Bond strength of dental nanocomposites repaired with a bulkfill composite

The aim of this study was to analyze the bond strength of aged resin based nanocomposites repaired with the same and bulk fill composites. Seventy-two disc shaped resin composites consisted of three different nanocomposite resins (Filtek Ultimate/FU, Herculite XRV Ultra/HXRV, and Reflectys/R) were produced. After storing the samples for 8 weeks in distilled water, each material was combined with the same material or the bulk-fill composite resin system (Filtek Ultimate+Filtek Ultimate/Group-1; Filtek Ultimate+Tetric BF/Group-2; Herculite XRV+Herculite XRV/Group-3; Herculite XRV+Tetric BF/ Group-4; Reflectys+Reflectys/Group 5; Reflectys+Tetric BF/Group-6), for repair. Then specimens were subjected to shear bond strength testing(SBS), and the debonded surfaces were examined. There was a significant difference among three materials(repaired with itself+bulk fill) for SBS testing values (p=0.001). FU and R were found to be similar, while HXRV was significantly different from them. A significant difference between group-1 and 2 (p=0.006) was detected, while there were no differences between group 3 and 4 (p= 0.142), and 5 and 6 (p=0.346). Among the six groups, repair SBS testing values with TBF were higher than repair with itself except for FU. The bulk-fill repaired materials showed higher bond strength except for FU, which showed the highest SBS value when repaired with itself. An increased incidence of adhesive fracture was observed at low strengths

Evaluation of Serum and Salivary Lipid Peroxidation Levels According to Periodontitis Type

Aim: In this study, we aimed to investigate the role of malondialdehyde (MDA) in the pathophysiology of periodontitis by examining serum and salivary MDA levels in patients with advanced periodontitis and healthy individuals according to the periodontal disease classification revised in the workshop held by the American Association of Chartered Epidemiologists and the European Federation in 2017. Methods: The study was designed as a cross-sectional study, and a total of 37 patients who applied to Karadeniz Technical University Faculty of Dentistry, Department of Periodontology, in 2022 for periodontal disorders or controls were included. A total of 37 individuals, aged 25-48 years, with stage III grade C periodontitis (Group 1; 13 patients), stage IV grade C periodontitis (Group 2; 12 patients), and a periodontally healthy group (Group 3; 12 individuals) were included in the study. After the demographic characteristics and body mass index (BMI) data were obtained, the clinical periodontal parameters and serum and saliva MDA values of the individuals were measured. All the obtained data were statistically analyzed. Results: Although BMI was lower and education level was higher in the controls (p<0.034), other demographic characteristics did not differ between the groups. When the clinical periodontal parameters were examined, the lowest values were observed in the controls, whereas the highest values were observed in stage IV. The difference between all three groups was statistically significant (p=0.000). Although serum MDA levels did not differ between the groups, the highest MDA level was observed in stage III, and the lowest MDA level was observed in the controls. In addition, salivary MDA levels did not differ between the groups, with the highest MDA level observed in stage III and the lowest MDA level observed in stage IV. Conclusion: The findings of our study showed that systemic and local lipid peroxidation levels increased/decreased in individuals with advanced periodontitis compared with the periodontal healthy group, but this change was not statistically significant. Our findings suggest that different oxidative stress mechanisms may also be involved in advanced periodontitis

A new framework for supply chain risk management through supply chain management capability

Supply chain risk management is considered as one of the most powerful competitive tools for the companies. Therefore, the concept has caught the attention of researchers especially in the recent years. However, supply chain risk management has not been examined in the literature by considering the maturity and capability levels of supply chain members. This study aims to address this gap and develops a new framework on supply chain risk management which focuses on different supply chain orientation levels of the supply chains members. The framework proposed in this study is named as “Supply Chain Management Capability Model”. This model is the first attempt to illustrate the required supply chain risk management capabilities of companies for different supply chain orientation levels. This model presents developing supply chain structures with increasing orientation levels, which also serve for Business to Business (B2B) and relationship marketing purposes. The results of this study show that supply chain members’ capability levels also vary in terms of sustainability dimension. The results of the study provide relevant findings both to guide practitioners and motivate researchers to conduct further studies in this are

Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men

Objective  This study was conducted to assess the effects of chronic daily methylsulfonylmethane (MSM) supplementation on known markers of oxidative stress following acute bouts of exercise in untrained healthy young men. Methods  Eighteen untrained men volunteered for this study. Participants were randomized in a double-blind placebo-controlled fashion into two groups: MSM (n = 9) and placebo (n = 9). The participants took supplementation or placebo daily for 10 days before running. Participants ran 14 km. The MSM supplementation was prepared in water at 50 mg/kg body weight. The placebo group received water. Serum malondialdehyde (MDA), protein carbonyl (PC) and plasma oxidized glutathione (GSSG) were measured as markers of oxidative stress. The plasma-reduced glutathione (GSH) level and the GSH/GSSG ratio were determined as markers of plasma antioxidant capacity. Key Findings  Acute exercise led to elevated levels of serum MDA, PC and plasma GSSG. MSM supplementation maintained PC, MDA and GSSG at lower levels after exercise than the placebo. The plasma level of GSH and the ratio of GSH/GSSG were significantly higher in the MSM supplemented group. Conclusions  These results suggest that chronic daily oral supplementation of MSM has alleviating effects on known markers of oxidative stress following acute bouts of exercise in healthy young men

Safety and Efficacy of the FRED Jr Flow Re-Direction Endoluminal Device for Intracranial Aneurysms: Retrospective Multicenter Experience With Emphasis on Midterm Results

