Widespread presentation and spontaneous regression of porokeratotic eccrine ostial and dermal duct nevus

Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is an uncommon hamartomatous growth with disordered keratinization. The lesions typically appear on the limbs, often at birth or in early childhood, as linearly distributed papules and plaques. We report 4 cases of PEODDN, 2 of which showed significant spontaneous regression

Sarcoid-like reaction in a patient recovering from coronavirus disease 19 pneumonia

As coronavirus disease 2019 (COVID-19) cases continue to increase, so do the reported extrapulmonary manifestations of this disease. To date, described dermatologic manifestations of COVID-19 include pernio-like acral nodules, dengue fever–like petechiae, vesiculobullous eruptions, pityriasis rosea and viral-like exanthems, retiform purpura, and livedo reticularis.1 We describe a patient with new-onset, biopsy confirmed sarcoid-like reaction in the setting of COVID-19 pneumonia and postulate a role for this immunologic reaction in hastening disease recovery

Genetic Engineering in Streptomyces roseosporus to Produce Hybrid Lipopeptide Antibiotics

SummaryDaptomycin is a lipopeptide antibiotic produced by a nonribosomal peptide synthetase (NRPS) in Streptomyces roseosporus. The holoenzyme is composed of three subunits, encoded by the dptA, dptBC, and dptD genes, each responsible for incorporating particular amino acids into the peptide. We introduced expression plasmids carrying dptD or NRPS genes encoding subunits from two related lipopeptide biosynthetic pathways into a daptomycin nonproducing strain of S. roseosporus harboring a deletion of dptD. All constructs successfully complemented the deletion in trans, generating three peptide cores related to daptomycin. When these were coupled with incomplete methylation of 1 amino acid and natural variation in the lipid side chain, 18 lipopeptides were generated. Substantial amounts of nine of these compounds were readily obtained by fermentation, and all displayed antibacterial activity against gram-positive pathogens

Concert recording 2017-10-12

[Track 1]. Concertino for trombone, op. 4. I. Allegro maestoso / Ferdinand David -- [Track 2]. Sonata for trombone and piano. II. Andante molto sostenuto I. Allegro / Kazimierz Serocki -- [Track 3]. Selections from Pictures at an exhibition. Bydlo Promenade / Modest Mussorgsky arranged by Kenneth Gehrs -- [Track 4]. A winter\u27s night / Kevin McKee -- [Track 5]. Sonata for bass trombone. II. Andantino I. Allegro non troppo / Patrick McCarty -- [Track 6]. Achieved is the glorious work from Creation / Franz Joseph Haydn -- [Track 7]. Etude no. 15 / Marco Bordogni -- [Track 8]. Suite for four trombones. I. Intrada VI. Arietta III. Interludium / Serocki