79 research outputs found
Preparing for the manned Mars journey: Microbiome dynamics in the confined Mars500 habitat during simulated Mars flight and landing
Synthesis and biological evaluation of ferrocene-based cannabinoid receptor 2 ligands
Ferrocene analogues of known fatty acid amide hydrolase inhibitors and CB2 ligands have been synthesized and characterized spectroscopically and crystallographically. The resulting bioorganometallic isoxazoles were assayed for their effects on CB1 and CB2 receptors as well as on FAAH. None had any FAAH activity but compound 3, 5-(2-(pentyloxy)phenyl)-N-ferrocenylisoxazole- 3-carboxamide, was found to be a potent CB2 ligand (Ki = 32.5 nM)
К определению поверхностного натяжения, объема и площади криволинейной поверхности по форме сидячих пузырьков или висячих капель
The multi-user facility EXPOSE-E was designed by the European Space Agency to enable astrobiology research
in space (low-Earth orbit). On 7 February 2008, EXPOSE-E was carried to the International Space Station (ISS) on
the European Technology Exposure Facility (EuTEF) platform in the cargo bay of Space Shuttle STS-122 Atlantis.
The facility was installed at the starboard cone of the Columbus module by extravehicular activity, where it
remained in space for 1.5 years. EXPOSE-E was returned to Earth with STS-128 Discovery on 12 September 2009
for subsequent sample analysis. EXPOSE-E provided accommodation in three exposure trays for a variety of
astrobiological test samples that were exposed to selected space conditions: either to space vacuum, solar
electromagnetic radiation at > 110nm and cosmic radiation (trays 1 and 3) or to simulated martian surface
conditions (tray 2). Data on UV radiation, cosmic radiation, and temperature were measured every 10 s and
downlinked by telemetry. A parallel mission ground reference (MGR) experiment was performed on ground
with a parallel set of hardware and samples under simulated space conditions. EXPOSE-E performed a
successful 1.5-year mission in space
Synthesis of bioorganometallic nanomolar-potent CB2agonists containing a ferrocene unit
A small library of ferrocene-containing amides has been synthesized using standard amide coupling chemistry with ferrocenylamine. Ferrocene analogues of known bioactive adamantylamides were shown to be effective cannabinoid receptor (CB1 and CB2) agonists, displaying, in many cases, single-digit nanomolar potency. Three final ferrocene-containing derivatives have been characterized in the solid state by X-ray crystallography and display intramolecular hydrogen bonding of the type NH---C═O. N-Methylation of the amide, confirmed by X-ray crystallography, leads to both loss of hydrogen bonding and biological activity
Discriminant Analysis and Secondary-Beam Charge Recognition
The discriminant-analysis method has been applied to optimize the exotic-beam
charge recognition in a projectile fragmentation experiment. The experiment was
carried out at the GSI using the fragment separator (FRS) to produce and select
the relativistic secondary beams, and the ALADIN setup to measure their
fragmentation products following collisions with Sn target nuclei. The beams of
neutron poor isotopes around 124La and 107Sn were selected to study the isospin
dependence of the limiting temperature of heavy nuclei by comparing with
results for stable 124Sn projectiles. A dedicated detector to measure the
projectile charge upstream of the reaction target was not used, and alternative
methods had to be developed. The presented method, based on the multivariate
discriminant analysis, allowed to increase the efficacy of charge recognition
up to about 90%, which was about 20% more than achieved with the simple scalar
methods.Comment: 6 pages, 7 eps figures, elsart, submitted to Nucl. Instr. and Meth.
Isotopic Dependence of the Nuclear Caloric Curve
The A/Z dependence of projectile fragmentation at relativistic energies has
been studied with the ALADIN forward spectrometer at SIS. A stable beam of
124Sn and radioactive beams of 124La and 107Sn at 600 MeV per nucleon have been
used in order to explore a wide range of isotopic compositions. Chemical
freeze-out temperatures are found to be nearly invariant with respect to the
A/Z of the produced spectator sources, consistent with predictions for expanded
systems. Small Coulomb effects (\Delta T \approx 0.6 MeV) appear for residue
production near the onset of multifragmentation.Comment: 11 pages, 3 figures, accepted for publ. in Phys. Rev. Let
Tracing a phase transition with fluctuations of the largest fragment size: Statistical multifragmentation models and the ALADIN S254 data
A phase transition signature associated with cumulants of the largest
fragment size distribution has been identified in statistical
multifragmentation models and examined in analysis of the ALADIN S254 data on
fragmentation of neutron-poor and neutron-rich projectiles. Characteristics of
the transition point indicated by this signature are weakly dependent on the
A/Z ratio of the fragmenting spectator source. In particular, chemical
freeze-out temperatures are estimated within the range 5.9 to 6.5 MeV. The
experimental results are well reproduced by the SMM model.Comment: 7 pages, 3 figures, Proceedings of the International Workshop on
Multifragmentation and Related Topics (IWM2009), Catania, Italy, November
2009
Gross Properties and Isotopic Phenomena in Spectator Fragmentation
A systematic study of isotopic effects in the break-up of projectile
spectators at relativistic energies has been performed with the ALADiN
spectrometer at the GSI laboratory. Searching for signals of criticality in the
fragment production we have applied the model independent universal
fluctuations theory already proposed to track criticality signals in
multifragmentation to our data. The fluctuation of the largest fragment charge
and of the asymmetry of the two and three largest fragments and their bimodal
distribution have also been analysed.Comment: 6 pages, 4 figures, IX International Conference on Nucleus-Nucleus
Collisions, Rio de Janeiro, Brazil, August 28 - September 1, 200
Neutron recognition in the LAND detector for large neutron multiplicity
The performance of the LAND neutron detector is studied. Using an
event-mixing technique based on one-neutron data obtained in the S107
experiment at the GSI laboratory, we test the efficiency of various analytic
tools used to determine the multiplicity and kinematic properties of detected
neutrons. A new algorithm developed recently for recognizing neutron showers
from spectator decays in the ALADIN experiment S254 is described in detail. Its
performance is assessed in comparison with other methods. The properties of the
observed neutron events are used to estimate the detection efficiency of LAND
in this experiment.Comment: 16 pages, 8 figure
Mass and Isospin Effects in Multifragmentation
A systematic study of isospin effects in the breakup of projectile spectators
at relativistic energies has been performed with the ALADiN spectrometer at the
GSI laboratory (Darmstadt). Four different projectiles 197Au, 124La, 124Sn and
107Sn, all with an incident energy of 600 AMeV, have been used, thus allowing a
study of various combinations of masses and N/Z ratios in the entrance channel.
The measurement of the momentum vector and of the charge of all projectile
fragments with Z>1 entering the acceptance of the ALADiN magnet has been
performed with the high efficiency and resolution achieved with the TP-MUSIC IV
detector. The Rise and Fall behavior of the mean multiplicity of IMFs as a
function of Zbound and its dependence on the isotopic composition has been
determined for the studied systems. Other observables investigated so far
include mean N/Z values of the emitted light fragments and neutron
multiplicities. Qualitative agreement has been obtained between the observed
gross properties and the predictions of the Statistical Multifragmentation
Model.Comment: 10 pages,7 figure, 18th Nuclear Physics Division Conference of the
EPS, Prague, submitted to Nucl. Phys.
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