Intraduodenal sarcoma recurrence of retroperitoneal origin: an unusual cause for a duodenal obstruction.

Soft tissue sarcomas are uncommon tumors, and intraduodenal soft tissue sarcoma manifestation is even more rare. Only three cases of intraduodenal sarcomas have been reported in the literature thus far. Here, we report a case of an intraduodenal recurrence of a retroperitoneal sarcoma causing bowel obstruction. This unusual recurrence pattern likely relates to the patient's previous resection and radiation treatment, and highlights the benefits, limitations and follow-up strategies after multimodality treatment

Machine Learning, Human Factors and Security Analysis for the Remote Command of Driving: An MCity Pilot

Conducted under the U.S. DOT Office of the Assistant Secretary for Research and Technology’s (OST-R) University Transportation Centers (UTC) program.Both human drivers and autonomous vehicles are able to drive relatively well in frequently encountered settings, but fail in exceptional cases. These exceptional cases often arise suddenly, leaving human drivers with a few seconds at best to react—exactly the setting that people perform worst in. Autonomous systems also fail in exceptional cases, because ambiguous situations preceding crashes are not effectively captured in training datasets. This work introduces new methods for leveraging groups of people to provide on-demand assistance by coordinating responses and using collective answer distributions to generate responses to ambiguous scenarios using minimal time and effort. Unlike prior approaches, we introduce collective workflows that enable groups of people to significantly outperform any of the constituent individuals in terms of time and accuracy. First, we examine the latency and accuracy of crowd workers in a future state prediction task in visual driving scenes, and find that more than 50% of workers could provide accurate answers within one second. We found that using crowd predictions is a viable approach for determining critical future states to inform rapid decision making. Additionally, we characterize different estimation techniques that can be used to efficiently create collective answer distributions from crowd workers for visual tasks containing ambiguity. Surprisingly, we discovered that the most fine-grained and time-consuming methods were not the most accurate. Instead, having annotators choose all relevant responses they thought other annotators would select led to more accurate aggregate outcomes. This approach reduced human time required by 21.4% while maintaining the same level of accuracy as the baseline approach. These research results can inform the development of hybrid intelligence systems that accurately and rapidly address sudden and rare critical events, even when they are ambiguous or subjective.United States Department of Transportation Office of the Assistant Secretary for Research and TechnologyCenter for Connected and Automated Transportationhttp://deepblue.lib.umich.edu/bitstream/2027.42/156392/4/Machine Learning Human Factors and Security Analysis for the Remote Command of Driving - An Mcity Pilot.pd

Magnetic fields in M dwarfs: rapid magnetic field variability in EV Lac

We report here our spectropolarimetric observations obtained using the Espadons/CFHT high resolution spectrograph of two M dwarf stars which standard models suggest are fully convective: EV Lac (M3.5) and HH And (M5.5). The difference in their rotational velocity makes them good targets to study the dependence of the magnetic field topology in M dwarfs on rotation. Our results reveal some aspects of the field topology in EV Lac and HH And. We measured mean longitudinal magnetic field strengths (Bz) in EV Lac ranging from 18+-3 G to -40+-3 G. The Bz variations are seen to occur in a timescale of less than 50 minutes, significantly shorter than the rotation period, and are not due to a flaring event. We discuss some formation scenarios of the Zeeman signatures found in EV Lac. For HH And we could not detect circular polarization and thus we place an upper limit to Bz of 5 G.Comment: Accepted by ApJ Letter

Flow analysis from multiparticle azimuthal correlations

We present a new method for analyzing directed and elliptic flow in heavy ion collisions. Unlike standard methods, it separates the contribution of flow to azimuthal correlations from contributions due to other effects. The separation relies on a cumulant expansion of multiparticle azimuthal correlations, and includes corrections for detector inefficiencies. This new method allows the measurement of the flow of identified particles in narrow phase-space regions, and can be used in every regime, from intermediate to ultrarelativistic energies.Comment: 31 pages, revtex. Published version (references added

Enhanced Electron Correlation and Significantly Suppressed Thermal Conductivity in Dirac Nodal-Line Metal Nanowires by Chemical Doping

