Aspect ratio dependence of heat transport by turbulent Rayleigh-B\'{e}nard convection in rectangular cells

We report high-precision measurements of the Nusselt number $Nu$ as a function of the Rayleigh number $Ra$ in water-filled rectangular Rayleigh-B\'{e}nard convection cells. The horizontal length $L$ and width $W$ of the cells are 50.0 cm and 15.0 cm, respectively, and the heights $H=49.9$, 25.0, 12.5, 6.9, 3.5, and 2.4 cm, corresponding to the aspect ratios $(\Gamma_x\equiv L/H,\Gamma_y\equiv W/H)=(1,0.3)$, $(2,0.6)$, $(4,1.2)$, $(7.3,2.2)$, $(14.3,4.3)$, and $(20.8,6.3)$. The measurements were carried out over the Rayleigh number range $6\times10^5\lesssim Ra\lesssim10^{11}$ and the Prandtl number range $5.2\lesssim Pr\lesssim7$. Our results show that for rectangular geometry turbulent heat transport is independent of the cells' aspect ratios and hence is insensitive to the nature and structures of the large-scale mean flows of the system. This is slightly different from the observations in cylindrical cells where $Nu$ is found to be in general a decreasing function of $\Gamma$, at least for $\Gamma=1$ and larger. Such a difference is probably a manifestation of the finite plate conductivity effect. Corrections for the influence of the finite conductivity of the top and bottom plates are made to obtain the estimates of $Nu_{\infty}$ for plates with perfect conductivity. The local scaling exponents $\beta_l$ of $Nu_{\infty}\sim Ra^{\beta_l}$ are calculated and found to increase from 0.243 at $Ra\simeq9\times10^5$ to 0.327 at $Ra\simeq4\times10^{10}$.Comment: 15 pages, 7 figures, Accepted by Journal of Fluid Mechanic

Experiment and Finite-element-method Analysis of Steel Frame Joints Transferring Forces Outside Box Columns

Based on experimental results of two steel frame joints transferring forces outside box columns and two simple joints without inner diaphragms, by widely used finite-element-method program ANSYS, these two types of steel frame joints and traditional joints with inner diaphragms were modeled in this paper. By comparing their load-displacement curves, distributions of Von-Mises stresses and stresses path, effectiveness of the adding force-transforming plates was proofed. The carrying capacities of joints transferring forces outside box columns by adding force-transforming plates are much greater than those of joints without inner diaphragms, and are close to those of traditional joints. The adding force-transforming plates can effectively reduce the stresses of panel zone and change the way of transmitting stresses, and the brittle fracture near the butt weld with high stresses can be avoided

Extended Stochastic Gradient Identification Method for Hammerstein Model Based on Approximate Least Absolute Deviation

In order to identify the parameters of nonlinear Hammerstein model which are contaminated by colored noise and peak noise, the least absolute deviation (LAD) is selected as the objective function to solve the problem of large residual square when the identification data is disturbed by the impulse noise which obeys symmetrical alpha stable (SαS) distribution. However, LAD cannot meet the need of differentiability required by most algorithms. To improve robustness and to solve the nondifferentiable problem, an approximate least absolute deviation (ALAD) objective function is established by introducing a deterministic function to replace absolute value under certain situations. The proposed method is derived from ALAD criterion and extended stochastic gradient method. Due to the differentiability of the objective function, we can get a recursive identification algorithm which is simple and easy to calculate compared with LAD. The convergence of the proposed identification method is also proved by Lyapunov stability theory, and the simulation experiments show that the proposed method has higher accuracy and stronger robustness than the least square (LS) method in the identification of Hammerstein model with colored noise and impulse noise. The impact of impulse noise can be restrained effectively

Serum ApoB levels in depressive patients: associated with cognitive deficits

Cognitive deficits have been regarded as one of the most significant clinical symptoms of depressive disorder. Accumulating evidence has shown that apolipoprotein B (ApoB) levels, which are responsible for inducing neurodegeneration, may be involved in cognitive deficits. This study examines cognitive deficits, and the correlation of serum ApoB levels with cognitive deficits of depressive disorder. 90 depressive patients and 90 healthy controls with matched age and gender were recruited. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum ApoB levels in depressive patients were measured by immunoturbidimetric method. Our results showed that depressive patients had lower scores of cognition including RBANS total score and subscales of language and delayed memory (all, p \u3c 0.001) than healthy controls after controlling for the variables. The differences in cognitive functions also passed Bonferroni corrections. Serum ApoB levels were negatively correlated with delayed memory score in depressive patients (r = −0.30, p = 0.01). Furthermore, stepwise multivariate regression analysis indicated that serum ApoB levels independently contributed to delayed memory in depressive patients (t = −2.68, p = 0.01). Our findings support that serum ApoB levels may be involved in delayed memory decline in depressive patients. Depressive patients also experience greater cognitive deficits, especially in delayed memory and language than healthy controls

