Technologies of transmission

Comment on Lemonnier, Pierre. 2012. Mundane objects: Materiality and non-verbal communication. Walnut Creek, CA: Left Coast Press

Predictors of Missed Hepatitis C Intake Appointments and Failure to Establish Hepatitis C Care Among Patients Living With HIV.

BackgroundWe estimated and characterized the proportion of patients living with HIV (PLWH) who missed hepatitis C (HCV) intake appointments and subsequently failed to establish HCV care.MethodsLogistic regression analyses were used to identify factors associated with missed HCV intake appointments and failure to establish HCV care among PLWH referred for HCV treatment between January 2014 and December 2017. In addition to demographics, variables included HIV treatment characteristics, type of insurance, liver health status, active alcohol or illicit drug use, unstable housing, and history of a mental health disorder (MHD).ResultsDuring the study period, 349 new HCV clinic appointments were scheduled for 202 unduplicated patients. Approximately half were nonwhite, and 80% had an undetectable HIV viral load. Drug use (31.7%), heavy alcohol use (32.8%), and MHD (37.8%) were prevalent. Over the 4-year period, 21.9% of PLWH referred for HCV treatment missed their HCV intake appointment. The proportion increased each year, from 17.2% in 2014 to 25.4% in 2017 (P = .021). Sixty-six of the 202 newly referred HCV patients (32.7%) missed their first HCV appointment, and 28 of these (42.4%) failed to establish HCV care. Having a history of MHD, CD4 <200, ongoing drug use, and being nonwhite were independent predictors of missing an intake HCV appointment. The strongest predictor of failure to establish HCV care was having a detectable HIV viral load.ConclusionsThe proportion of PLWH with missed HCV appointments increased over time. HCV elimination among PLWH may require integrated treatment of MHD and substance use

Selection of microbes for control of Rhizoctonia root rot on wheat using a high throughput pathosystem

© 2017 Elsevier. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:// creativecommons.org/licenses/by-nc-nd/4.0/ This author accepted manuscript is made available following 12 month embargo from date of publication (July 2017) in accordance with the publisher’s archiving policyThe promise of microbial biological control of soilborne fungal pathogens of crops has yet to be fully realised with only a few strains commercialised and available to growers. One bottleneck is the availability of suitable methods to screen microorganisms for disease control efficacy relevant to controlling disease in the field. A 3-phase in planta pathosystem containing field soil was developed to screen 2310 microorganisms for control of Rhizoctonia root rot on wheat. Test strains were added to seeds as a suspension at planting and plant growth assessed at two weeks. Strains increasing plant height and number of roots (185) were tested in a replicated Rhizoctonia pot bioassay with five wheat seedlings grown for four weeks and assessed for plant growth and root disease. Forty-three strains (1.9% of strains tested) performed better than our benchmark strains and were reassessed in pot bioassays at three inoculation levels. These tested strains represented a wide diversity of microbial genotypes including fungi, (Trichoderma, Aspergillus and Cylindrocarpon) and bacteria encompassing four phyla (Actinobacteria, Firmicutes, Proteobacteria, Bacteroidetes). These results show that microbes can be successfully and rapidly screened directly for disease control on plants

Field assessment of microbial inoculants to control Rhizoctonia root rot on wheat

