375 research outputs found
Optical imaging and pH-awakening therapy of deep tissue cancer based on specific upconversion nanophotosensitizers
Robotic treatment of colorectal endometriosis: technique, feasibility and short-term results
background: Deep infiltrating endometriosis (DIE) is a complex disease that impairs the quality of life and the fertility of women. Since
a medical approach is often insufficient, a minimally invasive approach is considered the gold standard for complete disease excision. Roboticassisted
surgery is a revolutionary approach, with several advantages compared with traditional laparoscopic surgery.
methods: From March 2010 to May 2011, we performed 22 consecutive robotic-assisted complete laparoscopic excisions of DIE endometriosis
with colorectal involvement. All clinical data were collected by our team and all patients were interviewed preoperatively and 3 and
6 months post-operatively and yearly thereafter regarding endometriosis-related symptoms. Dysmenorrhoea, dyschezia, dyspareunia and
dysuria were evaluated with a 10-point analog rating scale.
results: There were 12 patients, with a median larger endometriotic nodule of 35 mm, who underwent segmental resection, and 10
patients, with a median larger endometriotic nodule of 30 mm, who underwent complete nodule debulking by colorectal wall-shaving technique.
No laparotomic conversions were performed, nor was any blood transfusion necessary. No intra-operative complications were
observed and, in particular, there were no inadvertent rectal perforations in any of the cases treated by the shaving technique. None of
the patients had ileostomy or colostomy. No major post-operative complications were observed, except one small bowel occlusion 14
days post-surgery that was resolved in 3 days with medical treatment. Post-operatively, a statistically significant improvement of patient symptoms
was shown for all the investigated parameters.
conclusions: To our knowledge, this is the first study reporting the feasibility and short-term results and complications of laparoscopic
robotic-assisted treatment of DIE with colorectal involvement.We demonstrate that this approach is feasible and safe, without conversion to
laparotomy
Extensive solitary lymphatic malformation of the liver in a child: a case report and literature review
Intrabdominal lymphatic malformations are rare benign congenital vascular anomalies that account for less than 5% of benign masses in childhood, with an extremely variable clinical presentation. For this reason, although their radiological appearance is usually typical, diagnosis can be challenging and not always immediate. This report describes a unique case of extensive solitary hepatic lymphatic malformation in a 10-year-old boy with both extra- and intraparenchymal development with no associated symptoms. A literature review of reported cases of solitary hepatic lymphatic malformation is also included
The X-Gamma Imaging Spectrometer (XGIS) onboard THESEUS
A compact and modular X and gamma-ray imaging spectrometer (XGIS) has been
designed as one of the instruments foreseen on-board the THESEUS mission
proposed in response to the ESA M5 call. The experiment envisages the use of
CsI scintillator bars read out at both ends by single-cell 25 mm 2 Silicon
Drift Detectors. Events absorbed in the Silicon layer (lower energy X rays) and
events absorbed in the scintillator crystal (higher energy X rays and
Gamma-rays) are discriminated using the on-board electronics. A coded mask
provides imaging capabilities at low energies, thus allowing a compact and
sensitive instrument in a wide energy band (~2 keV up to ~20 MeV). The
instrument design, expected performance and the characterization performed on a
series of laboratory prototypes are discussed.Comment: To be published in the Proceedings of the THESEUS Workshop 2017
(http://www.isdc.unige.ch/theseus/workshop2017.html), Journal of the Italian
Astronomical Society (Mem.SAIt), Editors L. Amati, E. Bozzo, M. Della Valle,
D. Gotz, P. O'Brien. Details on the THESEUS mission concept can be found in
the white paper Amati et al. 2017 (arXiv:171004638) and Stratta et al. 2017
(arXiv:1712.08153
Parylene C-based, breathable tattoo electrode for high-quality biopotential measurements
A breathable tattoo electrode for bio-potential recording based on a Parylene C nanofilm is presented in this study. The proposed approach allows for the fabrication of micro-perforated epidermal submicrometer-thick electrodes that conjugate the unobtrusiveness of Parylene C nanofilms and the very important feature of breathability. The electrodes were fully validated for electrocardiography (ECG) measurements showing performance comparable to that of conventional disposable gelled Ag/AgCl electrodes, with no visible negative effect on the skin even many hours after their application. This result introduces interesting perspectives in the field of epidermal electronics, particularly in applications where critical on-body measurements are involved
