Development and application of a local linearization algorithm for the integration of quaternion rate equations in real-time flight simulation problems

High angular rates encountered in real-time flight simulation problems may require a more stable and accurate integration method than the classical methods normally used. A study was made to develop a general local linearization procedure of integrating dynamic system equations when using a digital computer in real-time. The procedure is specifically applied to the integration of the quaternion rate equations. For this application, results are compared to a classical second-order method. The local linearization approach is shown to have desirable stability characteristics and gives significant improvement in accuracy over the classical second-order integration methods

Photometry, spectrophotometry and polarimetry of comet P/Encke during fall of 1979

Broadband S-20, B and V magnitudes of P/Encke were obtained with the digital area photometer, using an Image Dissector Scanner (IDS) detector on the 2.7 m telescope at McDonald Observatory during August 1979. The notation V(S-20) is used for S-20 magnitudes transformed to V magnitudes. The variation in the V(S20) magnitudes (26, 5 minute integrations) on the best photometric night (21 August) was small and random indicating either a lack of rotational albedo variations or, more likely, a masking of the nucleus by the outburst activity. A spectrum covering the region from 3630 to 4900 A at a resolution of 5 A was obtained on 27 August with the IDS spectrograph. The spectrum was featureless, showing no emission at the CN or CO+ wavelengths

Financial interests of patient organisations contributing to technology appraisal at England's National Institute for Health and Care Excellence (NICE): a policy review

Objectives: To investigate the prevalence of financial interests among patient organisations contributing to health technology assessment at the National Institute for Health and Care Excellence (NICE) in England, and the extent to which current disclosure policy ensures decision-making committees are aware of these interests. Design: Policy review using annual accounts, reports and websites of patient organisations, a database of payments declared by pharmaceutical manufacturers (Disclosure UK), other manufacturer declarations, responses from patient organisations, and declarations of interests by nominated representatives of patient organisations. Setting: Appraisals of medicines and treatments for use in the English and Welsh National Health Service. Participants: 53 patient organisations contributing to 41 NICE technology appraisals published in 2015 and 2016, with 117 separate occasions that a patient organisation contributed to the appraisal of a technology. Main outcome measures: (i) Prevalence of specific interests, i.e. funding from manufacturer(s) of a technology under appraisal or competitor products; (ii) Proportion of specific interests of which NICE decision-making committees were aware; (iii) Proportion of specific interests for which disclosure was not required by current NICE policy. Results: 38/53 (71.7%) patient organisations had accepted funding from the manufacturer(s) of a technology or a competitor product in the same or previous year that they had contributed to the appraisal of that technology. Specific interests were 46 present on 92 out of 117 (78.6%) occasions that patient organisations contributed to appraisals in 2015 and 2016. NICE decision-making committees were aware of less than a third of specific interests (36/115, 31.3%). For over half of the specific interests of which committees were unaware (42/79, 53.2%), disclosure by patient organisations was not required by current NICE policy. Conclusions: Specific interests are highly prevalent among patient organisations contributing to health technology assessment. NICE is reviewing its disclosure policy to ensure that decision-making committees are aware of all relevant interests

Combined EEG-fMRI and tractography to visualise propagation of epileptic activity

In a patient with refractory temporal lobe epilepsy, EEG-fMRI showed activation in association with left anterior temporal interictal discharges, in the left temporal, parietal and occipital lobes. Dynamic causal modelling suggested propagation of neural activity from the temporal focus to the area of occipital activation. Tractography showed connections from the site of temporal lobe activation to the site of occipital activation. This demonstrates the principle of combining EEG-fMRI and tractography to delineate the pathways of propagation of epileptic activity

The Lennard-Jones-Devonshire cell model revisited

We reanalyse the cell theory of Lennard-Jones and Devonshire and find that in addition to the critical point originally reported for the 12-6 potential (and widely quoted in standard textbooks), the model exhibits a further critical point. We show that the latter is actually a more appropriate candidate for liquid-gas criticality than the original critical point.Comment: 5 pages, 3 figures, submitted to Mol. Phy

