The Impact of AIDS Treatment on Savings and Human Capital Investment in Malawi

Antiretroviral therapy (ART), a treatment for AIDS, is rapidly increasing life expectancy throughout Africa. A longer life expectancy increases the value of human capital investment, though the effect on savings is theoretically ambiguous. This paper uses spatial and temporal variation in ART availability to evaluate the impact of ART provision on savings and investment. We find that ART availability significantly increases savings, expenditures on children, and children\u27s schooling, particularly among HIV-negative individuals. These results are not driven by the direct health effects of treatment or reductions in caretaking responsibilities, but rather by improving perceptions of self-reported mortality risk

Men. Roots and Consequences of Masculinity Norms

Recent research has uncovered the historical roots of gender norms about women and the persistent effect of such norms on economic development. We find similar long-term effects of masculinity norms: beliefs about the proper conduct of men. We exploit a natural historical experiment in which convict transportation in the 18th and 19th century created a variegated spatial pattern of sex ratios across Australia. We show that in areas that were heavily male-biased in the past (though not the present) more Australians recently voted against same-sex marriage, an institution at odds with traditional masculinity norms. Survey data show that this voting pattern is mostly driven by men. Further evidence indicates that these historically male-biased areas also remain characterized by more violence, excessive alcohol consumption, and occupational gender segregation. We interpret these behaviors as manifestations of masculinity norms that emerged due to intense local male-male competition and that persisted over time

The Indirect Impact of Antiretroviral Therapy

In response to AIDS mortality in Sub-Saharan Africa, international donors have collaborated with many national governments to provide free antiretroviral therapy (ART) to people with HIV. We explore the impact of this decline in objective mortality risk on subjective perceptions of mortality risk, as well as mental health, and agricultural labor supply and output. Through a difference-indifference identification strategy, we find that ART availability substantially reduces subjective mortality risk and improves mental health in rural Malawi, including among HIV-negative respondents. People allocate significantly more time to subsistence maize cultivation and increase maize output. These results show a novel link between mortality conditions and economic development through the channel of mental health. Findings for the HIV-negative subpopulation also demonstrate that the impact of the AIDS epidemic and ART are broader than previously understood

The risk and time preferences of young truants and their parents

We use an incentivized experiment to measure the risk and time preferences of truant adolescents and their parents. We find that adolescent preferences do not predict school attendance and that a unique police-school partnership program targeting school absences was most effective in reducing the truancy of adolescents with relatively risk-averse parents

Maternal Depression, Women's Empowerment, and Parental Investment: Evidence from a Randomized Control Trial

We evaluate the medium-term impacts of treating maternal depression on women's mental health, financial empowerment, and parenting decisions. We leverage variation induced by a cluster-randomized control trial that provided psychotherapy to 903 pre-natally depressed mothers in rural Pakistan. It was one of the world's largest psychotherapy interventions, and it dramatically reduced postpartum depression. Seven years after psychotherapy concluded, we returned to the study site to find that impacts on women's mental health had persisted, with a 17% reduction in depression rates. The intervention also improved women's financial empowerment and increased both time- and money-intensive parental investments by between 0.2 and 0.3 standard deviations

Trajectories of early childhood skill development and maternal mental health

We investigate the impacts of a perinatal psychosocial intervention on trajectories of maternal mental health and child skills, from birth to age 3. We find improved maternal mental health and functioning (0.17 – 0.29 SD), modest but imprecisely estimated improvements in parental investments (0.07 to 0.11 SD), and transitory improvements in child socioemotional development (0.06 to 0.39 SD). We also find negligible influence of the intervention on physical health and cognitive development. Estimates of a skill production function reveal that the intervention is associated with reduced productivity of maternal mental health and narrowed “depression gaps” in mother and child outcomes

Effects of a maternal psychosocial intervention on hair derived biomarkers of HPA axis function in mothers and children in rural Pakistan

Objective Disruptions in the hypothalamic-pituitary-adrenal (HPA) axis are thought to be key neuroendocrine mechanisms involved in psychopathology and may have intergenerational impacts. Hair-derived HPA hormones offer a measure of long-term HPA axis activity that may be useful in assessing maternal and infant health. Building on a community-based randomized control trial of a perinatal depression intervention in Pakistan, we examine intervention effects on HPA axis activity in a subsample of mothers and infants. Methods HPA axis activity was assessed using hair-derived cortisol, cortisone, and dehydroepiandosterone (DHEA). Hair samples were collected from mother-child dyads at one year postpartum from prenatally depressed women randomized to a cognitive-behavioral intervention (n ​= ​35 dyads) or to enhanced usual care (n ​= ​37 dyads), and from a comparison sample of women who screened negative for depression in pregnancy (n ​= ​35 dyads). Results The intervention group had 38 percent (p=0.01) lower maternal cortisol levels and 45 percent (p ​< ​0.01) lower maternal cortisone compared to the EUC group. Maternal DHEA levels were higher among women in the intervention group compared to the EUC group by 29 percent (p ​= ​0.02). Intergenerational intervention effects show higher DHEA levels in infants by 43% (p ​= ​0.03). Infant cortisol and cortisone did not differ across groups. Conclusions Results suggest that the perinatal depression intervention has effects on HPA axis activity in both mothers and children, providing evidence that treating maternal depression may impact physiological stress system functioning intergenerationally. In addition, utilizing hair-derived biomarkers of HPA-axis activity is a potentially useful clinical indicator of intervention impacts on the neuroendocrine system

Effectiveness of a peer-delivered, psychosocial intervention on maternal depression and child development at 3 years postnatal: a cluster randomised trial in Pakistan

Maternal depression has a recurring course that can influence offspring outcomes. Evidence on how to treat maternal depression to improve longer-term maternal outcomes and reduce intergenerational transmission of psychopathology is scarce, particularly for task-shifted, low-intensity, and scalable psychosocial interventions. We evaluated the effects of a peer-delivered, psychosocial intervention on maternal depression and child development at 3 years postnatal

The contribution of grandmother involvement to child growth and development: an observational study in rural Pakistan

INTRODUCTION: Early childhood interventions primarily focus on the mother-child relationship, but grandmothers are often critical in childcare in low-resource settings. Prior research is mixed on how grandmother involvement influences child outcomes and there is a paucity of research on grandmother caregiving in low-income and middle-income countries. We examined the role of grandmother involvement on child growth and development in the first 2 years of life cross sectionally and longitudinally in rural Pakistan. METHODS: We used data from the Bachpan Cohort, a longitudinal birth cohort in rural Pakistan. Maternally reported grandmother involvement in daily instrumental and non-instrumental caregiving was collected at 3 and 12 months. A summed score was created and categorised into non-involved, low and high. Outcomes included 12-month and 24-month child growth, 12-month Bayley Scales of Infant and Toddler Development and 24-month Ages and Stages Questionnaire-Socioemotional. We used multivariable generalised linear models to estimate mean differences (MD) at 12 months (n=727) and 24 months (n=712). Inverse probability weighting was used to account for missingness and sampling. RESULTS: In our sample, 68% of children lived with a grandmother, and most grandmothers were involved in caregiving. Greater 3-month grandmother involvement was positively associated with 12-month weight z-scores; however, greater involvement was associated with lower 24-month weight z-scores. High 12-month grandmother involvement was associated with improved 12-month cognitive (MD=0.38, 95% CI -0.01 to 0.76), fine motor skills (MD=0.45, 95% CI 0.08 to 0.83) and 24-month socioemotional development (MD=-17.83, 95% CI -31.47 to -4.19). No meaningful associations were found for length z-scores or language development. CONCLUSION: In rural Pakistan, grandmothers provide caregiving that influences early child development. Our findings highlight the complex relationship between grandmother involvement and child weight, and suggest that grandmothers may positively promote early child cognitive, fine motor and socioemotional development. Understanding how grandmother involvement affects child outcomes in early life is necessary to inform caregiving interventions

Positioning Europe for the EPITRANSCRIPTOMICS challenge

The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.SCOPUS: no.jinfo:eu-repo/semantics/publishe