Improved impact performance of marine sandwich panels using through-thickness reinforcement: Experimental results

This paper presents results from a test developed to simulate the water impact (slamming) loading of sandwich boat structures. A weighted elastomer ball is dropped from increasing heights onto rigidly supported panels until damage is detected. Results from this test indicate that honeycomb core sandwich panels, the most widely used material for racing yacht hulls, start to damage due to core crushing at impact energies around 550 J. Sandwich panels of the same areal weight and with the same carbon/epoxy facings but using a novel foam core reinforced in the thickness direction with pultruded carbon fibre pins, do not show signs of damage until above 1200 J impact energy. This suggests that these will offer significantly improved resistance to wave impact. Quasi-static test results cannot be used to predict impact resistance here as the crush strength of the pinned foam is more sensitive to loading rate than that of the honeycomb core

Modeling Stable Matching Problems with Answer Set Programming

The Stable Marriage Problem (SMP) is a well-known matching problem first introduced and solved by Gale and Shapley (1962). Several variants and extensions to this problem have since been investigated to cover a wider set of applications. Each time a new variant is considered, however, a new algorithm needs to be developed and implemented. As an alternative, in this paper we propose an encoding of the SMP using Answer Set Programming (ASP). Our encoding can easily be extended and adapted to the needs of specific applications. As an illustration we show how stable matchings can be found when individuals may designate unacceptable partners and ties between preferences are allowed. Subsequently, we show how our ASP based encoding naturally allows us to select specific stable matchings which are optimal according to a given criterion. Each time, we can rely on generic and efficient off-the-shelf answer set solvers to find (optimal) stable matchings.Comment: 26 page

Magnetic order in the two-dimensional metal-organic framework manganese pyrazinecarboxylate with Mn-Mn dimers

The magnetic properties of [Mn(pyrazinecarboxylate)2]n (Mn-pyrazine), empirical formula C10H6MnN4O4, are investigated through susceptibility, heat capacity and neutron scattering measurements. The structure of Mn-pyrazine consists of Mn-Mn dimers linked on a distorted 2D hexagonal structure. The weak out of plane interactions create a quasi-2D magnetic material within the larger three dimensional metal organic framework (MOF) structure. We show that this material undergoes a two stage magnetic transition, related to the low dimensionality of the Mn lattice. First at 5 K, which is assigned to the initial development of short range order in the 2D layers. This is followed by long range order at 3.3 K. Applied field measurements reveal the potential to induce magnetic transitions in moderately small fields of 2 T. Neutron powder diffraction enabled the determination of a unique magnetic space group P21'/c (#14.77) at 1.5 K. This magnetic structure consists of antiferromagnetically coupled Mn-Mn dimers with spins principally along the out of plane a-axis

Medical Waste Storage Practice in Health Care Institutions of Pokhara Sub-metropolitan City

Introduction: Medical wastes include all the waste generated by health care establishments, research facilities, and laboratories. Medi­cal waste is any waste that is generated in the diagnosis, treatment or immunization of human beings or animals, in research pertaining there to or in the productions or testing of biological culture. Methods: The fourteen numbers of health care institutions (HCIs) having inpatient facilities, were sampled for the study. After taking ob­servation, the collected information was entered into a computer. Basi­cally, the percentages, projection analysis, simple average, and scenario analysis were used as an analysis tools. Results: Out of the HCIs surveyed, only 21.43% of them had a separate room assigned for primary storage of all sorts of waste and remaining 78.57% of them had open storage facilities for un-segregated mass of waste nearby the incineration area or open burning area. Conclusion: There was lack of appropriate information on waste stor­age practices, and unaware of designing central storage system in HCIs. In most of the HCIs, a separate storage room was not assigned for stor­age of all sorts of waste. Journal of Gandaki Medical College Vol. 10, No. 1, 2017, page: 31-3

Translation and validation of the Nepalese version of Derriford appearance scale (DAS-59)

Objectives: To establish a valid and reliable translated version of Derriford Appearance Scale (DAS 59) for Nepali population.Methods: A standard translation-back-translation procedure was used followed by evaluation of semantic, conceptual and society equivalence by the committee and changes were made according to recommendations. This corrected version was pretested and a final version was developed. A validation study was performed using the final version on 424 patients including 212 patients with clinical appearance problems and similar number of young adults who had no concern for facial appearance. Reliability was assessed by cronbach’s alpha value and test-retest correlation coefficient. Discriminate and convergent validity were assessed by comparison between clinical and normal population and correlation with Beck’s Anxiety Inventory(BAI), Beck’s Depression Inventory(BDI)and General Health questionnaire (GHQ) Results: The results indicated excellent internal consistency (Cronbach’s alpha = 0.98) and good test –retest reliability (0.91 for clinical population, 0.86 for normal population). The Discriminate validity was good with statistically significant differences between clinical and normal population .The convergent validity was confirmed by good correlation with other related psychometric tools.Conclusion: A valid and reliable Nepali DAS59 version was developed which can be used for research and clinical assessment of patients with appearance problems and concerns

Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12.

