Continuous Statistical Models: With or Without Truncation Parameters?

Lifetime data are usually assumed to stem from a continuous distribution supported on [0, b) for some b ≤ ∞. The continuity assumption implies that the support of the distribution does not have atom points, particularly not at 0. Accordingly, it seems reasonable that with an accurate measurement tool all data observations will be positive. This suggests that the true support may be truncated from the left. In this work we investigate the effects of adding a left truncation parameter to a continuous lifetime data statistical model. We consider two main settings: right truncation parametric models with possible left truncation, and exponential family models with possible left truncation. We analyze the performance of some optimal estimators constructed under the assumption of no left truncation when left truncation is present, and vice versa. We investigate both asymptotic and finite-sample behavior of the estimators. We show that when left truncation is not assumed but is, in fact present, the estimators have a constant bias term, and therefore will result in inaccurate and inefficient estimation. We also show that assuming left truncation where actually there is none, typically does not result in substantial inefficiency, and some estimators in this case are asymptotically unbiased and efficient

The Medical Necessity for Medicinal Cannabis: Prospective, Observational Study Evaluating the Treatment in Cancer Patients on Supportive or Palliative Care

Background. Cancer patients using cannabis report better influence from the plant extract than from synthetic products. However, almost all the research conducted to date has been performed with synthetic products. We followed patients with a medicinal cannabis license to evaluate the advantages and side effects of using cannabis by cancer patients. Methods. The study included two interviews based on questionnaires regarding symptoms and side effects, the first held on the day the license was issued and the second 6–8 weeks later. Cancer symptoms and cannabis side effects were documented on scales from 0 to 4 following the CTCAE. The distress thermometer was used also. Results. Of the 211 patients who had a first interview, only 131 had the second interview, 25 of whom stopped treatment after less than a week. All cancer or anticancer treatment-related symptoms showed significant improvement (P<0.001). No significant side effects except for memory lessening in patients with prolonged cannabis use (P=0.002) were noted. Conclusion. The positive effects of cannabis on various cancer-related symptoms are tempered by reliance on self-reporting for many of the variables. Although studies with a control group are missing, the improvement in symptoms should push the use of cannabis in palliative treatment of oncology patients

Proof of principle of a high-spatial-resolution, resonant-response gamma-ray detector for Gamma Resonance Absorption in 14N

The development of a mm-spatial-resolution, resonant-response detector based on a micrometric glass capillary array filled with liquid scintillator is described. This detector was developed for Gamma Resonance Absorption (GRA) in 14N. GRA is an automatic-decision radiographic screening technique that combines high radiation penetration (the probe is a 9.17 MeV gamma ray) with very good sensitivity and specificity to nitrogenous explosives. Detailed simulation of the detector response to electrons and protons generated by the 9.17 MeV gamma-rays was followed by a proof-of-principle experiment, using a mixed gamma-ray and neutron source. Towards this, a prototype capillary detector was assembled, including the associated filling and readout systems. Simulations and experimental results indeed show that proton tracks are distinguishable from electron tracks at relevant energies, on the basis of a criterion that combines track length and light intensity per unit length.Comment: 18 pages, 16 figure

Emergence of hyperons in failed supernovae: trigger of the black hole formation

We investigate the emergence of strange baryons in the dynamical collapse of a non-rotating massive star to a black hole by the neutrino-radiation hydrodynamical simulations in general relativity. By following the dynamical formation and collapse of nascent proto-neutron star from the gravitational collapse of a 40Msun star adopting a new hyperonic EOS table, we show that the hyperons do not appear at the core bounce but populate quickly at ~0.5-0.7 s after the bounce to trigger the re-collapse to a black hole. They start to show up off center owing to high temperatures and later prevail at center when the central density becomes high enough. The neutrino emission from the accreting proto-neutron star with the hyperonic EOS stops much earlier than the corresponding case with a nucleonic EOS while the average energies and luminosities are quite similar between them. These features of neutrino signal are a potential probe of the emergence of new degrees of freedom inside the black hole forming collapse.Comment: 11 pages, 3 figures, accepted for publication in ApJ

Human Dental Microwear From Ohalo II (22,500–23,500 cal BP), Southern Levant

Dietary hardness and abrasiveness are inferred from human dental microwear at Ohalo II, a late Upper Palaeolithic site (22,500–23,500 cal BP) in the southern Levant. Casts of molar grinding facets from two human skeletons were examined with a scanning electron microscope. The size and frequency of microwear was measured, counted, and compared to four prehistoric human groups from successive chronological periods in the same region: pre-pottery Neolithic A, Chalcolithic (this study); Natufian, pre-pottery Neolithic B (Mahoney: Am J Phys Anthropol 130 (2006) 308–319). The Ohalo molars had a high frequency of long narrow scratches, and a few small pits, suggesting a tough abrasive diet that required more shearing rather than compressive force while chewing. These results imply that the diet of the two late Upper Palaeolithic hunter-gatherers did not focus on very hard foods. Aquatic foods with adherent contaminants, as well as grit from plant grinding tools seemed likely causal agents. The size of the pits and scratches on the Ohalo molars were most similar to microwear from the pre-pot- tery Neolithic A period, though they also compared well to the Chalcolithic period. These results contrasted with the larger pits and scratches from the Natufian hunter-gath- erers and pre-pottery Neolithic B farmers, implying that there is no simple increase or decrease in dietary hard- ness and abrasiveness across the late Upper Palaeolithic to Chalcolithic development in the Southern Levant

Data-Collection for the Sloan Digital Sky Survey: a Network-Flow Heuristic

The goal of the Sloan Digital Sky Survey is ``to map in detail one-quarter of the entire sky, determining the positions and absolute brightnesses of more than 100 million celestial objects''. The survey will be performed by taking ``snapshots'' through a large telescope. Each snapshot can capture up to 600 objects from a small circle of the sky. This paper describes the design and implementation of the algorithm that is being used to determine the snapshots so as to minimize their number. The problem is NP-hard in general; the algorithm described is a heuristic, based on Lagriangian-relaxation and min-cost network flow. It gets within 5-15% of a naive lower bound, whereas using a ``uniform'' cover only gets within 25-35%.Comment: proceedings version appeared in ACM-SIAM Symposium on Discrete Algorithms (1998

Structural Characterization of Charcoal Exposed to High and Low pH: Implications for 14C Sample Preparation and Charcoal Preservation

Chemical and structural similarities between poorly preserved charcoal and its contaminants, as well as low radiocarbon concentrations in old samples, complicate 14C age determinations. Here, we characterize 4 fossil charcoal samples from the late Middle Paleolithic and early Upper Paleolithic strata of Kebara Cave, Israel, with respect to the structural and chemical changes that occur when they are subjected to the acid-base-acid (ABA) treatment. Differential thermal analysis and TEM show that acid treatment disrupts the structure, whereas alkali treatment results in the reformation of molecular aggregates. The major changes are ascribed to the formation of salt bridges at high pH and the disruption of the graphite-like crystallites at low pH. Weight losses during the treatments are consistently greater for older samples, implying that they are less well preserved. Based on the changes observed in vitro due to pH fluctuations, various methods for removing contamination, as well as a mechanism for preferential preservation of charcoal in nature, are proposed.Anthropolog

Detectors for the Gamma-Ray Resonant Absorption (GRA) Method of Explosives Detection in Cargo: A Comparative Study

Gamma-Ray Resonant Absorption (GRA) is an automatic-decision radiographic screening technique that combines high radiation penetration with very good sensitivity and specificity to nitrogenous explosives. The method is particularly well-suited to inspection of large, massive objects (since the incident gamma-ray probe is at 9.17 MeV) such as aviation and marine containers, heavy vehicles and railroad cars. Two kinds of gamma-ray detectors have been employed to date in GRA systems: 1) Resonant-response nitrogen-rich liquid scintillators and 2) BGO detectors. This paper analyses and compares the response of these detector-types to the resonant radiation, in terms of single-pixel figures of merit. The latter are sensitive not only to detector response, but also to accelerator-beam quality, via the properties of the nuclear reaction that produces the resonant gamma-rays. Generally, resonant detectors give rise to much higher nitrogen-contrast sensitivity in the radiographic image than their non-resonant detector counterparts and furthermore, do not require proton beams of high energy-resolution. By comparison, the non-resonant detectors have higher gamma-detection efficiency, but their contrast sensitivity is very sensitive to the quality of the accelerator beam. Implications of these detector/accelerator characteristics for eventual GRA field systems are discussed.Comment: 11 page