445 research outputs found
Real world experience of response to pirfenidone in patients with idiopathic pulmonary fibrosis: a two centre retrospective study
Introduction: Pirfenidone has been shown to reduce the decline in forced vital capacity (FVC) compared to placebo in patients with idiopathic pulmonary fibrosis (IPF). Previous studies have suggested that patients with a more rapid decline in FVC during the period before starting pirfenidone experience the greatest benefit from treatment. The purpose of this retrospective observational study was to investigate the response to pirfenidone in IPF patients, comparing two groups stratified by the annual rate of decline in FVC % predicted prior to treatment. Methods: Using the rate of decline in FVC % predicted in the 12 months prior to pirfenidone, patients were stratified into slow (<5%) or rapid (≥5%) decliner groups. Comparisons in the lung function response to pirfenidone in these two groups were performed. Results: Pirfenidone resulted in no statistically significant reduction in the median annual rate of decline in FVC or FVC % predicted. In the rapid decliners, pirfenidone significantly reduced the median (IQR) annual rate of decline in FVC % predicted (-8.7 (-14.2 - -7.0) %/yr vs 2.0 (-7.1 - 6.0) %/yr; n=17; p<0.01). In the slow decliners, pirfenidone did not reduce the median (IQR) annual rate of decline in FVC % predicted (-1.3 (-3.2 - 1.3) %/yr vs -5.0 (-8.3 - -0.35) %/yr; n=17; p=0.028). Conclusions: We demonstrate the greater net effect of pirfenidone in IPF patients declining rapidly. We suggest that using an annual rate of decline in FVC of <5% and ≥5% may be useful in counselling patients with regard to pirfenidone treatment
Topological metamagnetism : thermodynamics and dynamics of the transition in spin ice under uniaxial compression
This work was carried out within the framework of a Max-Planck independent research group on strongly correlated systems. We acknowledge financial support from the Deutsche Forschungsgemeinschaft through SFB 1143 (Project No. 247310070) and Cluster of Excellence ct.qmat (EXC 2147, Project No. 390858490), EPSRC (EP/T028637/1), ShanghaiTech University, Agencia Nacional de Promoción Científica y Tecnológica through PICT 2017-2347, and Consejo Nacional de Investigaciones Científicas y Técnicas through PIP 0446.Metamagnetic transitions are analogs of a pressure-driven gas-liquid transition in water. In insulators, they are marked by a superlinear increase in the magnetization that occurs at a field strength set by the spin exchange interactions. Here we study topological metamagnets, in which the magnetization is itself a topological quantity and for which we find a single transition line for two materials with substantially different magnetic interactions: the spin ices Dy2Ti2O7 and Ho2Ti2O7. We study single crystals under magnetic field and stress applied along the [001] direction and show that this transition, of the Kasteleyn type, has a magnetization versus field curve with upward convexity and a distinctive asymmetric peak in the susceptibility. We also show that the dynamical response of Ho2Ti2O7 is sensitive to changes in the Ho3+ environment induced by compression along [001]. Uniaxial compression may open up experimental access to equilibrium properties of spin ice at lower temperatures.Publisher PDFPeer reviewe
A high stability semiconductor laser system for a Sr-based optical lattice clock
We describe a frequency stabilized diode laser at 698 nm used for high
resolution spectroscopy of the 1S0-3P0 strontium clock transition. For the
laser stabilization we use state-of-the-art symmetrically suspended optical
cavities optimized for very low thermal noise at room temperature. Two-stage
frequency stabilization to high finesse optical cavities results in measured
laser frequency noise about a factor of three above the cavity thermal noise
between 2 Hz and 11 Hz. With this system, we demonstrate high resolution remote
spectroscopy on the 88Sr clock transition by transferring the laser output over
a phase-noise-compensated 200 m-long fiber link between two separated
laboratories. Our dedicated fiber link ensures a transfer of the optical
carrier with frequency stability of 7 \cdot 10^{-18} after 100 s integration
time, which could enable the observation of the strontium clock transition with
an atomic Q of 10^{14}. Furthermore, with an eye towards the development of
transportable optical clocks, we investigate how the complete laser system
(laser+optics+cavity) can be influenced by environmental disturbances in terms
of both short- and long-term frequency stability.Comment: 9 pages, 9 figures, submitted to Appl. Phys.
High Precision Mass Measurements in and Families Revisited
High precision mass measurements in and families performed
in 1980-1984 at the VEPP-4 collider with OLYA and MD-1 detectors are revisited.
The corrections for the new value of the electron mass are presented. The
effect of the updated radiative corrections has been calculated for the
and mass measurements.Comment: 5 pages, 1 table, submitted to Phys. Lett.
Evidence for exercise-based interventions across 45 different long-term conditions: An overview of systematic reviews
Background
Almost half of the global population face significant challenges from long-term conditions (LTCs) resulting in substantive health and socioeconomic burden. Exercise is a potentially key intervention in effective LTC management.
Methods
In this overview of systematic reviews (SRs), we searched six electronic databases from January 2000 to October 2023 for SRs assessing health outcomes (mortality, hospitalisation, exercise capacity, disability, frailty, health-related quality of life (HRQoL), and physical activity) related to exercise-based interventions in adults (aged >18 years) diagnosed with one of 45 LTCs. Methodological quality was assessed using AMSTAR-2. International Prospective Resister of Systematic Reviews (PROSPERO) ID: CRD42022319214.
Findings
Forty-two SRs plus three supplementary RCTs were included, providing 990 RCTs in 936,825 people across 39 LTCs. No evidence was identified for six LTCs. Predominant outcome domains were HRQoL (82% of SRs/RCTs) and exercise capacity (66%); whereas disability, mortality, physical activity, and hospitalisation were less frequently reported (≤25%). Evidence supporting exercise-based interventions was identified in 25 LTCs, was unclear for 13 LTCs, and for one LTC suggested no effect. No SRs considered multimorbidity in the delivery of exercise. Methodological quality varied: critically-low (33%), low (26%), moderate (26%), and high (12%).
Interpretation
Exercise-based interventions improve HRQoL and exercise capacity across numerous LTCs. Key evidence gaps included limited mortality and hospitalisation data and consideration of multimorbidity impact on exercise-based interventions.
Funding
This study was funded by the National Institute for Health and Care Research (NIHR; Personalised Exercise-Rehabilitation FOR people with Multiple long-term conditions (multimorbidity)—NIHR202020)
New precision measurement of the - and -meson masses
A new high precision measurement of the - and -meson masses
has been performed at the VEPP-4M collider using the KEDR detector. The
resonant depolarization method has been employed for the absolute calibration
of the beam energy. The following mass values have been obtained:
MeV,
MeV.
The relative measurement accuracy has reached for and
for , approximately 3 times better than in the previous
precise experiments.Comment: 12 pages, 4 tables, 10 figure
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