In vitro measurement of nucleus pulposus swelling pressure: A new technique for studies of spinal adaptation to gravity

Swelling of the intervertebral disc nucleus pulposus is altered by posture and gravity. We have designed and tested a new osmometer for in vitro determination of nucleus pulposus swelling pressure. The functional principle of the osmometer involves compressing a sample of nucleus pulposus with nitrogen gas until saline pressure gradients across a 0.45 microns Millipore filter are eliminated. Swelling pressure of both pooled dog and pooled pig lumbar disc nucleus pulposus were measured on the new osmometer and compared to swelling pressures determined using the equilibrium dialysis technique. The osmometer measured swelling pressures comparable to those obtained by the dialysis technique. This osmometer provides a rapid, direct, and accurate measurement of swelling pressure of the nucleus pulposus

Surfactant status and respiratory outcome in premature infants receiving late surfactant treatment.

BACKGROUND:Many premature infants with respiratory failure are deficient in surfactant, but the relationship to occurrence of bronchopulmonary dysplasia (BPD) is uncertain. METHODS:Tracheal aspirates were collected from 209 treated and control infants enrolled at 7-14 days in the Trial of Late Surfactant. The content of phospholipid, surfactant protein B, and total protein were determined in large aggregate (active) surfactant. RESULTS:At 24 h, surfactant treatment transiently increased surfactant protein B content (70%, p < 0.01), but did not affect recovered airway surfactant or total protein/phospholipid. The level of recovered surfactant during dosing was directly associated with content of surfactant protein B (r = 0.50, p < 0.00001) and inversely related to total protein (r = 0.39, p < 0.0001). For all infants, occurrence of BPD was associated with lower levels of recovered large aggregate surfactant, higher protein content, and lower SP-B levels. Tracheal aspirates with lower amounts of recovered surfactant had an increased proportion of small vesicle (inactive) surfactant. CONCLUSIONS:We conclude that many intubated premature infants are deficient in active surfactant, in part due to increased intra-alveolar metabolism, low SP-B content, and protein inhibition, and that the severity of this deficit is predictive of BPD. Late surfactant treatment at the frequency used did not provide a sustained increase in airway surfactant

Weighted Silks Observed Using Energy Dispersive X-Ray Spectrometry

A group of modern silk fabrics was treated with various weighting agents as standards. These standards were observed using energy dispersive x-ray spectrometry. The standards were compared to untreated samples and to museum specimens of weighted silks. In all prepared specimens the elements expected from treatment were observed; weighting treatments could be distinguished. The analytical procedures are discussed and compared to recent work on mordant analysis using the same techniques

Cosmic-ray Acceleration at Ultrarelativistic Shock Waves: Effects of a "Realistic" Magnetic Field Structure

First-order Fermi acceleration processes at ultrarelativistic shocks are studied with Monte Carlo simulations. The accelerated particle spectra are derived by integrating the exact particle trajectories in a turbulent magnetic field near the shock. ''Realistic'' features of the field structure are included. We show that the main acceleration process at superluminal shocks is the particle compression at the shock. Formation of energetic spectral tails is possible in a limited energy range only for highly perturbed magnetic fields, with cutoffs occuring at low energies within the resonance energy range considered. These spectral features result from the anisotropic character of particle transport in the downstream magnetic field, where field compression produces effectively 2D perturbations. Because of the downstream field compression, the acceleration process is inefficient in parallel shocks for larger turbulence amplitudes, and features observed in oblique shocks are recovered. For small-amplitude turbulence, wide-energy range particle spectra are formed and modifications of the process due to the existence of long-wave perturbations are observed. In both sub- and superluminal shocks, an increase of \gamma leads to steeper spectra with lower cut-off energies. The spectra obtained for the ``realistic'' background conditions assumed here do not converge to the ``universal'' spectral index claimed in the literature. Thus the role of the first-order Fermi process in astrophysical sources hosting relativistic shocks requires serious reanalysis.Comment: submitted to Ap

Cosmic Ray Acceleration at Relativistic Shock Waves with a "Realistic" Magnetic Field Structure

The process of cosmic ray first-order Fermi acceleration at relativistic shock waves is studied with the method of Monte Carlo simulations. The simulations are based on numerical integration of particle equations of motion in a turbulent magnetic field near the shock. In comparison to earlier studies, a few "realistic" features of the magnetic field structure are included. The upstream field consists of a mean field component inclined at some angle to the shock normal with finite-amplitude sinusoidal perturbations imposed upon it. The perturbations are assumed to be static in the local plasma rest frame. Their flat or Kolmogorov spectra are constructed with randomly drawn wave vectors from a wide range $(k_{min}, k_{max})$. The downstream field structure is derived from the upstream one as compressed at the shock. We present particle spectra and angular distributions obtained at mildly relativistic sub- and superluminal shocks and also parallel shocks. We show that particle spectra diverge from a simple power-law, the exact shape of the spectrum depends on both the amplitude of the magnetic field perturbations and the wave power spectrum. Features such as spectrum hardening before the cut-off at oblique subluminal shocks and formation of power-law tails at superluminal ones are presented and discussed. At parallel shocks, the presence of finite-amplitude magnetic field perturbations leads to the formation of locally oblique field configurations at the shock and the respective magnetic field compressions. This results in the modification of the particle acceleration process, introducing some features present in oblique shocks, e.g., particle reflections from the shock. We demonstrate for parallel shocks a (nonmonotonic) variation of the particle spectral index with the turbulence amplitude.Comment: revised version (37 pages, 13 figures

