29 research outputs found
Randomly dilute Ising model: A nonperturbative approach
The N-vector cubic model relevant, among others, to the physics of the
randomly dilute Ising model is analyzed in arbitrary dimension by means of an
exact renormalization-group equation. This study provides a unified picture of
its critical physics between two and four dimensions. We give the critical
exponents for the three-dimensional randomly dilute Ising model which are in
good agreement with experimental and numerical data. The relevance of the cubic
anisotropy in the O(N) model is also treated.Comment: 4 pages, published versio
Wang-Landau study of the 3D Ising model with bond disorder
We implement a two-stage approach of the Wang-Landau algorithm to investigate
the critical properties of the 3D Ising model with quenched bond randomness. In
particular, we consider the case where disorder couples to the nearest-neighbor
ferromagnetic interaction, in terms of a bimodal distribution of strong versus
weak bonds. Our simulations are carried out for large ensembles of disorder
realizations and lattices with linear sizes in the range . We apply
well-established finite-size scaling techniques and concepts from the scaling
theory of disordered systems to describe the nature of the phase transition of
the disordered model, departing gradually from the fixed point of the pure
system. Our analysis (based on the determination of the critical exponents)
shows that the 3D random-bond Ising model belongs to the same universality
class with the site- and bond-dilution models, providing a single universality
class for the 3D Ising model with these three types of quenched uncorrelated
disorder.Comment: 7 pages, 7 figures, to be published in Eur. Phys. J.
25th-order high-temperature expansion results for three-dimensional Ising-like systems on the simple cubic lattice
25th-order high-temperature series are computed for a general
nearest-neighbor three-dimensional Ising model with arbitrary potential on the
simple cubic lattice. In particular, we consider three improved potentials
characterized by suppressed leading scaling corrections. Critical exponents are
extracted from high-temperature series specialized to improved potentials,
obtaining , , ,
, , . Moreover, biased
analyses of the 25th-order series of the standard Ising model provide the
estimate for the exponent associated with the leading scaling
corrections. By the same technique, we study the small-magnetization expansion
of the Helmholtz free energy. The results are then applied to the construction
of parametric representations of the critical equation of state, using a
systematic approach based on a global stationarity condition. Accurate
estimates of several universal amplitude ratios are also presented.Comment: 40 pages, 15 figure
Critical exponents and equation of state of the three-dimensional Heisenberg universality class
We improve the theoretical estimates of the critical exponents for the
three-dimensional Heisenberg universality class. We find gamma=1.3960(9),
nu=0.7112(5), eta=0.0375(5), alpha=-0.1336(15), beta=0.3689(3), and
delta=4.783(3). We consider an improved lattice phi^4 Hamiltonian with
suppressed leading scaling corrections. Our results are obtained by combining
Monte Carlo simulations based on finite-size scaling methods and
high-temperature expansions. The critical exponents are computed from
high-temperature expansions specialized to the phi^4 improved model. By the
same technique we determine the coefficients of the small-magnetization
expansion of the equation of state. This expansion is extended analytically by
means of approximate parametric representations, obtaining the equation of
state in the whole critical region. We also determine a number of universal
amplitude ratios.Comment: 40 pages, final version. In publication in Phys. Rev.