Mutual Event Observations of Io's Sodium Corona

We have measured the column density profile of Io's sodium corona using 10 mutual eclipses between the Galilean satellites. This approach circumvents the problem of spatially resolving Io's corona directly from Io's bright continuum in the presence of atmospheric seeing and telescopic scattering. The primary goal is to investigate the spatial and temporal variations of Io's corona. Spectra from the Keck Observatory and McDonald Observatory from 1997 reveal a corona that is only approximately spherically symmetric around Io. Comparing the globally averaged radial sodium column density profile in the corona with profiles measured in 1991 and 1985, we find that there has been no significant variation. However, there appears to be a previously undetected asymmetry: the corona above Io's sub-Jupiter hemisphere is consistently more dense than above the anti-Jupiter hemisphere

Test and model correlation of the atmospheric emission photometric imager fiberglass pedestal

The correlation is presented of the static loads testing and finite element modeling for the fiberglass pedestal used on the Atmospheric Emission Photometric Imaging (AEPI) experiment. This payload is to be launched in the space shuttle as part of the ATLAS-1 experiment. Strain gauge data from rosettes around the highly loaded base are compared to the same load case run for the Spacelab 1 testing done in 1981. Correlation of the model and test data was accomplished through comparison of the composite stress invariant using the expected flight loads for the ATLAS-1 mission. Where appropriate, the Tsai-Wu failure criteria was used in the development of the key margins of safety. Margins of safety are all positive for the pedestal and are reported

STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection.

UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent type I IFN response in infected cells, yet the IFN-inducing ligand remains unknown. In this report, we provide evidence that Chlamydia synthesizes cyclic di-AMP (c-di-AMP), a nucleic acid metabolite not previously identified in Gram-negative bacteria, and that this metabolite is a prominent ligand for STING-mediated activation of IFN responses during infection. We used primary mouse lung fibroblasts and HEK293T cells to compare IFN-β responses to Chlamydia infection, c-di-AMP, and other type I IFN-inducing stimuli. Chlamydia infection and c-di-AMP treatment induced type I IFN responses in cells expressing STING but not in cells expressing STING variants that cannot sense cyclic dinucleotides but still respond to cytoplasmic DNA. The failure to induce a type I IFN response to Chlamydia and c-di-AMP correlated with the inability of STING to relocalize from the endoplasmic reticulum to cytoplasmic punctate signaling complexes required for IFN activation. We conclude that Chlamydia induces STING-mediated IFN responses through the detection of c-di-AMP in the host cell cytosol and propose that c-di-AMP is the ligand predominantly responsible for inducing such a response in Chlamydia-infected cells.ImportanceThis study shows that the Gram-negative obligate pathogen Chlamydia trachomatis, a major cause of pelvic inflammatory disease and infertility, synthesizes cyclic di-AMP (c-di-AMP), a nucleic acid metabolite that thus far has been described only in Gram-positive bacteria. We further provide evidence that the host cell employs an endoplasmic reticulum (ER)-localized cytoplasmic sensor, STING (stimulator of interferon [IFN] genes), to detect c-di-AMP synthesized by Chlamydia and induce a protective IFN response. This detection occurs even though Chlamydia is confined to a membrane-bound vacuole. This raises the possibility that the ER, an organelle that innervates the entire cytoplasm, is equipped with pattern recognition receptors that can directly survey membrane-bound pathogen-containing vacuoles for leaking microbe-specific metabolites to mount type I IFN responses required to control microbial infections

The 13N(d,n)14O Reaction and the Astrophysical 13N(p,g)14O Reaction Rate

$^{13}$N($p,\gamma$)$^{14}$O is one of the key reactions in the hot CNO cycle which occurs at stellar temperatures around $T_9$ $\geq$ 0.1. Up to now, some uncertainties still exist for the direct capture component in this reaction, thus an independent measurement is of importance. In present work, the angular distribution of the $^{13}$N($d,n$)$^{14}$O reaction at $E_{\rm{c.m.}}$ = 8.9 MeV has been measured in inverse kinematics, for the first time. Based on the distorted wave Born approximation (DWBA) analysis, the nuclear asymptotic normalization coefficient (ANC), $C^{^{14}O}_{1,1/2}$, for the ground state of $^{14}$O $\to$ $^{13}$N + $p$ is derived to be $5.42 \pm 0.48$ fm$^{-1/2}$. The $^{13}$N($p,\gamma$)$^{14}$O reaction is analyzed with the R-matrix approach, its astrophysical S-factors and reaction rates at energies of astrophysical relevance are then determined with the ANC. The implications of the present reaction rates on the evolution of novae are then discussed with the reaction network calculations.Comment: 17 pages and 8 figure

Ecological and socio-economic impacts of dive and snorkel tourism in St. Lucia, West Indies

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