Although chemokines are well established to function in immunity and endothelial cell activation and proliferation, a rapidly growing literature suggests that CXC Chemokine receptors CXCR3, CXCR4 and CXCR7 are critical in the development and progression of solid tumors. The effect of these chemokine receptors in tumorigenesis is mediated via interactions with shared ligands I-TAC (CXCL11) and SDF-1 (CXCL12). Over the last decade, CXCR4 has been extensively reported to be overexpressed in most human solid tumors and has earned considerable attention toward elucidating its role in cancer metastasis. To enrich the existing armamentarium of anti-cancerous agents, many inhibitors of CXCL12-CXCR4 axis have emerged as additional or alternative agents for neo-adjuvant treatments and even many of them are in preclinical and clinical stages of their development. However, the discovery of CXCR7 as another receptor for CXCL12 with rather high binding affinity and recent reports about its involvement in cancer progression, has questioned the potential of "selective blockade" of CXCR4 as cancer chemotherapeutics. Interestingly, CXCR7 can also bind another chemokine CXCL11, which is an established ligand for CXCR3. Recent reports have documented that CXCR3 and their ligands are overexpressed in different solid tumors and regulate tumor growth and metastasis. Therefore, it is important to consider the interactions and crosstalk between these three chemokine receptors and their ligand mediated signaling cascades for the development of effective anti-cancer therapies. Emerging evidence also indicates that these receptors are differentially expressed in tumor endothelial cells as well as in cancer stem cells, suggesting their direct role in regulating tumor angiogenesis and metastasis. In this review, we will focus on the signals mediated by this receptor trio via their shared ligands and their role in tumor growth and progression

From Rags to Riches: Assessing poverty and vulnerability in urban Nepal

Urbanisation brings with it rapid socio-economic change with volatile livelihoods and unstable ownership of assets. Yet, current measures of wealth are based predominantly on static livelihoods found in rural areas. We sought to assess the extent to which seven common measures of wealth appropriately capture vulnerability to poverty in urban areas. We then sought to develop a measure that captures the characteristics of one urban area in Nepal. We collected and analysed data from 1,180 households collected during a survey conducted between November 2017 and January 2018 and designed to be representative of the Kathmandu valley. A separate survey of a sub set of households was conducted using participatory qualitative methods in slum and non-slum neighbourhoods. A series of currently used indices of deprivation were calculated from questionnaire data. We used bivariate statistical methods to examine the association between each index and identify characteristics of poor and non-poor. Qualitative data was used to identify characteristics of poverty from the perspective of urban poor communities which were used to construct an Urban Poverty Index that combined asset and consumption focused context specific measures of poverty that could be proxied by easily measured indicators as assessed through multivariate modelling. We found a strong but not perfect association between each measure of poverty. There was disagreement when comparing the consumption and deprivation index on the classification of 19% of the sample. Choice of short-term monetary and longer-term capital approaches accounted for much of the difference. Those who reported migrating due to economic necessity were most likely to be categorised as poor. A combined index was developed to capture these dimension of poverty and understand urban vulnerability. A second version of the index was constructed that can be computed using a smaller range of variables to identify those in poverty. Current measures may hide important aspects of urban poverty. Those who migrate out of economic necessity are particularly vulnerable. A composite index of socioeconomic status helps to capture the complex nature of economic vulnerability

Ionic Transport Properties in Nanocrystalline Ce0.8A0.2O2-δ (with A = Eu, Gd, Dy, and Ho) Materials

The ionic transport properties of nanocrystalline 20 mol% Eu, Gd, Dy, and Ho doped cerias, with average grain size of around 14 nm were studied by correlating electrical, dielectric properties, and various dynamic parameters. Gd-doped nanocrystalline ceria shows higher value of conductivity (i.e., 1.8 × 10−4 S cm−1 at 550°C) and a lower value of association energy of oxygen vacancies with trivalent dopants Gd3+ (i.e., 0.1 eV), compared to others. Mainly the lattice parameters and dielectric constants (ε∞) are found to control the association energy of oxygen vacancies in these nanomaterials, which in turn resulted in the presence of grain and grain boundary conductivity in Gd- and Eu-doped cerias and only significant grain interior conductivity in Dy- and Ho-doped cerias