Prevalence of pathological Internet use among university students and correlations with self-esteem, the general health questionnaire (GHQ), and disinhibition

Over the last few years, there has been increased interest in the addictive potential of the Internet. The current study was an attempt to replicate common findings in the literature and provide more evidence for the existence of Internet addiction among students—a population considered to be especially vulnerable. A total of 371 British students responded to the questionnaire, which included the Pathological Internet Use (PIU) scale, the General Health Questionnaire (GHQ-12), a self-esteem scale, and two measures of disinhibition. Results showed that 18.3% of the sample were considered to be pathological Internet users, whose excessive use of the Internet was causing academic, social, and interpersonal problems. Other results showed that pathological Internet users had lower self-esteem and were more socially disinhibited. However, there was no significant difference in GHQ scores. These results are discussed in relation to the methodological shortcomings of research in the area as a whole

The impact of broadband in schools

The report reviews evidence for the impact of broadband in English schools, exploring; Variations in provision in level of broadband connectivity; Links between the level of broadband activity and nationally accessible performance data; Aspects of broadband connectivity and the school environment that contribute to better outcomes for pupils and teachers; Academic and motivational benefits associated with educational uses of this technology

Angular and radial correlation in doubly excited systems when 1 ≤ Z ≤ 4. The 2p2 3P state

The angular and radial components of electron correlation have each been examined in detail for the discrete 2p2 3P states of H-, He, Li+ and Be2+. These doubly excited systems were described by highly accurate explicitly correlated wavefunctions. The analysis involved the use of angular Coulomb holes, changes in the one- and two-particle radial density distributions and several angular and radial expectation values. Additionally, various statistical correlation coefficients were used which emphasized, in turn, angular and radial correlation properties in different regions of the two-particle density. The angular holes and related properties showed a clearly defined inverse-Z effect for He and the positive ions. This trend was not repeated for the radial curves. However, the radial densities did reveal a distinct \u27in-out\u27 correlation effect-similar in character to the split-shell behaviour for the ground state. By comparison with the findings for Z ≥ 2, the angular and radial correlation effects for H- were always exceedingly large, thus setting it apart from the other systems. For He, the angular hole for the comparatively slow moving 2p2 3P electrons was found to be over 50% deeper than that for the ground state and about six times the depth of a 1s2p 3P hole. The statistical correlation coefficients highlighted a steady growth, with Z, in the relative importance of angular correlation. Nevertheless, for each system, these coefficients indicated that the radial effect was the prevailing influence on the two-particle probability distribution

The doubly-excited state 2p 2 3P for 1 ≤ Z ≤ 4: Coulomb holes derived from explicitly correlated wavefunctions

Doubly-excited states (DES) of simple atoms involve, by comparison with the ground state, relatively slow moving electrons which should therefore be more responsive to electron correlation. Hence, for the 2p 23P state, correlation effects have been analyzed in detail in terms of Coulomb holes, partial Coulomb holes and (r n 12) when 1 ≤ Z ≤ 4. Comparisons are made with the 1s 2 1S ground state and with the singly-excited state 1s2p, 3P. As for the lower states, each DES was described by an accurate explicitly correlated wavefunction. For each Z, a similarity of characteristics, but not of scale, is found between the DES results and those for the ground state. The Coulomb holes for the 1s2p 3P states have a significantly different shape. The correlation effect for each DES system exceeds that for the corresponding lower states examined here. © 1992 IOP Pvblishing Ltd

Pneumococcal Colonisation Rates in Patients Admitted to a UK Hospital with Lower Respiratory Tract Infection - a prospective case-control study

BACKGROUND Current diagnostic tests are ineffective at identifying the aetiological pathogen in hospitalised adults with lower respiratory tract infection (LRTI). The association of pneumococcal colonisation with disease has been suggested as a means to increase diagnostic precision. We compared pneumococcal colonisation rate and density of nasal pneumococcal colonisation by a) classical culture and b) quantitative real time lytA Polymerase Chain Reaction (qPCR) in patients admitted to hospital in the UK with LRTI compared to control patients. METHODS 826 patients were screened for inclusion in this prospective case-control study. 38 patients were recruited, 19 with confirmed LRTI and 19 controls with another diagnosis. Nasal wash (NW) was collected at the time of recruitment. RESULTS Pneumococcal colonisation was detected in 1 LRTI patient and 3 controls (p=0.6) by classical culture. Using qPCR pneumococcal colonisation was detected in 10 LRTI patients and 8 controls (p=0.5). Antibiotic usage prior to sampling was significantly higher in the LRTI than control group 19 v. 3 (p8000 copies/ml on qPCR pneumococcal colonisation was found in 3 LRTI patients and 4 controls (p > 0.05). CONCLUSIONS We conclude that neither prevalence nor density of nasal pneumococcal colonisation (by culture and qPCR) can be used as a method of microbiological diagnosis in hospitalised adults with LRTI in the UK. A community based study recruiting patients prior to antibiotic therapy may be a useful future step

'Lad culture' in higher education: agency in the sexualisation debates

This paper reports on research funded by the National Union of Students, which explored women students’ experiences of ‘lad culture’ through focus groups and interviews. We found that although laddism is only one of various potential masculinities, for our participants it dominated social and sexual spheres of university life in problematic ways. However, their objections to laddish behaviours did not support contemporary models of ‘sexual panic’, even while oppugning the more simplistic celebrations of young women’s empowerment which have been observed in debates about sexualisation. We argue that in their ability to reject ‘lad culture’, our respondents expressed a form of agency which is often invisibilised in sexualisation discussions and which could be harnessed to tackle some of the issues we uncovered

Women, know your limits: Cultural sexism in academia

Despite the considerable advances of the feminist movement across Western societies, in Universities women are less likely to be promoted, or paid as much as their male colleagues, or even get jobs in the first place. One way in which we can start to reflect on why this might be the case is through hearing the experiences of women academics themselves. Using feminist methodology, this article attempts to unpack and explore just some examples of ‘cultural sexism’ which characterise the working lives of many women in British academia.This article uses qualitative methods to describe and make sense of just some of those experiences. In so doing, the argument is also made that the activity of academia is profoundly gendered and this explicit acknowledgement may contribute to our understanding of the under-representation of women in senior positions

Searching for compact objects in the single-lined spectroscopic binaries of the young Galactic cluster NGC 6231

Recent evolutionary computations predict that a few percent of massive OB stars in binary systems should have a dormant BH companion. Despite several reported X-ray quiet OB+BH systems over the last couple of years, finding them with certainty remains challenging. These have great importance as they can be gravitational wave (GW) source progenitors, and are landmark systems in constraining supernova kick physics. This work aims to characterise the hidden companions to the single-lined spectroscopic binaries (SB1s) in the B star population of the young open Galactic cluster NGC 6231 to find candidate systems for harbouring compact object companions. With the orbital solutions for each SB1 previously constrained, we applied Fourier spectral disentangling to multi-epoch optical VLT/FLAMES spectra of each target to extract a potential signature of a faint companion, and to identify newly disentangled double-lined spectroscopic binaries (SB2s). For targets where the disentangling does not reveal any signature of a stellar companion, we performed atmospheric and evolutionary modelling on the primary to obtain constraints on the unseen companion. Seven newly classified SB2 systems with mass ratios down to near 0.1 were identified. From the remaining targets, for which no faint companion could be extracted from the spectra, four are found to have companion masses in the predicted mass ranges of neutron stars (NSes) and BHes. Two of these have companion masses between 1 and 3.5 $M_{\odot}$, making them potential hosts of NSes (or lower mass main sequence stars). The other two are between 2.5 to 8 $M_{\odot}$ and 1.6 and 26 $M_{\odot}$, respectively, and so are identified as candidates for harbouring BH companions. However, unambiguous identification of these systems as X-ray quiet compact object harbouring binaries requires follow up observations.Comment: Submitted to A&

Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans

Rabies kills many people throughout the developing world every year. The murine monoclonal antibody (mAb) 62-71-3 was recently identified for its potential application in rabies postexposure prophylaxis (PEP). The purpose here was to establish a plant-based production system for a chimeric mouse-human version of mAb 62-71-3, to characterize the recombinant antibody and investigate at a molecular level its interaction with rabies virus glycoprotein. Chimeric 62-71-3 was successfully expressed in Nicotiana benthamiana. Glycosylation was analyzed by mass spectroscopy; functionality was confirmed by antigen ELISA, as well as rabies and pseudotype virus neutralization. Epitope characterization was performed using pseudotype virus expressing mutagenized rabies glycoproteins. Purified mAb demonstrated potent viral neutralization at 500 IU/mg. A critical role for antigenic site I of the glycoprotein, as well as for two specific amino acid residues (K226 and G229) within site I, was identified with regard to mAb 62-71-3 neutralization. Pseudotype viruses expressing glycoprotein from lyssaviruses known not to be neutralized by this antibody were the controls. The results provide the molecular rationale for developing 62-71-3 mAb for rabies PEP; they also establish the basis for developing an inexpensive plant-based antibody product to benefit low-income families in developing countries.—Both, L., van Dolleweerd, C., Wright, E., Banyard, A. C., Bulmer-Thomas, B., Selden, D., Altmann, F., Fooks, A. R., Ma, J. K.-C. Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans