrogates which dwell within DTs for consultation
during rapid decision-making. In this article, we point out the exceptional value of DTs in AM and focus on the
need to create high-fidelity multiscale-multiphysics models for AM processes to feed the AI capabilities. We
identify technical hurdles for their development, including those arising from the multiscale and multiphysics
characteristics of the models, the difficulties in linking models of the subprocesses across scales and physics, and
the scarcity of experimental data. We discuss the need for creating surrogate models using machine learning
approaches for real-time problem-solving. We further identify non-technical barriers, such as the need for
standardization and difficulties in collaborating across different types of institutions. We offer potential solutions
for all these challenges, after reflecting on and researching discussions held at an international symposium on the
subject in 2019. We argue that a collaborative approach can not only help accelerate their development
compared with disparate efforts, but also enhance the quality of the models by allowing modular development
and linkages that account for interactions between the various sub-processes in AM. A high-level roadmap is
suggested for starting such a collaboration.The main
sponsor of the Symposium was the CSIRO Research Office. Co-sponsors
were The University of Melbourne, RMIT University, and the software
companies associated with ThingWorx, Solvia, MSC Simufact, Materialise and Flow-3D
Avaliação preliminar de óleos essenciais de plantas como repelentes para Aedes albopictus (Skuse, 1894) (Diptera: Culicidae)
Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy
We review HB stars in a broad astrophysical context, including both variable
and non-variable stars. A reassessment of the Oosterhoff dichotomy is
presented, which provides unprecedented detail regarding its origin and
systematics. We show that the Oosterhoff dichotomy and the distribution of
globular clusters (GCs) in the HB morphology-metallicity plane both exclude,
with high statistical significance, the possibility that the Galactic halo may
have formed from the accretion of dwarf galaxies resembling present-day Milky
Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the
second-parameter problem is presented. A technique is proposed to estimate the
HB types of extragalactic GCs on the basis of integrated far-UV photometry. The
relationship between the absolute V magnitude of the HB at the RR Lyrae level
and metallicity, as obtained on the basis of trigonometric parallax
measurements for the star RR Lyrae, is also revisited, giving a distance
modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are
studied. Finally, the conductive opacities used in evolutionary calculations of
low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and
Space Scienc
Gene-gene Interaction Analyses for Atrial Fibrillation
Atrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene interaction on AF susceptibility. We performed a large-scale association analysis of gene-gene interactions with AF in 8,173 AF cases, and 65,237 AF-free referents collected from 15 studies for discovery. We examined putative interactions between genome-wide SNPs and 17 known AF-related SNPs. The top interactions were then tested for association in a
Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium
It is unclear whether genetic markers interact with risk factors to influence atrial fibrillation (AF) risk. We performed genome-wide interaction analyses between genetic variants and age, sex, hypertension, and body mass index in the AFGen Consortium. Study-specific results were combined using meta-analysis (88,383 individuals of European descent, including 7,292 with AF). Variants with nominal interaction associations in the discovery analysis were tested for association in four independent studies (131,441 individuals, including 5,722 with AF). In the discovery analysis, the AF risk associated with the minor rs6817105 allele (at the PITX2 locus) was greater among subjects ≤ 65 years of age than among those > 65 years (interaction p-value = 4.0 × 10-5). The interaction p-value exceeded genome-wide significance in combined discovery and replication analyses (interaction p-value = 1.7 × 10-8). We observed one genome-wide significant interaction with body mass index and several suggestive interactions with age, sex, and body mass index in the discovery analysis. However, none was replicated in the independent sample. Our findings suggest that the pathogenesis of AF may differ according to age in individuals of European descent, but we did not observe evidence of statistically significant genetic interactions with sex, body mass index, or hypertension on AF risk
Recommended from our members
Energetic particle influence on the Earth's atmosphere
This manuscript gives an up-to-date and comprehensive overview of the effects of energetic particle precipitation (EPP) onto the whole atmosphere, from the lower thermosphere/mesosphere through the stratosphere and troposphere, to the surface. The paper summarizes the different sources and energies of particles, principally
galactic cosmic rays (GCRs), solar energetic particles (SEPs) and energetic electron precipitation (EEP). All the proposed mechanisms by which EPP can affect the atmosphere
are discussed, including chemical changes in the upper atmosphere and lower thermosphere, chemistry-dynamics feedbacks, the global electric circuit and cloud formation. The role of energetic particles in Earth’s atmosphere is a multi-disciplinary problem that requires expertise from a range of scientific backgrounds. To assist with this synergy, summary tables are provided, which are intended to evaluate the level of current knowledge of the effects of energetic particles on processes in the entire atmosphere
Effect of aliskiren on post-discharge outcomes among diabetic and non-diabetic patients hospitalized for heart failure: insights from the ASTRONAUT trial
Aims The objective of the Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT) was to determine whether aliskiren, a direct renin inhibitor, would improve post-discharge outcomes in patients with hospitalization for heart failure (HHF) with reduced ejection fraction. Pre-specified subgroup analyses suggested potential heterogeneity in post-discharge outcomes with aliskiren in patients with and without baseline diabetes mellitus (DM). Methods and results ASTRONAUT included 953 patients without DM (aliskiren 489; placebo 464) and 662 patients with DM (aliskiren 319; placebo 343) (as reported by study investigators). Study endpoints included the first occurrence of cardiovascular death or HHF within 6 and 12 months, all-cause death within 6 and 12 months, and change from baseline in N-terminal pro-B-type natriuretic peptide (NT-proBNP) at 1, 6, and 12 months. Data regarding risk of hyperkalaemia, renal impairment, and hypotension, and changes in additional serum biomarkers were collected. The effect of aliskiren on cardiovascular death or HHF within 6 months (primary endpoint) did not significantly differ by baseline DM status (P = 0.08 for interaction), but reached statistical significance at 12 months (non-DM: HR: 0.80, 95% CI: 0.64-0.99; DM: HR: 1.16, 95% CI: 0.91-1.47; P = 0.03 for interaction). Risk of 12-month all-cause death with aliskiren significantly differed by the presence of baseline DM (non-DM: HR: 0.69, 95% CI: 0.50-0.94; DM: HR: 1.64, 95% CI: 1.15-2.33; P < 0.01 for interaction). Among non-diabetics, aliskiren significantly reduced NT-proBNP through 6 months and plasma troponin I and aldosterone through 12 months, as compared to placebo. Among diabetic patients, aliskiren reduced plasma troponin I and aldosterone relative to placebo through 1 month only. There was a trend towards differing risk of post-baseline potassium ≥6 mmol/L with aliskiren by underlying DM status (non-DM: HR: 1.17, 95% CI: 0.71-1.93; DM: HR: 2.39, 95% CI: 1.30-4.42; P = 0.07 for interaction). Conclusion This pre-specified subgroup analysis from the ASTRONAUT trial generates the hypothesis that the addition of aliskiren to standard HHF therapy in non-diabetic patients is generally well-tolerated and improves post-discharge outcomes and biomarker profiles. In contrast, diabetic patients receiving aliskiren appear to have worse post-discharge outcomes. Future prospective investigations are needed to confirm potential benefits of renin inhibition in a large cohort of HHF patients without D
- …