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Evaluation of meaningful change in bowel move frequency for patients with carcinoid syndrome
The domestic and gendered context for retirement
Against a global backdrop of population and workforce ageing, successive UK governments have encouraged people to work longer and delay retirement. Debates focus mainly on factors affecting individuals’ decisions on when and how to retire. We argue that a fuller understanding of retirement can be achieved by recognizing the ways in which individuals’ expectations and behaviours reflect a complicated, dynamic set of interactions between domestic environments and gender roles, often established over a long time period, and more temporally proximate factors. Using a qualitative data set, we explore how the timing, nature and meaning of retirement and retirement planning are played out in specific domestic contexts. We conclude that future research and policies surrounding retirement need to: focus on the household, not the individual; consider retirement as an often messy and disrupted process and not a discrete event; and understand that retirement may mean very different things for women and for men
Limit Cycles in Four Dimensions
We present an example of a limit cycle, i.e., a recurrent flow-line of the
beta-function vector field, in a unitary four-dimensional gauge theory. We thus
prove that beta functions of four-dimensional gauge theories do not produce
gradient flows. The limit cycle is established in perturbation theory with a
three-loop calculation which we describe in detail.Comment: 12 pages, 1 figure. Significant revision of the interpretation of our
result. Improved description of three-loop calculatio
The reliability of a breath‐hold protocol to determine cerebrovascular reactivity in adolescents
This is the published version. Available on open access from Wiley via the DOI in this recordPurpose
Cerebrovascular reactivity (CVR) is impaired in adolescents with cardiovascular disease risk factors. A breath‐hold test is a noninvasive method of assessing CVR, yet there are no reliability data of this outcome in youth. This study aimed to assess the reliability of a breath‐hold protocol to measure CVR in adolescents.
Methods
Twenty‐one 13 to 15 year old adolescents visited the laboratory on two separate occasions, to assess the within‐test, within‐day and between‐day reliability of a breath‐hold protocol, consisting of three breath‐hold attempts. CVR was defined as the relative increase from baseline in middle cerebral artery mean blood velocity following a maximal breath‐hold of up to 30 seconds, quantified via transcranial Doppler ultrasonography.
Results
Mean breath‐hold duration and CVR were never significantly correlated (r .08). The within‐test coefficient of variation for CVR was 15.2%, with no significant differences across breath‐holds (P = .88), so the three breath‐hold attempts were averaged for subsequent analyses. The within‐ and between‐day coefficients of variation for CVR were 10.8% and 15.3%, respectively.
Conclusions
CVR assessed via a three breath‐hold protocol can be reliably measured in adolescents, yielding similar within‐ and between‐day reliability. Analyses revealed that breath‐hold length and CVR were unrelated, indicating the commonly reported normalization of CVR to breath‐hold duration (breath‐hold index) may be unnecessary in youth
All clinically-relevant blood components transmit prion disease following a single blood transfusion: a sheep model of vCJD
Variant CJD (vCJD) is an incurable, infectious human disease, likely arising from the consumption of BSE-contaminated meat products. Whilst the epidemic appears to be waning, there is much concern that vCJD infection may be perpetuated in humans by the transfusion of contaminated blood products. Since 2004, several cases of transfusion-associated vCJD transmission have been reported and linked to blood collected from pre-clinically affected donors. Using an animal model in which the disease manifested resembles that of humans affected with vCJD, we examined which blood components used in human medicine are likely to pose the greatest risk of transmitting vCJD via transfusion. We collected two full units of blood from BSE-infected donor animals during the pre-clinical phase of infection. Using methods employed by transfusion services we prepared red cell concentrates, plasma and platelets units (including leucoreduced equivalents). Following transfusion, we showed that all components contain sufficient levels of infectivity to cause disease following only a single transfusion and also that leucoreduction did not prevent disease transmission. These data suggest that all blood components are vectors for prion disease transmission, and highlight the importance of multiple control measures to minimise the risk of human to human transmission of vCJD by blood transfusion
Model-Independent Bounds on a Light Higgs
We present up-to-date constraints on a generic Higgs parameter space. An
accurate assessment of these exclusions must take into account statistical, and
potentially signal, fluctuations in the data currently taken at the LHC. For
this, we have constructed a straightforward statistical method for making full
use of the data that is publicly available. We show that, using the expected
and observed exclusions which are quoted for each search channel, we can fully
reconstruct likelihood profiles under very reasonable and simple assumptions.
Even working with this somewhat limited information, we show that our method is
sufficiently accurate to warrant its study and advocate its use over more naive
prescriptions. Using this method, we can begin to narrow in on the remaining
viable parameter space for a Higgs-like scalar state, and to ascertain the
nature of any hints of new physics---Higgs or otherwise---appearing in the
data.Comment: 32 pages, 10 figures; v3: correction made to basis of four-derivative
operators in the effective Lagrangian, references adde
A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone
Recommended standardized procedures for determining exhaled lower respiratory
nitric oxide and nasal nitric oxide have been developed by task forces of the
European Respiratory Society and the American Thoracic Society. These
recommendations have paved the way for the measurement of nitric oxide to
become a diagnostic tool for specific clinical applications. It would be
desirable to develop similar guidelines for the sampling of other trace gases
in exhaled breath, especially volatile organic compounds (VOCs) which reflect
ongoing metabolism. The concentrations of water-soluble, blood-borne substances
in exhaled breath are influenced by: (i) breathing patterns affecting gas
exchange in the conducting airways; (ii) the concentrations in the
tracheo-bronchial lining fluid; (iii) the alveolar and systemic concentrations
of the compound. The classical Farhi equation takes only the alveolar
concentrations into account. Real-time measurements of acetone in end-tidal
breath under an ergometer challenge show characteristics which cannot be
explained within the Farhi setting. Here we develop a compartment model that
reliably captures these profiles and is capable of relating breath to the
systemic concentrations of acetone. By comparison with experimental data it is
inferred that the major part of variability in breath acetone concentrations
(e.g., in response to moderate exercise or altered breathing patterns) can be
attributed to airway gas exchange, with minimal changes of the underlying blood
and tissue concentrations. Moreover, it is deduced that measured end-tidal
breath concentrations of acetone determined during resting conditions and free
breathing will be rather poor indicators for endogenous levels. Particularly,
the current formulation includes the classical Farhi and the Scheid series
inhomogeneity model as special limiting cases.Comment: 38 page
The acute and postprandial effects of sugar moiety on vascular and metabolic health outcomes in adolescents
This is the author accepted manuscript. The final version is available from Canadian Science Publishing via the DOI in this recordThis study explored the cardiometabolic responses to sugar moieties acutely, and following a
subsequent mixed meal tolerance test (MMTT). Twenty-one healthy adolescents (N=10
female, 14.3±0.4 years) completed three experimental and one control condition, in a
counterbalanced order. These consisted of different drinks to compare the effect of 300 mL of
water (control), or 300 mL of water mixed with 60 g of glucose, fructose or sucrose, on vascular
function (flow-mediated dilation; FMD, microvascular reactivity (total hyperaemic response;
TRH); and cerebrovascular reactivity; CVR), and blood samples for [uric acid], [glucose],
[triglycerides] and [lactate]. FMD increased 1 hour after glucose and sucrose (P<0.001,
ES≥0.92) but was unchanged following fructose and water (P>0.19, ES>0.09). CVR and TRH
were unchanged 1 hour following all conditions (P>0.57, ES>0.02). Following the MMTT, FMD
was impaired in all conditions (P0.40) with no differences between conditions
(P>0.13, ES<0.39). Microvascular TRH was increased in all conditions (P=0.001, ES=0.88),
and CVR was preserved in all conditions post MMTT (P=0.87, ES=0.02). Blood [uric acid] was
elevated following fructose consumption and the MMTT (P0.40). Consumption of a
sugar sweetened beverage did not result in vascular dysfunction in healthy adolescents,
however the vascular and metabolic responses were dependent on sugar moiety
Minimal Conformal Technicolor and Precision Electroweak Tests
We study the minimal model of conformal technicolor, an SU(2) gauge theory
near a strongly coupled conformal fixed point, with conformal symmetry softly
broken by technifermion mass terms. Conformal symmetry breaking triggers chiral
symmetry breaking in the pattern SU(4) -> Sp(4), which gives rise to a
pseudo-Nambu-Goldstone boson that can act as a composite Higgs boson. The top
quark is elementary, and the top and electroweak gauge loop contributions to
the Higgs mass are cut off entirely by Higgs compositeness. In particular, the
model requires no top partners and no "little Higgs" mechanism. A nontrivial
vacuum alignment results from the interplay of the top loop and technifermion
mass terms. The composite Higgs mass is completely determined by the top loop,
in the sense that m_h/m_t is independent of the vacuum alignment and is
computable by a strong-coupling calculation. There is an additional composite
pseudoscalar A with mass larger than m_h and suppressed direct production at
LHC. We discuss the electroweak fit in this model in detail. Corrections to Z
-> bb and the T parameter from the top sector are suppressed by the enhanced
Sp(4) custodial symmetry. Even assuming that the strong contribution to the S
parameter is positive and usuppressed, a good electroweak fit can be obtained
for v/f ~ 0.25, where v and f are the electroweak and chiral symmetry breaking
scales respectively. This requires fine tuning at the 10% level.Comment: 34 pages, 4 figures; v2: updated precision electroweak fi
The future burden of lung cancer attributable to current modifiable behaviours: a pooled study of seven Australian cohorts
BACKGROUND: Knowledge of preventable disease and differences in disease burden can inform public health action to improve health and health equity. We quantified the future lung cancer burden preventable by behavioural modifications across Australia. METHODS: We pooled seven Australian cohort studies (n = 367 058) and linked them to national registries to identify lung cancers and deaths. We estimated population attributable fractions and their 95% confidence intervals (CIs) for modifiable risk factors, using risk estimates from the cohort data and risk factor exposure distribution from contemporary national health surveys. RESULTS: During the first 10-year follow-up, there were 2025 incident lung cancers and 20 349 deaths. Stopping current smoking could prevent 53.7% (95% CI, 50.0-57.2%) of lung cancers over 40 years and 18.3% (11.0-25.1%) in 10 years. The smoking-attributable burden is highest in males, those who smoke <20 cigarettes per day, are <75 years of age, unmarried, of lower educational attainment, live in remote areas or are healthy weight. Increasing physical activity and fruit consumption, if causal, could prevent 15.6% (6.9-23.4%) and 7.5% (1.3-13.3%) of the lung cancer burden, respectively. Jointly, the three behaviour modifications could prevent up to 63.0% (58.0-67.5%) of lung cancers in 40 years, and 31.2% (20.9-40.1%) or 43 300 cancers in 10 years. The preventable burden is highest among those with multiple risk factors. CONCLUSIONS: Smoking remains responsible for the highest burden of lung cancer in Australia. The uneven burden distribution distinguishes subgroups that could benefit the most from activities to control the world's deadliest cancer
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