N-Acetylcysteine Suppresses LPS-Induced Pathological Angiogenesis

Background/Aims: Angiogenesis is a key feature during embryo development but is also part of the pathogenesis of cancer in adult life. Angiogenesis might be modulated by inflammation. Methods: We established an angiogenesis model in chick chorioallantoic membrane (CAM) induced by the exposure of lipopolysaccharide (LPS), and analyzed the effects of the antioxidant N-acetylcysteine (NAC) on angiogenesis in this model as well as on the expression of key genes known to involved in the regulation of angiogenesis. Results: Treatment with NAC was able to normalize LPS induced angiogenesis and restore the LPS-induced damage of vascular epithelium in chick CAM. Using quantitative PCR, we showed that NAC administration normalized the LPS induced expression of Keap1-Nrf2 signaling and oxidative stress key enzyme gene expressions (SOD, GPx and YAP1). Conclusion: We established a LPS-induced angiogenesis model in chick CAM. NAC administration could effectively inhibit LPS-induced angiogenesis and restore the integrity of endothelium on chick CAM. LPS exposure caused an increased expression of genes involved in oxidative stress in chick CAM. NAC administration could abolish this effect

The α1‐adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway

Elevated body iron stores are associated with hypertension progression, while hypertension is associated with elevated plasma catecholamine levels in patients. However, there is a gap in our understanding of the connection between catecholamines and iron regulation. Hepcidin is a key iron‐regulatory hormone, which maintains body iron balance. In the present study, we investigated the effects of adrenaline (AD) and norepinephrine (NE) on hepatic hepcidin regulation. Mice were treated with AD, NE, phenylephrine (PE, α1‐adrenergic receptor agonist), prazosin (PZ, α1‐adrenergic receptor antagonist), and/or propranolol (Pro, β‐adrenergic receptor antagonist). The levels of hepcidin, as well as signal transducer and activator of transcription 3 (STAT3), ferroportin 1 (FPN1), and ferritin‐light (Ft‐L) protein in the liver or spleen, were assessed. Six hours after AD, NE, or PE treatment, hepatic hepcidin mRNA levels increased. Pretreatment with PZ, but not Pro, abolished the effects of AD or NE on STAT3 phosphorylation and hepatic hepcidin expression. When mice were treated with AD or NE continuously for 7 days, an increase in hepatic hepcidin mRNA levels and serum hepcidin concentration was also observed. Meanwhile, the expected downstream effects of elevated hepcidin, namely decreased FPN1 expression and increased Ft‐L protein and non‐heme iron concentrations in the spleen, were observed after the continuous AD or NE treatments. Taken together, we found that AD or NE increase hepatic hepcidin expression via the α1‐adrenergic receptor and STAT3 pathways in mice. The elevated hepatic hepcidin decreased FPN1 levels in the spleen, likely causing the increased iron accumulation in the spleen

Physics perspectives of heavy-ion collisions at very high energy

Heavy-ion collisions at very high colliding energies are expected to produce a quark-gluon plasma (QGP) at the highest temperature obtainable in a laboratory setting. Experimental studies of these reactions can provide an unprecedented range of information on properties of the QGP at high temperatures. We report theoretical investigations of the physics perspectives of heavy-ion collisions at a future high-energy collider. These include initial parton production, collective expansion of the dense medium, jet quenching, heavy-quark transport, dissociation and regeneration of quarkonia, photon and dilepton production. We illustrate the potential of future experimental studies of the initial particle production and formation of QGP at the highest temperature to provide constraints on properties of strongly interaction matter.Comment: 35 pages in Latex, 29 figure

A Macromolecular Approach to Eradicate Multidrug Resistant Bacterial Infections while Mitigating Drug Resistance Onset

Polymyxins remain the last line treatment for multidrug-resistant (MDR) infections. As polymyxins resistance emerges, there is an urgent need to develop effective antimicrobial agents capable of mitigating MDR. Here, we report biodegradable guanidinium-functionalized polycarbonates with a distinctive mechanism that does not induce drug resistance. Unlike conventional antibiotics, repeated use of the polymers does not lead to drug resistance. Transcriptomic analysis of bacteria further supports development of resistance to antibiotics but not to the macromolecules after 30 treatments. Importantly, high in vivo treatment efficacy of the macromolecules is achieved in MDR A. baumannii-, E. coli-, K. pneumoniae-, methicillin-resistant S. aureus-, cecal ligation and puncture-induced polymicrobial peritonitis, and P. aeruginosa lung infection mouse models while remaining non-toxic (e.g., therapeutic index—ED50/LD50: 1473 for A. baumannii infection). These biodegradable synthetic macromolecules have been demonstrated to have broad spectrum in vivo antimicrobial activity, and have excellent potential as systemic antimicrobials against MDR infections