Antiparasite treatments reduce humoral immunity and impact oxidative status in raptor nestlings
Parasites are natural stressors that may have multiple negative effects on their hos as they usurp energy and nutrients and may lead to costly immune responses that may cause oxidative stress. At early stages, animals may be more sensitive to infectious organisms because of their rapid growth and partly immature immune system. The objective of this study was to explore effects of parasites by treating chicks of two raptor species (northern goshawk Accipiter gentilis and whiteâtailed sea eagle Haliaeetus albicilla) against both endoparasites (internal parasites) and ectoparasites (external parasites). Nests were either treated against ectoparasites by spraying with pyrethrin or left unsprayed as control nests. Within each nest, chicks were randomly orally treated with either an antihelminthic medication (fenbendazole) or sterile water as control treatment. We investigated treatment effects on plasma (1) total antioxidant capacity TAC (an index of nonenzymatic circulating antioxidant defenses), (2) total oxidant status TOS (a measure of plasmatic oxidants), and (3) immunoglobulin levels (a measure of humoral immune function). Treatment against ectoparasites led to a reduction in circulating immunoglobulin plasma levels in male chicks. TOS was higher when not receiving any parasite reduction treatment and when receiving both endoâ and ectoparasitic reduction treatment compared with receiving only one treatment. TAC was higher in all treatment groups, when compared to controls. Despite the relatively low sample size, this experimental study suggests complex but similar relationships between treatment groups and oxidative status and immunoglobulin levels in two raptor species
Gravitational Collapse and Disk Formation in Magnetized Cores
We discuss the effects of the magnetic field observed in molecular clouds on
the process of star formation, concentrating on the phase of gravitational
collapse of low-mass dense cores, cradles of sunlike stars. We summarize recent
analytic work and numerical simulations showing that a substantial level of
magnetic field diffusion at high densities has to occur in order to form
rotationally supported disks. Furthermore, newly formed accretion disks are
threaded by the magnetic field dragged from the parent core during the
gravitational collapse. These disks are expected to rotate with a sub-Keplerian
speed because they are partially supported by magnetic tension against the
gravity of the central star. We discuss how sub-Keplerian rotation makes it
difficult to eject disk winds and accelerates the process of planet migration.
Moreover, magnetic fields modify the Toomre criterion for gravitational
instability via two opposing effects: magnetic tension and pressure increase
the disk local stability, but sub-Keplerian rotation makes the disk more
unstable. In general, magnetized disks are more stable than their nonmagnetic
counterparts; thus, they can be more massive and less prone to the formation of
giant planets by gravitational instability.Comment: Chapter 16 in "Magnetic Fields in Diffuse Media", Springer-Verlag,
eds. de Gouveia Dal Pino, E., Lazarian, A., Melioli,
Application of a risk-management framework for integration of stromal tumor-infiltrating lymphocytes in clinical trials
Stromal tumor-infiltrating lymphocytes (sTILs) are a potential predictive biomarker for immunotherapy response in metastatic triple-negative breast cancer (TNBC). To incorporate sTILs into clinical trials and diagnostics, reliable assessment is essential. In this review, we propose a new concept, namely the implementation of a risk-management framework that enables the use of sTILs as a stratification factor in clinical trials. We present the design of a biomarker risk-mitigation workflow that can be applied to any biomarker incorporation in clinical trials. We demonstrate the implementation of this concept using sTILs as an integral biomarker in a single-center phase II immunotherapy trial for metastatic TNBC (TONIC trial, NCT02499367), using this workflow to mitigate risks of suboptimal inclusion of sTILs in this specific trial. In this review, we demonstrate that a web-based scoring platform can mitigate potential risk factors when including sTILs in clinical trials, and we argue that this framework can be applied for any future biomarker-driven clinical trial setting
Inter-population synchrony in adult survival and effects of climate and extreme weather in non-breeding areas of Atlantic puffins
Seabirds are undergoing drastic declines globally and spend the non-breeding season at sea, making it challenging to study the drivers of their survival. Harsh weather and changes in climate conditions can have large impacts on seabird population dynamics through increased mortality. The intensity and persistence of extreme events are forecasted to increase with global warming. As shared conditions can induce population synchrony, multi-population studies of key demographic parameters are imperative to explore the influence of climate change. We used long-term mark-recapture data and position data to determine non-breeding stop-over areas of five Atlantic puffin (Fratercula arctica) populations over a latitudinal gradient in the north-eastern Atlantic (56°11ââ70°23âN). We investigated synchrony in adult survival in relation to shared stop-over areas. We quantified effects of extreme extra-tropical cyclones (ETCs) specific to populationsâ stop-over areas and the North Atlantic Oscillation on adult survival. Populations with overlapping stop-over areas exhibited temporal synchrony in survival rates. Winter ETCs negatively influenced survival in one population, which was the one most exposed to extreme weather, but did not directly influence adult survival in the other four populations. Synchrony among populations with shared stop-over areas highlights the importance of these areas for adult survival, a key life-history rate. However, extreme weather was not identified as a driving factor for four of the populations. This suggests other factors in these areas, likely related to bottom-up trophic interactions, as environmental drivers of synchrony in the survival of Atlantic puffins
Immunocompromised patients with acute respiratory distress syndrome : Secondary analysis of the LUNG SAFE database
The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013