Consequences of Deploying Culturally Inclined Earcons in Speech Technology Design for Oral Users in South Africa

ABSTRACT We discuss the qualitative outcomes of utilizing an earcon in the design of an Interactive Voice Response (IVR) system. Earcons are short non-speech audio messages that are used in the computer/user interface (UI) to provide information to the user about some computer object, operation or interactio

Bluetongue in Captive Yaks

In August 2006, several Northern European countries including Belgium reported their first cases of bluetongue (BT). Surprisingly, it was the first time that BT was diagnosed so far in the northern hemisphere (1). BT is a non contagious, arthropod borne animal disease. The causal virus belongs to the genus Orbivirus in the family Reoviridae. The genome of the bluetongue virus (BTV) consists of 10 segments of double-stranded RNA and 24 serotypes have been reported (2). Serotype 8 (BTV-8) was implied in the emergence in Belgium (3). All ruminant species are thought to be susceptible to BT (2) but lack of data remains for certain species. We report here laboratory confirmed clinical cases of BT in yaks

The Spoken Web Search Task

International audienceIn this paper, we describe the "Spoken Web Search" Task, which is being held as part of the 2012 MediaEval campaign. The purpose of this task is to perform audio search in multiple languages, with very little resources being available for each individual language. The data is being taken from audio content that was created in live and realistic low-resource settings

Learning Structured Representations of Data

Abstract Bayesian networks have shown themselves to be useful tools for the analysis and modelling of large data sets. However, their complete generality leads to computational and modelling complexities that have limited their applicability. We propose an approach to simplify and constrain Bayesian networks that strikes a more useful compromise between generality and tractability. These constrained graphical will allow us to build computationally tractable models for large high-dimensional data sets. We also describe examples of data sets drawn from image and speech processing on which we can (1) further explore this constrained set of graphical models, and (2) analyse their performance as a general-purpose statistical data analysis tool

Spatial heterogeneity in the paraglacial response to post-Little Ice Age deglaciation of four headwater cirques in the Western Alps

International audienceThis paper aims to understand how the paraglacial response to recent glacier retreat varies between four cirques in the Western Alps. Post‐Little Ice Age glacier retreat has created extensive forelands where a variety of gravitational and fluvial process operate on both till‐floored and rock‐floored cirques. These processes may affect transitions from subglacial to proglacial landsystems, by reworking sediment and reorganising drainage. Landsystems achieve a state of preservation once no more adjustment is possible due to buffering by channel network evolution, channel armouring, and sediment exhaustion. We find no consistent trajectory of change across all studied sites: paraglacial responses differ from the classical valley–glacier model, involving variable slope‐channel coupling. Proglacial drainage networks on till surfaces have become more integrated by reducing their low‐order bifurcation ratios, unlike streams locked into rock channels. Reasons for diverse and site‐specific behaviour include cirque floor width, gradient, and surface materials (bedrock, fine till, and/or blocky till). At some cirques, these restrict the downstream diffusion of a paraglacial “signal” of fluvial‐transported sediment. At others, increased sediment flux originated from the erosion of terminal moraines. A high proportion of glacial material generally remains within the glacier foreland, due to proglacial basin sediment traps, inefficiency of fluvial networks, armouring of floors by coarse tills, and rock‐controlled channels. The millennial‐timescale preservation potential of most recent primary glacial deposits and within‐cirque paraglacial landforms appears to be hig

Fanny Copeland and the geographical imagination

Raised in Scotland, married and divorced in the English south, an adopted Slovene, Fanny Copeland (1872 – 1970) occupied the intersection of a number of complex spatial and temporal conjunctures. A Slavophile, she played a part in the formation of what subsequently became the Kingdom of Yugoslavia that emerged from the First World War. Living in Ljubljana, she facilitated the first ‘foreign visit’ (in 1932) of the newly formed Le Play Society (a precursor of the Institute of British Geographers) and guided its studies of Solčava (a then ‘remote’ Alpine valley system) which, led by Dudley Stamp and commended by Halford Mackinder, were subsequently hailed as a model for regional studies elsewhere. Arrested by the Gestapo and interned in Italy during the Second World War, she eventually returned to a socialist Yugoslavia, a celebrated figure. An accomplished musician, linguist, and mountaineer, she became an authority on (and populist for) the Julian Alps and was instrumental in the establishment of the Triglav National Park. Copeland’s role as participant observer (and protagonist) enriches our understanding of the particularities of her time and place and illuminates some inter-war relationships within G/geography, inside and outside the academy, suggesting their relative autonomy in the production of geographical knowledge

Intracellular cyclic adenosine monophosphate regulates the efficiency of intercellular transmission of human T-lymphotropic virus type I

Objective To investigate the relationship between the intercellular transmission efficiency of human T-lymphotropic virus type I (HTLV-I) and the signaling involved in actin polymerization during cytoskeletal reorganization in a comparative study of HTLV-I-infected T-cell lines derived from an HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient or an HTLV-I carrier. Methods HCT-5 and TL-Su cells derived from an HAM/TSP patient and an HTLV-I carrier, respectively, were used as HTLV-I-infected T-cell lines. After co-cultivation of each HTLV-I-infected T-cell line with H9/K30 luc reporter cells, the relative luc activities were calculated to analyze the efficiency of intercellular transmission of HTLV-I. The intracellular levels of cyclic adenosine monophosphate (cAMP) or cyclic guanosine monophosphate (cGMP) were measured in enzyme-linked immunoassays. The expression of phosphorylated vasodilator-stimulated phosphoprotein (p-VASP) was analyzed by western blotting. Results Treatment of HCT-5 cells with latrunculin B, an inhibitor of actin polymerization, significantly suppressed the relative luc activity. Western blotting analysis of HCT-5 cells treated with the adenylyl cyclase activator forskolin showed upregulation of p-VASP, with a concomitant and significant increase in the intracellular cAMP concentration. Furthermore, the relative luc activity was significantly decreased. The intracellular cAMP, but not cGMP levels, were significantly lower in HCT-5 than in TL-Su. Vasodilator-stimulated phosphoprotein appeared less phosphorylated in HCT-5 than in TL-Su. The relative luc activity was significantly higher in HCT-5 than in TL-Su. Conclusions The intracellular cAMP concentration regulates the efficiency of intercellular HTLV-I transmission under the control of p-VASP expression, suggesting the intercellular transmission potential of HTLV-I-infected T cells of HAM/TSP patients is enhanced by downregulated intracellular cAMP levels

Centrosome docking at the immunological synapse is controlled by Lck signaling.

Docking of the centrosome at the plasma membrane directs lytic granules to the immunological synapse. To identify signals controlling centrosome docking at the synapse, we have studied cytotoxic T lymphocytes (CTLs) in which expression of the T cell receptor-activated tyrosine kinase Lck is ablated. In the absence of Lck, the centrosome is able to translocate around the nucleus toward the immunological synapse but is unable to dock at the plasma membrane. Lytic granules fail to polarize and release their contents, and target cells are not killed. In CTLs deficient in both Lck and the related tyrosine kinase Fyn, centrosome translocation is impaired, and the centrosome remains on the distal side of the nucleus relative to the synapse. These results show that repositioning of the centrosome in CTLs involves at least two distinct steps, with Lck signaling required for the centrosome to dock at the plasma membrane