Enhancing electron correlation in a weakly interacting topological system has great potential to promote correlated topological states of matter with extraordinary quantum properties. Here, the enhancement of electron correlation in a prototypical topological metal, namely iridium dioxide (IrO2), via doping with 3d transition metal vanadium is demonstrated. Single-crystalline vanadium-doped IrO2 nanowires are synthesized through chemical vapor deposition where the nanowire yield and morphology are improved by creating rough surfaces on substrates. Vanadium doping leads to a dramatic decrease in Raman intensity without notable peak broadening, signifying the enhancement of electron correlation. The enhanced electron correlation is further evidenced by transport studies where the electrical resistivity is greatly increased and follows an unusual √ T dependence on the temperature (T). The lattice thermal conductivity is suppressed by an order of magnitude via doping even at room temperature where phonon-impurity scattering becomes less important. Density functional theory calculations suggest that the remarkable reduction of thermal conductivity arises from the complex phonon dispersion and reduced energy gap between phonon branches, which greatly enhances phase space for phonon–phonon Umklapp scattering. This work demonstrates a unique system combining 3d and 5d transition metals in isostructural materials to enrich the system with various types of interactions

Early and persistent supershear rupture of the 2018 Mw 7.5 Palu earthquake

The speed at which an earthquake rupture propagates affects its energy balance and ground shaking impact. Dynamic models of supershear earthquakes, which are faster than the speed of shear waves, often start at subshear speed and later run faster than Eshelby’s speed. Here we present robust evidence of an early and persistent supershear rupture at the sub-Eshelby speed of the 2018 magnitude 7.5 Palu, Indonesia, earthquake. Slowness-enhanced back-projection of teleseismic data provides a sharp image of the rupture process, along a path consistent with the surface rupture trace inferred by subpixel correlation of synthetic-aperture radar and satellite optical images. The rupture propagated at a sustained velocity of 4.1 km s^(–1) from its initiation to its end, despite large fault bends. The persistent supershear speed is further validated by seismological evidence of far-field Rayleigh Mach waves. The unusual features of this earthquake probe the connections between the rupture dynamics and fault structure. An early supershear transition could be promoted by fault roughness near the hypocentre. Steady rupture propagation at a speed unexpected in homogeneous media could result from the presence of a low-velocity damaged fault zone

Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice

Ion channel-controlled cell volume regulation is of fundamental significance to the physiological function of sperm. In addition to volume regulation, LRRC8A-dependent volume-regulated anion channel (VRAC) activity is involved in cell cycle progression, insulin signaling, and cisplatin resistance. Nevertheless, the contribution of LRRC8A and its dependent VRAC activity in the germ cell lineage remain unknown. By utilizing a spontaneous Lrrc8a mouse mutation (c.1325delTG, p.F443*) and genetically engineered mouse models, we demonstrate that LRRC8A-dependent VRAC activity is essential for male germ cell development and fertility. Lrrc8a-null male germ cells undergo progressive degeneration independent of the apoptotic pathway during postnatal testicular development. Lrrc8a-deficient mouse sperm exhibit multiple morphological abnormalities of the flagella (MMAF), a feature commonly observed in the sperm of infertile human patients. Importantly, we identified a human patient with a rare LRRC8A hypomorphic mutation (c.1634G>A, p.Arg545His) possibly linked to Sertoli cell-only syndrome (SCOS), a male sterility disorder characterized by the loss of germ cells. Thus, LRRC8A is a critical factor required for germ cell development and volume regulation in the mouse, and it might serve as a novel diagnostic and therapeutic target for SCOS patients

Sex pheromone biosynthesis in the sugarcane borer Diatraea saccharalis: paving the way for biotechnological production.

peer reviewed[en] BACKGROUND: The sugarcane borer Diatraea saccharalis (Lepidoptera) is a key pest on sugarcane and other grasses in the Americas. Biological control as well as insecticide treatments are used for pest management, but economic losses are still significant. The use of female sex pheromones for mating disruption or mass trapping in pest management could be established for this species, provided that economical production of pheromone is available. RESULTS: Combining in vivo labelling studies, differential expression analysis of transcriptome data and functional characterisation of insect genes in a yeast expression system, we reveal the biosynthetic pathway and identify the desaturase and reductase enzymes involved in the biosynthesis of the main pheromone component (9Z,11E)-hexadecadienal, and minor components hexadecanal, (9Z)-hexadecenal and (11Z)-hexadecenal. We next demonstrate heterologous production of the corresponding alcohols of the pheromone components, by expressing multiple steps of the biosynthetic pathway in yeast. CONCLUSION: Elucidation of the genetic basis of sex pheromone biosynthesis in D. saccharalis, and heterologous expression in yeast, paves the way for biotechnological production of the pheromone compounds needed for pheromone-based pest management of this species