Plasma Concentrations of Tranexamic Acid in Postpartum Women After Oral Administration.

OBJECTIVE: To evaluate the pharmacokinetics of tranexamic acid after oral administration to postpartum women. METHODS: We conducted a single-center pharmacokinetic study at Teaching Hospital-Jaffna, Sri Lanka, on 12 healthy postpartum women who delivered vaginally. After oral administration of 2 g of immediate-release tranexamic acid 1 hour after delivery, pharmacokinetic parameters were measured on plasma samples at 0, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 5, 6, 8, 10, and 12 hours. Plasma tranexamic acid concentrations were determined by high-performance liquid chromatography. The outcome measures were maximum observed plasma concentration, time to maximum plasma concentration, time to reach effective plasma concentration, time period effective serum concentration lasted, area under the curve for drug concentration, and half-life of tranexamic acid. RESULTS: The mean maximum observed plasma concentration was 10.06 micrograms/mL (range 8.56-12.22 micrograms/mL). The mean time to maximum plasma concentration was 2.92 hours (range 2.5-3.5 hours). Mean time taken to reach the effective plasma concentration of 5 micrograms/mL and the mean time this concentration lasted were 0.87 hours and 6.73 hours, respectively. Duration for which plasma tranexamic acid concentration remained greater than 5 micrograms/mL was 5.86 hours. Half-life was 1.65 hours. Area under the curve for drug concentration was 49.16 micrograms.h/mL (range 43.75-52.69 micrograms.h/mL). CONCLUSION: Clinically effective plasma concentrations of tranexamic acid in postpartum women may be achieved within 1 hour of oral administration. Given the promising pharmacokinetic properties, we recommend additional studies with larger sample sizes to investigate the potential of oral tranexamic acid for the treatment or prophylaxis of postpartum hemorrhage

चेन्नई मात्स्यिकी पोताश्रय में बैग जाल द्वारा बोई (मल्लेट) मुजिल सेफेलस का भारी अवतरण

कृपया पूरा लेखा पढ

Some recent observations on small-scale fishery In the vicinity of Madras

Madras zone is one of the important fishing centres on the east coast of India. To understand the fish landings from different gears in Madras, three landing centres, viz., Kasimedu, Triplicane and Nochikuppam were selected. Kasimedu is about 8 km north of Triplicane and Nochikuppam is about 2 km south of Triplicane. The major catch components from the demersal trawls of this area arc silver bellies, threadfin breams, sciaenids, lizardfish, prawns, squids and cuttlefish. These groups are landed in a meagre quantity by the traditional gears, thus maintaining compatability between mechanised and non-mechanised gears in the exploitation of fishery resources off Madras

रजत कोंगर सर्पमीन के वायूआशय का चेन्नई से निर्यात

कृपया पूरा लेखा पढ

A Research on Wireless Power Transmission using Distinguished Methodologies

Flat screen TV’s and picture frames that suspend on the wall-without needing a cable and plug up for power. Industrial structures and medical machines can be made more trustworthy by eradicating difficulty prone wiring and disposable batteries. The method takes the advantage of straightforward physics and could be used to indict a variety of electronic tools over numerous meters. The arrangement could substitute the miles of costly power cables and billions of throw-away batteries. There is rather like 40 billion throw-away batteries built each year for power that is employed within a petite inches or feet of where there is extremely low-cost power. If this knowledge is acknowledged in prospect it will make daily products additional expedient, consistent, and environmentally welcoming. This document includes the methods of transmitting power with no usage of wires with improved efficiency, due to which it does not influence the atmospheric surrounding

On the Effect of Rigid Swept Surface Waves on Turbulent Drag

Passive turbulent drag reduction techniques are of interest as a cost effective means to improve air vehicle fuel consumption. In the past, rigid surface waves slanted at an angle from the streamwise direction were deemed ineffective to reduce skin friction drag due to the pressure drag that they generate. A recent analysis seeking similarities to the spanwise shear stress generated by spatial Stokes layers suggested that there may be a range of wavelength, amplitude, and orientation in which the wavy surface would reduce turbulent drag. The present work explores, by experiments and Direct Numerical Simulations (DNS), the effect of swept wavy surfaces on skin friction and pressure drag. Plates with shallow and deep wave patterns were rapid-prototyped and tested using a drag balance in the 7x11 inch Low-Speed Wind Tunnel at the NASA LaRC Research Center. The measured drag o set between the wavy plates and the reference at plate is found to be within the experimental repeatability limit. Oil vapor flow measurements indicate a mean spanwise flow over the deep waves. The turbulent flow in channels with at walls, swept wavy walls and spatial Stokes spanwise velocity forcing was simulated at a friction Reynolds number of two hundred. The time-averaged and dynamic turbulent flow characteristics of the three channel types are compared. The drag obtained for the channel with shallow waves is slightly larger than for the at channel, within the range of the experiments. In the case of the large waves, the simulation over predicts the drag. The shortcomings of the Stokes layer analogy model for the estimation of the spanwise shear stress and drag are discussed

Bio-Medical Application of Wireless Power Transmission System

This paper presents the wireless power transmission system is separated into three main components, the transceiver, the inductive coils and the RF/DC converter. Simple examines were done to check the model and simulations were done to display the benefit of wireless power transmission which also avoids accidents related to large wires and no adequate grounding. To increase the quality of diagnosis, some main specifications such as image resolution, frame rate and working time need to be developed. Moreover, future multi-functioning robotic capsule endoscopy units may consume advanced features such as energetic system control over capsule motion, drug delivery systems, semi-surgical tools and biopsy. However, the addition of the above innovative features demands extrapower that makes conventional power source methods are difficult. In this regards, wireless power transmission system has received attention among researchers to overcome this problem. This paper defines the reviews on techniques of using wireless power transmission for bio-medical applications

'Thoorivala' and its multi use

Thoorivalai' seems to be profitable as the man power used is less and catch landed is high. They get a large quantity of fish with a minimum of 600 kg to a maximum of 800 kg. The fishermen using this type of fishing at Kadathukkuppam (Tanjore Dt.) got a maximum of 700 kg fish by putting 9 hauls and engaging 10 persons a unit during July, 1988

A simple procedure for hydroboration using tetrabutylammonium borohydride

1189-119

Heavy landing of Upeneus taeniopterus along Chennai coast

During the period from 20-06-2005 to 28- 06-2005, there was unusually heavy landing of goatfish by trawlers at Chennai Fisheries Harbour. In June 2005 alone 388 tonnes of goatfish were landed from depths of 60-80m with a catch rate of 5.4 kg per hour