Une relecture et des questions sur l’édifice à plan basilical trouvé en 1847 sous le parvis de Notre-Dame de Paris

Alors que des fouilles archéologiques viennent de s’achever sous le parvis de Notre-Dame de Paris, on ne peut manquer d’évoquer les interventions de ce type menées en ce lieu au cours des deux derniers siècles : deux campagnes archéologiques d’envergure, l’une conduite par Théodore Vacquer en 1847, l’autre par Michel Fleury en 1965-1970 (fig. 1), et plusieurs surveillances de travaux effectuées par la Commission du Vieux Paris entre 1907 et 1981. Fig. 1 – Commission du Vieux Paris, Inspection..

The FABSPACE 2.0 Project For Geodata-Driven Innovation

Now that the Galileo and Copernicus satellite programmes are entering their operational phase, innovation possibilities in the field of satellite data driven applications are getting wider. Thanks to these two massive investments in technology, European and worldwide companies are starting to benefit from increasing, regular and cheaper (not to say free of charge) data flows, which could lead to the development of new and innovative applications and services in an incredibly vast range of markets, including non-space markets. The exploitation of satellite data, as well as open data (from public authorities in particular) has the potential to generate a lot of innovative solutions. In this context the FabSpace 2.0 project aims at putting the Universities at the front line for the take-off of Earth Observation based applications in Europe and worldwide. This can be pursued by hosting and animating open places dedicated to space and geodata-driven innovation where young developers from the civil society, experienced developers from industry or academic and research institutes, public administrations as well as civil organizations can meet, work together and co-create new tools and business models. They can create an ecosystem fitting (and developed according to) the particularities of geodata-driven innovation, in particular for the emergence of Space data downstream services. In this innovative environment, innovation is driven by the needs of users through the involvement of civil society in the innovation process and in the definition of new challenges. Moreover the actors making innovation will be anonymous civilians (students and researchers in particular) and will thus be at the same time developers and end-users of the applications they develop. That is why the FabSpace 2.0 project is expected to improve the capacity of Universities to generate more innovations and generate positive socio-economic impacts. All partner universities are centers of excellence in research in the field of geomatics and space based information. They are not only offering a highly-qualified human capital likely to generate innovation, but also providing open access to data generated within previous research works. Thus the FabSpace 2.0 project can be a particularly relevant opportunity for research teams to make a step forward towards Science 2.0

Tree crown detection in high resolution optical and LiDAR images of tropical forest

International audienceTropical forests are complex ecosystems where the potential of remote sensing has not yet been fully realized. The increasing availability of satellite metric imagery along with canopy altimetry from airborne LiDAR open new prospects to detect individual trees. For this objective, we optimized, calibrated and applied a model based on marked point processes to detect trees in high biomass mangroves of French Guiana by considering a set of 1m pixel images including 1) panchromatic images from the IKONOS sensor 2) LiDAR-derived canopy 2D altimetry and 3) reflectance panchromatic images simulated by the DART-model. The relevance of detection is then discussed considering: (i) the agreement in space of detected crown centers locations with known true locations for the DART images and also the detection agreement for each pair of IKONOS and LiDAR images, and (ii) the comparison between the frequency distributions of the diameters of the detected crowns and of the tree trunks measured in the field. Both distributions are expected to be related due to the allometry relationships between trunk and crown

Usefulness of PKH fluorescent labelling to study leukemic cell proliferation with various cytostatic drugs or acetyl tetrapeptide – AcSDKP

BACKGROUND: PKH67 labelling was compared for classical proliferation assessment (using S phase evaluation) to analyse the cell proliferation of 29 AML patients treated or not with various drugs. Among these drugs, the effect of tetrapeptide AcSDKP or AcSDKP-NH2 on AML cells, stimulated or not by cytokines, was also evaluated in order to determine (i) if AcSDKP was able to inhibit blast cell proliferation as it inhibits haematopoietic progenitors (ii) if AcSDKP-NH2 was more stable than AcSDKP with FBS. METHODS: For PKH labeling, cells were suspended in Diluent C, and rapidly admixed with PKH67 solution at 20 μM PKH67. Staining was stopped by addition of FBS. RESULTS: A good correlation between PKH67 labelling and bromodeoxyuridine incorporation was obtained first with 6/9 patients for control cells, then for 11/17 AML patients treated with classical antileukemic drugs (among whom 4 were also treated with AcSDKP). The effect of AcSDKP was also studied on 7 patients. The discrepancy between both methods was essentially due to an accumulation of cells into different cycle phases measured by BrdUrd incorporation secondary to drug action and PKH67 labelling which measured the dynamic proliferation. This last method allows identifying resistant cells which still proliferate. AcSDKP or AcSDKP-NH2 induced a decrease of leukemic cell proliferation in 5/7 patients when cytokines were added (in order to stimulate proliferation) one day after tetrapeptide AcSDKP or AcSDKP-NH2. No effect on proliferation was noted when cytokines were added to AcSDKP-NH2. CONCLUSION: PKH67 labelling method is a powerful tool for cell proliferation assessment in patients with AML, even in cells treated by various drugs

Le sacré dans le palais franc

« Demeure des anges » (Ingelheim), « Jérusalem » (Aix-la-Chapelle), il n’est pas d’épithètes ou d’étymologies littéraires qui n’aient loué la « sacralité » du palais carolingien : le sacre royal, signe de l’élection divine, nimbait le Carolingien et son palais, parfois appelé sacrum palatium, d’une aura vénérable. Mais déjà les Mérovingiens, en qui leurs contemporains reconnaissaient Constantin (Clovis), Melchisédech (Childebert Ier) ou David (Clotaire II), avaient reçu de leur orthodoxie rel..

Palais laïques. Introduction : le haut Moyen Âge "" et (notices), "" Attigny "", "" Compiègne "", "" Ponthion "", "" Quierzy "", "" Samoussy

A. RenouxInternational audienc

Palais et terres du fisc en Neustrie, 650-850

catalogue d'exposition P. Périn et L.-C. FefferInternational audienc

« De minimis curat praetor : Hincmar, le polyptyque de Saint-Remi de Reims et les esclaves de Courtisols »

International audienc

« Un rituel politique à la cour mérovingienne : l’audience royale »

International audienc