Background and Purpose: Flow diversion is increasingly used as an endovascular treatment for intracranial aneurysms. In this retrospective multicenter study, we analyzed the safety and efficacy of the treatment of intracranial, unruptured, or previously treated but recanalized aneurysms using Flow Re-Direction Endoluminal Device (FRED) Jr with emphasis on midterm results. Materials and Methods: Clinical and radiological records of 150 patients harboring 159 aneurysms treated with FRED Jr at six centers between October 2014 and February 2020 were reviewed and consecutively included. Clinical outcome was measured by using the modified Rankin Scale (mRS). Anatomical results were assessed according to the O’Kelly-Marotta (OKM) scale and the Cekirge-Saatci Classification (CSC) scale. Results: The overall complication rate was 24/159 (16%). Thrombotic-ischemic events occurred in 18/159 treatments (11%). These resulted in long-term neurological sequelae in two patients (1%) with worsening from pre-treatment mRS 0–2 and mRS 4 after treatment. Complete or near-complete occlusion of the treated aneurysm according to the OKM scale was reached in 54% (85/158) at 6-month, in 68% (90/133) at 1-year, and in 83% (77/93) at 2-year follow-up, respectively. The rates of narrowing or occlusion of a vessel branch originating from the treated aneurysm according to the CSC scale were 11% (12/108) at 6-month, 20% (17/87) at 1-year, and 23% (13/57) at 2-year follow-up, respectively, with all cases being asymptomatic. Conclusions: In this retrospective multicenter study, FRED Jr was safe and effective in the midterm occlusion of cerebral aneurysms. Most importantly, it was associated with a high rate of good clinical outcome

Stent-Graft Treatment of Patients with Acute Bleeding from Hepatic Artery Branches

To present a new treatment option in patients with acute bleeding from the hepatic artery branches.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41326/1/270_2004_Article_56.pd

Autophagy in periodontitis patients and gingival fibroblasts: unraveling the link between chronic diseases and inflammation

Authors are indebted with Ms Monica Glebocki for extensive editing of the manuscriptBackground: Periodontitis, the most prevalent chronic inflammatory disease, has been related to cardiovascular diseases. Autophagy provides a mechanism for the turnover of cellular organelles and proteins through a lysosome-dependent degradation pathway. The aim of this research was to study the role of autophagy in peripheral blood mononuclear cells from patients with periodontitis and gingival fibroblasts treated with a lipopolysaccharide of Porphyromonas gingivalis. Autophagy-dependent mechanisms have been proposed in the pathogenesis of inflammatory disorders and in other diseases related to periodontitis, such as cardiovascular disease and diabetes. Thus it is important to study the role of autophagy in the pathophysiology of periodontitis. Methods: Peripheral blood mononuclear cells from patients with periodontitis (n = 38) and without periodontitis (n = 20) were used to study autophagy. To investigate the mechanism of autophagy, we evaluated the influence of a lipopolysaccharide from P. gingivalis in human gingival fibroblasts, and autophagy was monitored morphologically and biochemically. Autophagosomes were observed by immunofluorescence and electron microscopy. Results: We found increased levels of autophagy gene expression and high levels of mitochondrial reactive oxygen species production in peripheral blood mononuclear cells from patients with periodontitis compared with controls. A significantly positive correlation between both was observed. In human gingival fibroblasts treated with lipopolysaccharide from P. gingivalis, there was an increase of protein and transcript of autophagy-related protein 12 (ATG12) and microtubule-associated protein 1 light chain 3 alpha LC3. A reduction of mitochondrial reactive oxygen species induced a decrease in autophagy whereas inhibition of autophagy in infected cells increased apoptosis, showing the protective role of autophagy. Conclusion: Results from the present study suggest that autophagy is an important and shared mechanism in other conditions related to inflammation or alterations of the immune system, such as periodontiti

The Distributer\u27s Three-Dimensional Pallet-Packing Problem: A Human Intelligence-Based Heuristic Approach

The Distributor\u27s Pallet Packing Problem is to load a set of distinct boxes with given dimensions on pallets or in containers to maximize volume utilization. This problem is still in its early stages of research, but there is a high level of interest in developing effective models to solve this NP-hard problem to reduce the time, energy and other resources spent in packing pallets. In its search to improve operations, the Air Force is also making an effort to solve this problem. Building an analytical model and developing a genetic algorithm approach have been tried, but the problem needs more research and there is a need to produce realistic solutions in a reasonable amount of time. We develop a special heuristic algorithm and code it in the C programming language. In our model, we used powerful heuristic tools and dynamic data structure to mimic human behavior, providing a new solution approach to pallet packing. We created another program to visualize packing results. Tests on hundreds of problems show that our model makes the most of volume utilization in minimal time making it a leader among presented and published works

OPTIMIZATION OF MICROWAVE AND AIR DRYING CONDITIONS OF QUINCE (CYDONIA OBLONGA, MILLER) USING RESPONSE SURFACE METHODOLOGY

Effects of slice thickness of quince (Cydonia oblonga Miller) , microwave incident power and air drying temperature on antioxidant activity and total phenolic content of quince were investigated during drying in microwave and air drying. Optimum conditions were found to be: i) for microwave drying, 285 W and 4.14 mm thick (maximum antioxidant activity) and 285 W and 6.85 mm thick (maximum total phenolic content), and ii) for air drying, 75 ºC and 1.2 mm thick (both maximum antioxidant activity and total phenolic content). Drying conditions were optimized by using the response surface methodology. 13 experiments were carried out considering incident microwave powers from 285 to 795 W, air temperature from 46 to 74 ºC and slice thickness from 1.2 to 6.8 mm