Ceramide and palmitic acid inhibit macrophage-mediated epithelial-mesenchymal transition in colorectal cancer
Accumulating evidence indicates that ceramide (Cer) and palmitic acid (PA) possess the ability to modulate switching of macrophage phenotypes and possess anti-tumorigenic effects; however, the underlying molecular mechanisms are largely unknown. The aim of the present study was to investigate whether Cer and PA could induce switching of macrophage polarization from the tumorigenic M2- towards the pro-inflammatory M1-phenotype, and whether this consequently altered the potential of colorectal cancer cells to undergo epithelial-mesenchymal transition (EMT), a hallmark of tumor progression. Our study showed that Cer- and PA-treated macrophages increased expression of the macrophage 1 (M1)-marker CD68 and secretion of IL-12 and attenuated expression of the macrophage 2 (M2)-marker CD163 and IL-10 secretion. Moreover, Cer and PA abolished M2 macrophage-induced EMT and migration of colorectal cancer cells. At the molecular level, this coincided with inhibition of SNAI1 and vimentin expression and upregulation of E-cadherin. Furthermore, Cer and PA attenuated expression levels of IL-10 in colorectal cancer cells co-cultured with M2 macrophages and downregulated STAT3 and NF-kappa B expression. For the first time, our findings suggest the presence of an IL-10-STAT3-NF-kappa B signaling axis in colorectal cancer cells co-cultured with M2 macrophages, mimicking the tumor microenvironment. Importantly, PA and Cer were powerful inhibitors of this signaling axis and, consequently, EMT of colorectal cancer cells. These results contribute to our understanding of the immunological mechanisms that underlie the anti-tumorigenic effects of lipids for future combination with drugs in the therapy of colorectal carcinoma.Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas
Ceramide and palmitic acid inhibit macrophage-mediated epithelial-mesenchymal transition in colorectal cancer (vol 468, pg 153, 2020)
Imaging- and therapeutic targets in neoplastic and musculoskeletal inflammatory diseas
LOFT - a Large Observatory For x-ray Timing
The high time resolution observations of the X-ray sky hold the key to a
number of diagnostics of fundamental physics, some of which are unaccessible to
other types of investigations, such as those based on imaging and spectroscopy.
Revealing strong gravitational field effects, measuring the mass and spin of
black holes and the equation of state of ultradense matter are among the goals
of such observations. At present prospects for future, non-focused X-ray timing
experiments following the exciting age of RXTE/PCA are uncertain. Technological
limitations are unavoidably faced in the conception and development of
experiments with effective area of several square meters, as needed in order to
meet the scientific requirements. We are developing large-area monolithic
Silicon Drift Detectors offering high time and energy resolution at room
temperature, which require modest resources and operation complexity (e.g.,
read-out) per unit area. Based on the properties of the detector and read-out
electronics that we measured in the lab, we developed a realistic concept for a
very large effective area mission devoted to X-ray timing in the 2-30 keV
energy range. We show that effective areas in the range of 10-15 square meters
are within reach, by using a conventional spacecraft platform and launcher of
the small-medium class.Comment: 13 pages, 8 figures, 1 table, Proceedings of SPIE Vol. 7732, Paper
No. 7732-66, 201
Steps towards the hyperfine splitting measurement of the muonic hydrogen ground state: pulsed muon beam and detection system characterization
The high precision measurement of the hyperfine splitting of the
muonic-hydrogen atom ground state with pulsed and intense muon beam requires
careful technological choices both in the construction of a gas target and of
the detectors. In June 2014, the pressurized gas target of the FAMU experiment
was exposed to the low energy pulsed muon beam at the RIKEN RAL muon facility.
The objectives of the test were the characterization of the target, the
hodoscope and the X-ray detectors. The apparatus consisted of a beam hodoscope
and X-rays detectors made with high purity Germanium and Lanthanum Bromide
crystals. In this paper the experimental setup is described and the results of
the detector characterization are presented.Comment: 22 pages, 14 figures, published and open access on JINS
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