1,114 research outputs found
Clustering of fermionic truncated expectation values via functional integration
I give a simple proof that the correlation functions of many-fermion systems
have a convergent functional Grassmann integral representation, and use this
representation to show that the cumulants of fermionic quantum statistical
mechanics satisfy l^1-clustering estimates
Leukocyte Profile of Blood of Cows at Using “Leucozav” Against Leucosis of Cattle
The development of specific medical forms for fighting against the tumor disease (cancer) of people and animals has the extremely important value. The preparation «ZG-2011» («Leucozav») was invented in 2000-2006 by research associates of SSI “State center of innovative biotechnologies” that forms in inoculated animals the specific anti-viral immunity that protects cattle from being infected by the leucosis causative agent. Analogues of this preparation in Ukraine are absent. The main aim of the study is the determination of “Leucozav” influence on morphologic parameters of blood (leukocyte profile) of clinically healthy cows and ones, infected by leucosis.The object of the study was blood of cattle (milk herd), considered as unfavorable as to leucosis.Blood samples were studied before administering “Leucozav” and after that. Serological and immunological research methods were used.At the experiment it was studied, that «Leucozav» administration to infected animals normalizes leukocytes number and the ratio of their separate forms in blood of cows. In blood samples, taken of healthy cows, the preparation administration doesn\u27t influence the leukocyte profile.This experiment gives grounds to recommend the newly created preparation«Leucozav» to cows with leucosis, because it normalizes the number of leukocytes and their ration in separate forms in blood of RID-positive cows that react positively at the immune diffusion reaction in the agar gel at the study of leucosis of cattle
Distribution of 5-HT1F Receptors in Monkey Vestibular and Trigeminal Ganglion Cells
Background: Evidence of serotonergic involvement in vestibular pathway contributions to migraine and balance disorders is compelling. Serotonergic 5-HT1B and 5-HT1D receptors are expressed extensively in inner ear ganglia of monkeys and rats. The serotonergic 5-HT1F receptor is also a target of triptans. This study describes its distribution in vestibular and trigeminal ganglia of monkeys. Methods: Using primary polyclonal antibodies raised against oligopeptides specific for the human 5-HT1F receptor, neuronal somatic area and intensity of immunoreactive vestibular and trigeminal ganglia were quantified. Results and Discussion: Virtually all vestibular and considerable trigeminal ganglia showed positive 5-HT1F receptor immunoreactivity. Inferior and superior vestibular ganglia staining appeared confined to distinct cell regions, varying considerably among cells of different sizes: more intense in small, punctate in some medium and regionally polarized in some large cells. Analyses of average somatic vestibular neuronal immunoreactive intensity identified mainly medium sized cells with high standard deviation of intensity corresponding to punctately-stained cells. Less variability occurred in somatic intensity staining and cellular distribution among 5-HT1F receptor immunopositive trigeminal ganglia. Most exhibited similar punctate staining patterns, higher mean somatic immunoreactive intensity and larger neuronal somatic size proportions per size distribution subpopulation compared to vestibular ganglia size distribution populations. Centrally directed vestibular ganglion neuronal processes, cochlear inner hair cells, vestibular hair cells and blood vessels in vestibular maculae and cristae were immunoreactive. The 5-HT1F receptor expression in vestibular ganglia shows complex variable staining intensity patterns associated with cell size of immunopositive neurons, not seen in immunopositive trigeminal ganglia and not previously evident with 5-HT1B and 5-HT1D receptor subtype immunoreactivity in vestibular ganglia. These data motivate exploration of 5-HT1 receptor oligomerization and ligand functional selectivity in differential serotonergic involvement in co-morbidity of migraine and balance disorders. Similar findings in cochlear inner hair cell afferents are applicable to migraine related tinnitus or hypercusis (phonophobia)
Can adding Ephedrine to Admixture of Propofol & Lidocaine Overcome Propofol Associated Hemodynamic Changes and Injection Pain?
Purpose: There are numerous studies researching ways to alleviate propofol injection pain. In this study, we evaluated and compared the use of propofol-lidocaine admixture vs propofol-lidocaine combined with ephedrine, on vascular pain and hemodynamic changes associated propofol. Methods: This double-blinded, prospective, randomised study was performed on 100 patients with ASA I-II who were divided into two group. The first received admixture consisting of 20 mg of lidocaine and propofol 1% 20 ml (Group L), and the other received admixture consisting of 20 mcg ephedrine, 20 mg lidocaine and propofol 1% 20 ml (Group LE). Baseline and after induction heart rate, mean arterial pressure and rate pressure product (RPP) were recorded per minute. Vascular pain were evaluated with verbal rating scale. Results: Data of 40 patients in group L and 39 patients in Group LE were evaluated in the study. The incidence of pain in group L was 90%, it was 38.4% for Group LE. Mild pain was observed significantly more in Group L when compared to Group LE (p<0.05). Average blood pressure and RPP immediately after induction and 1 min after intubation were significantly higher in group LE compared to group L (p<0.05). Heart rate was higher in Group LE immediately after induction and at initially 4 minutes after intubation. Conclusion: Our study has demonstrated significant decrease in rate of vascular pain and increased hemodynamic stability in patients receiving 20 mg ephedrine added to 20 ml % 1 propofol and 20 mg lidocaine admixture when compared to those who only received the lidocaine-propofol admixtur
Measurement and prediction of CO2 solubility in sodium phosphate monobasic solutions for food treatment with high pressure carbon dioxide
Two experimental systems were designed and tested to measure the CO2 solubility in sodium dibasic phosphate solutions (0.276, 2.76 and 5.52 g/100 g water) at different pressures (7.5 and 15.0 MPa) and temperatures (35, 40 and 50°C). The results were compared with those for pure water.
Three thermodynamic solubility models were tested using the Aspen Simulation PlusTM software: 1) Peng-Robinson equation of state (EOS), where the a and b parameters were evaluated with the Wong and Sandler mixing rules (PRWS) and the activity coefficients were defined using the functional groups with the modified UNIFAC method 2) Electrolytic non-random two liquids (ELECNRTL) with the Redlich-Kwong equation of state for aqueous and mixed solvent applications 3) The completely predictive Soave-Redlich-Kwong (PSRK) equation of state.
CO2 solubility was a strong function of sodium dibasic phosphate concentrations. The predictions of the PRWS EOS agreed well with the experimental data in the pressure and temperature ranges tested. A higher difference between the experimental and predicted results was observed for conditions close to the CO2 critical point and for low sodium dibasic phosphate concentrations. Thermodynamic models 2 and 3 predictions had a much higher deviations from experimental data
Kinetics of flavour and aroma changes in thermally processed cupuaçu (Theobroma grandiflorum) pulp
Changes in `fresh' and `cooked-notes' during thermal treatment of cupuacËu (Theobroma
grandi¯orum) pulp were evaluated and modelled. Isothermal experiments in the temperature range of
70±98°C were carried out and a non-linear regression was performed to all data to estimate kinetic
parameters. `Fresh' and `cooked-notes' change followed simple ®rst-order (Ea=78±82kJ mol
ÿ1,
z =30±31°C) and reversible ®rst order (Ea=80±85kJ mol
ÿ1) kinetics, respectively. Although `cookednotes'
were linearly correlated with `fresh-notes' (R2=0.99), the former was a better indicator for
quality degradation. These results are useful to design pasteurisation processes while minimising
sensory changes
Strong, Ultra-narrow Peaks of Longitudinal and Hall Resistances in the Regime of Breakdown of the Quantum Hall Effect
With unusually slow and high-resolution sweeps of magnetic field, strong,
ultra-narrow (width down to ) resistance peaks are observed in
the regime of breakdown of the quantum Hall effect. The peaks are dependent on
the directions and even the history of magnetic field sweeps, indicating the
involvement of a very slow physical process. Such a process and the sharp peaks
are, however, not predicted by existing theories. We also find a clear
connection between the resistance peaks and nuclear spin polarization.Comment: 5 pages with 3 figures. To appear in PR
Random-phase Approximation Treatment Of Edge Magnetoplasmons: Edge-state Screening And Nonlocality
A random-phase approximation (RPA) treatment of edge magnetoplasmons (EMP) is
presented for strong magnetic fields, low temperatures, and integer filling
factors \nu. It is valid for negligible dissipation and lateral confining
potentials smooth on the scale of the magnetic length \ell_{0} but sufficiently
steep that the Landau-level (LL) flattening can be neglected. LL coupling,
screening by edge states, and nonlocal contributions to the current density are
taken into account. In addition to the fundamental mode with typical dispersion
relation \omega\sim q_x \ln(q_{x}), fundamental modes with {\it acoustic}
dispersion relation \omega\sim q_x are obtained for \nu>2. For \nu=1,2 a {\bf
dipole} mode exists, with dispersion relation \omega\sim q_x^3, that is
directly related to nonlocal responses.Comment: Text 12 pages in Latex/Revtex format, 4 Postscript figure
Efficacy of N-acetyl cysteine in traumatic brain injury
In this study, using two different injury models in two different species, we found that early post-injury treatment with NAcetyl Cysteine (NAC) reversed the behavioral deficits associated with the TBI. These data suggest generalization of a protocol similar to our recent clinical trial with NAC in blast-induced mTBI in a battlefield setting [1], to mild concussion from blunt trauma. This study used both weight drop in mice and fluid percussion injury in rats. These were chosen to simulate either mild or moderate traumatic brain injury (TBI). For mice, we used novel object recognition and the Y maze. For rats, we used the Morris water maze. NAC was administered beginning 30-60 minutes after injury. Behavioral deficits due to injury in both species were significantly reversed by NAC treatment. We thus conclude NAC produces significant behavioral recovery after injury. