Plastic Surgery After Gastric Bypass Improves Long-Term Quality of Life

Background: Excess skin after massive weight loss impairs patient's health-related quality of life (HRQoL). Therefore, body-contouring surgeries can be proposed. However, few data exist concerning the effect of body contouring after bariatric surgery on HRQoL, including control group with a long-term follow-up. Methods: In a prospective study, 98 consecutive patients who had body contouring after gastric bypass for obesity (BMI > 40) were included (group A). A matched control-group containing 102 patients who had only gastric bypass was selected (group B). HRQoL was measured by Moorehead-Ardelt questionnaire before (group A1) and after (A2) body contouring, and at different time points for group B until 8years post-gastric bypass. To evaluate the effect of body contouring by two parallel methods, HRQoL was compared between groups A1 and A2, and between A2 and B. Results: We found that body contouring procedures improved significantly patients' HRQoL, in comparison to those who had only gastric bypass. Of the patients who had body contouring (group A2), 57% evaluated their HRQoL "much better” in comparison to only 22% of patients before body contouring (group A1) or those who never had body contouring (group B) (p < 0.001). The improvement was significant in all sub-domains of HRQoL: self-esteem, social life, work ability, sexual activity and physical activity (p < 0.001), and remained stable over time. Conclusions: Our study confirms the important role of plastic surgery in treatment of patients after massive weight loss. We demonstrated that body contouring, despite important scars, significantly improves satisfaction and HRQoL of patients after gastric bypass. Therefore, the treatment of morbid obesity should not be deemed achieved unless plastic surgery has been considere

Intravascular Large B-Cell Lymphoma Genomic Profile Is Characterized by Alterations in Genes Regulating NF-κB and Immune Checkpoints.

Intravascular large B-cell lymphoma (IVLBCL) is an uncommon lymphoma with an aggressive clinical course characterized by selective growth of tumor cells within the vessels. Its pathogenesis is still uncertain and there is little information on the underlying genomic alterations. In this study, we performed a clinicopathologic and next-generation sequencing analysis of 15 cases of IVLBCL using a custom panel for the detection of alterations in 68 recurrently mutated genes in B-cell lymphomagenesis. Six patients had evidence of hemophagocytic syndrome. Four patients presented concomitantly a solid malignancy. Tumor cells outside the vessels were observed in 7 cases, 2 with an overt diffuse large B-cell cell lymphoma. In 4 samples, tumor cells infiltrated lymphatic vessel in addition to blood capillaries. Programmed death-ligand 1 (PD-L1) was positive in tumor cells in 4 of 11 evaluable samples and in macrophages intermingled with tumor cells in 8. PD-L1 copy number gains were identified in a higher proportion of cases expressing PD-L1 than in negative tumors. The most frequently mutated gene was PIM1 (9/15, 60%), followed by MYD88L265P and CD79B (8/15, 53% each). In 6 cases, MYD88L265P and CD79B mutations were detected concomitantly. We also identified recurrent mutations in IRF4 , TMEM30A , BTG2 , and ETV6 loci (4/15, 27% each) and novel driver mutations in NOTCH2 , CCND3 , and GNA13 , and an IRF4 translocation in 1 case each. The mutational profile was similar in patients with and without evidence of hemophagocytic syndrome and in cases with or without dissemination of tumor cells outside the vessels. Our results confirm the relevance of mutations in B-cell receptor/nuclear factor-κB signaling and immune escape pathways in IVLBCL and identify novel driver alterations. The similar mutational profile in tumors with extravascular dissemination suggests that these cases may also be considered in the spectrum of IVLBCL

Propuesta para la valoración del rol de los microorganismos del suelo en sistemas agrícolas sustentables: aplicación en el ámbito de la Escuela Agropecuaria Nº 1 de Berisso

La transferencia del conocimiento científico hacia el sector productivo es clave para incrementar la producción sustentable. Un caso modelo es el uso adecuado de los recursos, en particular, valorar el rol de los microorganismos del suelo y concientizar a los actores de la producción. Con este fin docentes del Curso de Microbiología Agrícola de la Fac. de Cs. Agrarias y Forestales de la UNLP generaron una actividad que estuvo dirigida a estudiantes secundarios de escuelas agropecuarias y se aplicó en la Escuela Agropecuaria Nº 1 de Berisso. Los participantes tomaron conciencia sobre la importancia de los microorganismos en el suelo y el rol que juegan en la conservación de este recurso, lo que en definitiva conduce a un manejo sustentable. Estos resultados sugieren que la actividad se debe extender a otros centros educativos agrotécnicos y también a los productores de la región productiva del Gran La Plata, de manera de fortalecer el concepto que cumplen los microorganismos en la producción y sostenibilidad de los sistemas agrícolas.Eje: B5 Sistemas de conocimiento (Relatos de experiencias)Facultad de Ciencias Agrarias y Forestale

Propuesta para la valoración del rol de los microorganismos del suelo en sistemas agrícolas sustentables: aplicación en el ámbito de la Escuela Agropecuaria Nº 1 de Berisso

