1951 Ruby Yearbook

A digitized copy of the 1951 Ruby, the Ursinus College yearbook.https://digitalcommons.ursinus.edu/ruby/1053/thumbnail.jp

The Ursinus Weekly, October 3, 1949

First epistle to the freshmen • Fords to be rivals in home grid clash • Hockey drills start; Frick leads squad • Harriers condition for championships • Bruin eleven yields 21-0 as Drexel breaks streak • Greek prof begins seventeenth season as soccer mentor • Interdorm program set; includes tennis, football • Bears elect leader for grid campaign • Bakermen prepare for season opener • From the sidelines • Kunz, Nicholls go continental • Ursinus star shines in summer theater • Editorial: Senior to frosh • Six assume posts on Ursinus faculty • Forums to include verse and opinions on Arctic, Far East • Teachers j.g. begin trial flights soon • Y to present plans at rally Wednesday • Greenies view Ursinus under bands and bangs • School registers 974 as enrollment drops • WSGA begins duties as committees plan future coed events • Bruin brainmen hit dean\u27s squad 79-29 after 16-week fray • New prexy outlines semester schedule for musical groups • Campus store introduces new hours, coffee machine • President entertains at banquet • Juniors set freshman breakfasthttps://digitalcommons.ursinus.edu/weekly/1572/thumbnail.jp

The Ursinus Weekly, April 17, 1950

Junior prom to highlight week\u27s social calendar • Forum to present prominent explorer for monthly event • Students select leaders for WSGA, WAA, and Y • Senator to address PAC Wednesday • IRC group attends model UN assembly • French club plans April piano recital • ICG members help draft constitution • Scientists to participate in Y-sponsored panel • Practices continue for spring comedy • Board names six to Weekly editorial staff • Commission to discuss admittance of Negroes • \u27Waltz dream\u27 scores hit with Ursinus audiences • P.A.C. visits Washington on annually planned trip • Swedish books add variety to library language shelves • Alumnus suggests constitution change for alumni group • Three men and a rebel tour southland as vacation interrupts semester work • Ursinus welcomes new dance band • Grizzly nine tours south; trip is judged successful • Rampaging grizzlies open season with pair of wins • Tennis belles open against Bryn Mawr • Nine veterans back for softball season • Stine and Shreiner win men\u27s, girls\u27 intramurals • Gurzynski is named head football coach for 1950 • Annex wins honors on intramural night • Garris\u27 pageant selected for \u2750 May Day themehttps://digitalcommons.ursinus.edu/weekly/1589/thumbnail.jp

The Ursinus Weekly, January 8, 1951

Group attends NSA meeting during holiday • French Club conducts meeting and lists plans • Final examinations to continue January 18-26; Schedule posted • Chess Club to play • Rice to give talk on Atlantic Union • Sophomore class to sponsor square dance Friday night • President McClure issues statement on present draft situation at Ursinus • College offers new two-term Summer school • Graduate featured in magazine story • Curtain Club announces next group production • Students participate in television show • Forty attend Philly luncheon of Ursinus Women\u27s Club • New Rosicrucians feted • Miller appears on Quaker City TV University • Ursinus grad to hold state executive office • Opinions on Korea: Ursinus representatives speak their minds • Double-duty secretary gowns directors for processions, manages switchboard • Downpour predicted; Waterproof notes, dry textbooks, precautions prescribed • Prognostication shows alteration of future strife in college life • Bears upset F&M 73-55 in pre-holiday thriller • Grapplers win opener over Muhlenberg, 23-9 • Grizzlies absorb second cage loss to Pharmacy five • Bruins top Drexel 80-74 in initial league contest • Trials highlight MSGA pre-vacation meetinghttps://digitalcommons.ursinus.edu/weekly/1556/thumbnail.jp

The Ursinus Weekly, October 18, 1948

Sophs apparently foiled as freshmen prexy, Lee Trimble, is safely hidden • WAA introduces \u2752 to Ursinus sports • Dale White elected editor of Lantern as Wentzel resigns • Football, fun, light fantastic promise successful old timers\u27 day celebration • Forum to feature election discussion • Grads get degrees on Founders\u27 Day • Five men appointed to act with faculty committees • Dressner, Buchanan picked as council representatives • German club plans dinner; to make Philadelphia trip • Thespians greet applicants at first meeting of year • Former student to return in concert with soprano • Frosh show ends customs for men • NSA head requests college democracy • A happy thought for hapless frosh • Freshman reviews first two weeks • Frosh live again after customs end • Soph ruler reveals innermost thoughts • Junior looks back on freshman year • Frosh views hist.1 with heavy heart • Modern miss visits ancient Latin lands • Subs work all year but get no credit • Dickinson romps to 24-0 victory over bear; Gerry Miller features with 85 yard runback • Bears seek victory on old timers\u27 day • Coeds triumph 5-2 in season\u27s opener • Mules trip bruins in soccer opener • Church colleges hit by Lafayette prexy • Footlighters start ambitious season • Staiger writes article for organic chemistry journal • Pre-meds plan activities; members need high gradeshttps://digitalcommons.ursinus.edu/weekly/1598/thumbnail.jp

Skunk River Review September 1989, vol 1 no 1

https://openspace.dmacc.edu/skunkriver/1004/thumbnail.jp

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer : development of a prognostic model through a crowdsourced challenge with open clinical trial data

Background Improvements to prognostic models in metastatic castration-resistant prostate cancer have the potential to augment clinical trial design and guide treatment strategies. In partnership with Project Data Sphere, a not-for-profit initiative allowing data from cancer clinical trials to be shared broadly with researchers, we designed an open-data, crowdsourced, DREAM (Dialogue for Reverse Engineering Assessments and Methods) challenge to not only identify a better prognostic model for prediction of survival in patients with metastatic castration-resistant prostate cancer but also engage a community of international data scientists to study this disease. Methods Data from the comparator arms of four phase 3 clinical trials in first-line metastatic castration-resistant prostate cancer were obtained from Project Data Sphere, comprising 476 patients treated with docetaxel and prednisone from the ASCENT2 trial, 526 patients treated with docetaxel, prednisone, and placebo in the MAINSAIL trial, 598 patients treated with docetaxel, prednisone or prednisolone, and placebo in the VENICE trial, and 470 patients treated with docetaxel and placebo in the ENTHUSE 33 trial. Datasets consisting of more than 150 clinical variables were curated centrally, including demographics, laboratory values, medical history, lesion sites, and previous treatments. Data from ASCENT2, MAINSAIL, and VENICE were released publicly to be used as training data to predict the outcome of interest-namely, overall survival. Clinical data were also released for ENTHUSE 33, but data for outcome variables (overall survival and event status) were hidden from the challenge participants so that ENTHUSE 33 could be used for independent validation. Methods were evaluated using the integrated time-dependent area under the curve (iAUC). The reference model, based on eight clinical variables and a penalised Cox proportional-hazards model, was used to compare method performance. Further validation was done using data from a fifth trial-ENTHUSE M1-in which 266 patients with metastatic castration-resistant prostate cancer were treated with placebo alone. Findings 50 independent methods were developed to predict overall survival and were evaluated through the DREAM challenge. The top performer was based on an ensemble of penalised Cox regression models (ePCR), which uniquely identified predictive interaction effects with immune biomarkers and markers of hepatic and renal function. Overall, ePCR outperformed all other methods (iAUC 0.791; Bayes factor >5) and surpassed the reference model (iAUC 0.743; Bayes factor >20). Both the ePCR model and reference models stratified patients in the ENTHUSE 33 trial into high-risk and low-risk groups with significantly different overall survival (ePCR: hazard ratio 3.32, 95% CI 2.39-4.62, p Interpretation Novel prognostic factors were delineated, and the assessment of 50 methods developed by independent international teams establishes a benchmark for development of methods in the future. The results of this effort show that data-sharing, when combined with a crowdsourced challenge, is a robust and powerful framework to develop new prognostic models in advanced prostate cancer.Peer reviewe

Initial invasive or conservative strategy for stable coronary disease

BACKGROUND Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, 121.8 percentage points; 95% CI, 124.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used

Health-status outcomes with invasive or conservative care in coronary disease

BACKGROUND In the ISCHEMIA trial, an invasive strategy with angiographic assessment and revascularization did not reduce clinical events among patients with stable ischemic heart disease and moderate or severe ischemia. A secondary objective of the trial was to assess angina-related health status among these patients. METHODS We assessed angina-related symptoms, function, and quality of life with the Seattle Angina Questionnaire (SAQ) at randomization, at months 1.5, 3, and 6, and every 6 months thereafter in participants who had been randomly assigned to an invasive treatment strategy (2295 participants) or a conservative strategy (2322). Mixed-effects cumulative probability models within a Bayesian framework were used to estimate differences between the treatment groups. The primary outcome of this health-status analysis was the SAQ summary score (scores range from 0 to 100, with higher scores indicating better health status). All analyses were performed in the overall population and according to baseline angina frequency. RESULTS At baseline, 35% of patients reported having no angina in the previous month. SAQ summary scores increased in both treatment groups, with increases at 3, 12, and 36 months that were 4.1 points (95% credible interval, 3.2 to 5.0), 4.2 points (95% credible interval, 3.3 to 5.1), and 2.9 points (95% credible interval, 2.2 to 3.7) higher with the invasive strategy than with the conservative strategy. Differences were larger among participants who had more frequent angina at baseline (8.5 vs. 0.1 points at 3 months and 5.3 vs. 1.2 points at 36 months among participants with daily or weekly angina as compared with no angina). CONCLUSIONS In the overall trial population with moderate or severe ischemia, which included 35% of participants without angina at baseline, patients randomly assigned to the invasive strategy had greater improvement in angina-related health status than those assigned to the conservative strategy. The modest mean differences favoring the invasive strategy in the overall group reflected minimal differences among asymptomatic patients and larger differences among patients who had had angina at baseline