© 2019 Elsevier Inc. This manuscript version is made available under the CC-BY-NC-ND 4.0 license: http://creativecommons.org/licenses/by-nc-nd/4.0/ This author accepted manuscript is made available following 12 month embargo from date of publication (February 2019) in accordance with the publisher’s archiving policyRhizoctonia root rot caused by Rhizoctonia solani AG8 is a major disease in dryland cereal crops. Previous research identified a suite of microbes using in planta bioassay screening that are effective as seed-coated inoculants for control of Rhizoctonia root rot on wheat. This paper assessed 23 strains in fields in Australia with a history of naturally occurring R. solani AG8. Due to the patchy nature of Rhizoctonia root rot in the field, a 2-phase split-plot field trial system was used to allow comparison for disease control efficacy in the same disease space. Seed applied strains were first assessed for their ability to reduce Rhizoctonia using ‘microplots’ which compare adjacent treated and untreated one metre rows. Up to 10% increases in plant growth and a 32% reduction in root disease was measured at eight weeks after sowing. Selected strains were then assessed in 20 m six row (3 + 3) split plots for their effects on early season wheat growth and root damage and for grain yield. A Paenibacillus and a Streptomyces strain were identified which were able to reduce root damage by 20% and 32% and increase grain yield by 4.2% and 2.8%, respectively, compared to untreated controls. The current best registered chemical control for Rhizoctonia root rot reduced root disease by 35% and increased yield by 3.0% in the same trial

Double Burden of Malnutrition Workshop Facilitation Manual: Lima, Peru

This is a facilitation manual for workshops in Lima, Peru as part of the project “Addressing the double burden of malnutrition in Peru: using a community-based system dynamics approach to improve food systems”. The project is a collaboration between investigators at the Center of Excellence in Chronic Diseases (CRONICAS) at the University of Peruana Cayetano Heredia, Universidad de los Andes in Bogota, Peru, the Social System Design Lab at Washington University in St. Louis, USA and Imperial College London funded by the Biotechnology and Biological Science Research Council (Grant Ref: BB/T009004/1). It is a supplemental document associated with the paper “Mapping food system drivers of the double burden of malnutrition using community-based system dynamics: a case study in Peru by Carmen Quinteros-Reyes, Paraskevi Seferidi, Laura Guzman-Abello, Christopher Millett, Antonio Bernabé-Ortiz, Ellis Ballard

Double Burden of Malnutrition Workshop Facilitation Manual: Iquitos, Peru

This is a facilitation manual for workshops in Lima, Peru as part of the project “Addressing the double burden of malnutrition in Peru: using a community-based system dynamics approach to improve food systems”. The project is a collaboration between investigators at the Center of Excellence in Chronic Diseases (CRONICAS) at the University of Peruana Cayetano Heredia, Universidad de los Andes in Bogota, Peru, the Social System Design Lab at Washington University in St. Louis, USA and Imperial College London funded by the Biotechnology and Biological Science Research Council (Grant Ref: BB/T009004/1). It is a supplemental document associated with the paper “Mapping food system drivers of the double burden of malnutrition using community-based system dynamics: a case study in Peru by Carmen Quinteros-Reyes, Paraskevi Seferidi, Laura Guzman-Abello, Christopher Millett, Antonio Bernabé-Ortiz, Ellis Ballard

Evidence for unusual spatial location coding in Williams syndrome: An explanation for the local bias in visuo-spatial construction tasks?

Individuals with Williams syndrome (WS) display poor visuo-spatial cognition relative to verbal abilities. Furthermore, whilst perceptual abilities are delayed, visuo-spatial construction abilities are comparatively even weaker, and are characterised by a local bias. We investigated whether this differentiation in visuo-spatial abilities can be explained by a deficit in coding spatial location in WS. This can be measured by assessing participants? understanding of the spatial relations between objects within a visual scene. Coordinate and categorical spatial relations were investigated independently in four participant groups: 21 individuals with WS; 21 typically developing (TD) children matched for non-verbal ability; 20 typically developing controls of a lower non-verbal ability; and 21 adults. A third task measured understanding of visual colour relations. Results indicated first, that the comprehension of categorical and co-ordinate spatial relations is equally poor in WS. Second, that the comprehension of visual relations is also at an equivalent level to spatial relational understanding in this population. These results can explain the difference in performance on visuo-spatial perception and construction tasks in WS. In addition, both the WS and control groups displayed response biases in the spatial tasks. However, the direction of bias differed across the groups. This finding is explored in relation to current theories of spatial location coding