La transferencia del conocimiento científico hacia el sector productivo es clave para incrementar la producción sustentable. Un caso modelo es el uso adecuado de los recursos, en particular, valorar el rol de los microorganismos del suelo y concientizar a los actores de la producción. Con este fin docentes del Curso de Microbiología Agrícola de la Fac. de Cs. Agrarias y Forestales de la UNLP generaron una actividad que estuvo dirigida a estudiantes secundarios de escuelas agropecuarias y se aplicó en la Escuela Agropecuaria Nº 1 de Berisso. Los participantes tomaron conciencia sobre la importancia de los microorganismos en el suelo y el rol que juegan en la conservación de este recurso, lo que en definitiva conduce a un manejo sustentable. Estos resultados sugieren que la actividad se debe extender a otros centros educativos agrotécnicos y también a los productores de la región productiva del Gran La Plata, de manera de fortalecer el concepto que cumplen los microorganismos en la producción y sostenibilidad de los sistemas agrícolas.Eje: B5 Sistemas de conocimiento (Relatos de experiencias)Facultad de Ciencias Agrarias y Forestale

Propuesta para la valoración del rol de los microorganismos del suelo en sistemas agrícolas sustentables: aplicación en el ámbito de la Escuela Agropecuaria Nº 1 de Berisso

La transferencia del conocimiento científico hacia el sector productivo es clave para incrementar la producción sustentable. Un caso modelo es el uso adecuado de los recursos, en particular, valorar el rol de los microorganismos del suelo y concientizar a los actores de la producción. Con este fin docentes del Curso de Microbiología Agrícola de la Fac. de Cs. Agrarias y Forestales de la UNLP generaron una actividad que estuvo dirigida a estudiantes secundarios de escuelas agropecuarias y se aplicó en la Escuela Agropecuaria Nº 1 de Berisso. Los participantes tomaron conciencia sobre la importancia de los microorganismos en el suelo y el rol que juegan en la conservación de este recurso, lo que en definitiva conduce a un manejo sustentable. Estos resultados sugieren que la actividad se debe extender a otros centros educativos agrotécnicos y también a los productores de la región productiva del Gran La Plata, de manera de fortalecer el concepto que cumplen los microorganismos en la producción y sostenibilidad de los sistemas agrícolas.Eje: B5 Sistemas de conocimiento (Relatos de experiencias)Facultad de Ciencias Agrarias y Forestale

Selección de “indicadores microbiológicos de calidad del suelo” como tópico generativo para la enseñanza de Microbiología Agrícola en la FCAyF

Se presenta una innovación en el área de Microbiología Agrícola de las Carreras de Ingeniería Agronómica y Forestal, propiciando el “uso de indicadores microbiológicos de calidad del suelo” como “tópico generativo” en el marco de “la enseñanza para la comprensión”. Con la aplicación de esta metodología, se busca concientizar a los alumnos sobre la importancia de la conservación del recurso suelo y su biodiversidad, así como ponerlos en contacto con problemáticas hipotéticas de su futura actividad laboral. Se definieron las Metas de Comprensión, seleccionando los indicadores microbiológicos: determinación del recuento de flora total y grupos funcionales (celulolíticos, amonificadores, nitrificadores), actividad global del suelo empleando técnicas como la evaluación de la respiración y la deshidrogenasa. En base a los datos analizados se observa que la selección de este tópico generativo resultó adecuada para el desarrollo e integración de los contenidos del curso y permitió fomentar en los alumnos una actitud participativa en el proceso de enseñanza-aprendizaje.Eje temático 2: Los cambios e innovaciones en los procesos de formación\na - Alternativas didácticas y experiencias de renovación de la enseñanz

Risk factors for development of non-specific musculoskeletal pain in preteens and early adolescents: a prospective 1-year follow-up study

Background Musculoskeletal pain symptoms are common in children and adolescents. These symptoms have a negative impact on children's physical and emotional well-being, but their underlying aetiology and risk factors are still poorly understood. Most of the previous cohort studies were conducted among mid and/or late adolescents and were mainly focused on a specific pain location (e.g. low back pain or neck pain). The purpose of this study is to estimate occurrence of new-onset pain symptoms, in all musculoskeletal locations, in preteens and early adolescents and investigate risk factors for development of these symptoms. Methods 1756 schoolchildren (mean age 10.8) were recruited from schools in southern Finland. Information was extracted as to whether they experienced musculoskeletal pain and a total of 1192 children were identified as free of musculoskeletal pain symptoms. Information was collected on factors which could potentially predict the development of musculoskeletal pain: headache, abdominal pain, sadness/feeling down, day-time tiredness, difficulty in falling asleep, waking up during nights, level of physical activity and hypermobility. These children were followed-up 1-year later and those with new episodes of non-traumatic and traumatic musculoskeletal pain symptoms were identified. Results A total of 1113 schoolchildren (93% of baseline pain-free children) were found at one-year follow-up. New episodes of musculoskeletal pain were reported by 21.5% of these children. Of them 19.4% reported non-traumatic pain and 4.0% reported traumatic pain. The neck was the most commonly reported site with non-traumatic pain, while the lower limb was the most common site for traumatic pain. The independent risk factors for non-traumatic musculoskeletal pain were headache (OR = 1.68, [95% CI 1.16–2.44]) and day-time tiredness (OR = 1.53, [95% CI 1.03–2.26]). The risk factors for traumatic musculoskeletal pain were vigorous exercise (OR = 3.40 [95% CI 1.39–8.31]) and day-time tiredness (OR = 2.97 [95% CI 1.41–6.26]). Conclusion This study highlights that there may be two types of pain entities with both distinct and common aspects of aetiology. For primary prevention purposes, school healthcare professionals should pay attention to preteens and early adolescents practicing vigorous exercise (predictor of traumatic pain), reporting headache (predictor of non-traumatic pain) and reporting day-time tiredness (predictor of both types of pain).BioMed Central Open acces

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality