1,601 research outputs found

    Viruses

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    Incompatible sets of gradients and metastability

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    We give a mathematical analysis of a concept of metastability induced by incompatibility. The physical setting is a single parent phase, just about to undergo transformation to a product phase of lower energy density. Under certain conditions of incompatibility of the energy wells of this energy density, we show that the parent phase is metastable in a strong sense, namely it is a local minimizer of the free energy in an L1L^1 neighbourhood of its deformation. The reason behind this result is that, due to the incompatibility of the energy wells, a small nucleus of the product phase is necessarily accompanied by a stressed transition layer whose energetic cost exceeds the energy lowering capacity of the nucleus. We define and characterize incompatible sets of matrices, in terms of which the transition layer estimate at the heart of the proof of metastability is expressed. Finally we discuss connections with experiment and place this concept of metastability in the wider context of recent theoretical and experimental research on metastability and hysteresis.Comment: Archive for Rational Mechanics and Analysis, to appea

    The CERN-Gran Sasso Neutrino Program

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    This paper reviews the current experimental program envisaged with the future CERN neutrino beam called CNGS. Two detectors, OPERA and ICARUS, are under preparation and should investigate the neutrino properties coming from the CNGS to shed light on neutrino oscillation physics.Comment: Invited talk at the Seventh International Workshop on Tau Lepton Physics (TAU02), Santa Cruz, CA, USA, Sept 2002, 9 pages, LaTex, 9 eps figures. PSN tau02_th09; v2: added 1 reference in section 6 + corrected typos and minor grammatical change

    Pacific Labour Mobility: Removing the Gender Blinkers

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    To date, women’s participation in the SWP and New Zealand’s Recognised Seasonal Employer (RSE) scheme has been low (Bailey 2014; Chattier 2015). Increasing women’s participation in these schemes is crucial if development gains are to be maximised. In this, the second in a series of In Briefs that consider women’s participation in the SWP, we examine what might be done to address the existing gender imbalances.AusAI

    Iridovirus from bees

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    An iridovirus, Apis iridescent virus (AIV), isolated from sick adult specimens of Apis cerana (Hymenoptera) from Kashmir, closely resembles iridescent viruses from Tipula and Sericesthis spp. (TIV and SIV). However, AIV is only distantly related serologically to TIV and SIV and is even moderately related to several other similar viruses that were tested in tube precipitation tests with intact particles. AIV multiplied in Apis mellifera, forming cytoplasmic iridescent crystalline aggregates in several tissues, but unlike all the other iridoviruses tested, it failed to multiply in Galleria mellonella

    Reproduction numbers for epidemic models with households and other social structures II: comparisons and implications for vaccination

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    In this paper we consider epidemic models of directly transmissible SIR (susceptible - infective - recovered) and SEIR (with an additional latent class) infections in fully-susceptible populations with a social structure, consisting either of households or of households and workplaces. We review most reproduction numbers defined in the literature for these models, including the basic reproduction number R0 introduced in the companion paper of this, for which we provide a simpler, more elegant derivation. Extending previous work, we provide a complete overview of the inequalities among these reproduction numbers and resolve some open questions. Special focus is put on the exponential-growth-associated reproduction number Rr, which is loosely defined as the estimate of R0 based on the observed exponential growth of an emerging epidemic obtained when the social structure is ignored. We show that for the vast majority of the models considered in the literature Rr >= R0 when R0 >=1 and Rr <= R0 when R0 <= 1. We show that, in contrast to models without social structure, vaccination of a fraction 1-1/R0 of the population, chosen uniformly at random, with a perfect vaccine is usually insufficient to prevent large epidemics. In addition, we provide significantly sharper bounds than the existing ones for bracketing the critical vaccination coverage between two analytically tractable quantities, which we illustrate by means of extensive numerical examples

    Trends in out-of-hospital cardiac arrest incidence, patient characteristics and survival over 18 years in Perth, Western Australia

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    Objectives: To investigate trends in the incidence, characteristics, and survival of out-of-hospital cardiac arrests (OHCA) in the Perth metropolitan area between 2001 and 2018. Methods: We calculated the crude incidence rate, age-standardised incidence rate (ASIR) and age- and sex-specific incidence rates (per 100,000 population) for OHCA of presumed cardiac aetiology. ASIRs were calculated using the direct method of standardisation using the 2001 Australian Population standard. Survival was assessed at return of spontaneous circulation at emergency department arrival and at 30 days. Temporal trends in patient and arrest characteristics were assessed with logistic regression, while trends in incidence were assessed using Joinpoint regression. Survival trends were assessed using binary logistic regression. Results: A total of 18,417 OHCAs of presumed cardiac aetiology were attended by emergency medical services in Perth between 2001 and 2018. Overall, there were no significant changes in the crude or ASIR of OHCA over the study period, although OHCA incidence in 15–39 year-old males increased by 12.5% annually between 2011 and 2018. Both bystander cardiopulmonary resuscitation and bystander defibrillation increased over the study period, while the proportion of shockable arrests declined. Thirty-day OHCA survival improved significantly over time, with the odds of survival (in bystander-witnessed, initial shockable rhythm arrests) improving 12% (95% CI, 9.0% to 14.0%) annually, from 8.4% in 2001 to 44.0% in 2018. Conclusion: Overall, there were no significant trends in OHCA incidence over the study period, although arrests in 15–39 year-old males increased significantly after 2011. There were significant improvements in 30-day survival between 2001 and 2018

    Determination of the stretch tensor for structural transformations

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    The transformation stretch tensor plays an essential role in the evaluation of conditions of compatibility between phases and the use of the Cauchy-Born rule. This tensor is difficult to measure directly from experiment. We give an algorithm for the determination of the transformation stretch tensor from x-ray measurements of structure and lattice parameters. When evaluated on some traditional and emerging phase transformations the algorithm gives unexpected results.Comment: 3 figures, 1 tabl
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