Self-Similar Collisionless Shocks

Observations of gamma-ray burst afterglows suggest that the correlation length of magnetic field fluctuations downstream of relativistic non-magnetized collisionless shocks grows with distance from the shock to scales much larger than the plasma skin depth. We argue that this indicates that the plasma properties are described by a self-similar solution, and derive constraints on the scaling properties of the solution. For example, we find that the scaling of the characteristic magnetic field amplitude with distance from the shock is B \propto D^{s_B} with -1<s_B<=0, that the spectrum of accelerated particles is dn/dE \propto E^{-2/(s_B+1)}, and that the scaling of the magnetic correlation function is \propto x^{2s_B} (for x>>D). We show that the plasma may be approximated as a combination of two self-similar components: a kinetic component of energetic particles and an MHD-like component representing "thermal" particles. We argue that the latter may be considered as infinitely conducting, in which case s_B=0 and the scalings are completely determined (e.g. dn/dE \propto E^{-2} and B \propto D^0). Similar claims apply to non- relativistic shocks such as in supernova remnants, if the upstream magnetic field can be neglected. Self-similarity has important implications for any model of particle acceleration and/or field generation. For example, we show that the diffusion function in the angle \mu of momentum p in diffusive shock acceleration models must satisfy D_{\mu\mu}(p,D) = D^{-1}D'_{\mu\mu}(p/D), and that a previously suggested model for the generation of large scale magnetic fields through a hierarchical merger of current-filaments should be generalized. A numerical experiment testing our analysis is outlined (Abridged).Comment: 16 pages, 1 figure, accepted for publication in Ap

Analytical Study of Diffusive Relativistic Shock Acceleration

Particle acceleration in relativistic shocks is studied analytically in the test-particle, small-angle scattering limit, for an arbitrary velocity-angle diffusion function D. Accurate analytic expressions for the spectral index s are derived using few (2-6) low-order moments of the shock-frame angular distribution. For isotropic diffusion, previous results are reproduced and justified. For anisotropic diffusion, s is shown to be sensitive to D, particularly downstream and at certain angles, and a wide range of s values is attainable. The analysis, confirmed numerically, can be used to test collisionless shock models and to observationally constrain D. For example, strongly forward- or backward-enhanced diffusion downstream is ruled out by GRB afterglow observations.Comment: 4 pages, 2 figures, PRL accepted, minor change

Periodically Varying Externally Imposed Environmental Effects on Population Dynamics

Effects of externally imposed periodic changes in the environment on population dynamics are studied with the help of a simple model. The environmental changes are represented by the temporal and spatial dependence of the competition terms in a standard equation of evolution. Possible applications of the analysis are on the one hand to bacteria in Petri dishes and on the other to rodents in the context of the spread of the Hantavirus epidemic. The analysis shows that spatio-temporal structures emerge, with interesting features which depend on the interplay of separately controllable aspects of the externally imposed environmental changes.Comment: 7 pages, 8 figures, include

Program on Earth Observation Data Management Systems (EODMS)

An assessment was made of the needs of a group of potential users of satellite remotely sensed data (state, regional, and local agencies) involved in natural resources management in five states, and alternative data management systems to satisfy these needs are outlined. Tasks described include: (1) a comprehensive data needs analysis of state and local users; (2) the design of remote sensing-derivable information products that serve priority state and local data needs; (3) a cost and performance analysis of alternative processing centers for producing these products; (4) an assessment of the impacts of policy, regulation and government structure on implementing large-scale use of remote sensing technology in this community of users; and (5) the elaboration of alternative institutional arrangements for operational Earth Observation Data Management Systems (EODMS). It is concluded that an operational EODMS will be of most use to state, regional, and local agencies if it provides a full range of information services -- from raw data acquisition to interpretation and dissemination of final information products

Kernels for Grassmann flops

We develop a generalization of the $Q$-construction of the first author, Diemer, and the third author for Grassmann flips. This generalization provides a canonical idempotent kernel on the derived category of the associated global quotient stack. The idempotent kernel, after restriction, induces a semi-orthogonal decomposition which compares the flipped varieties. Furthermore its image, after restriction to the geometric invariant theory semistable locus, "opens" a canonical "window" in the derived category of the quotient stack. We check this window coincides with the set of representations used by Kapranov to form a full exceptional collection on Grassmannians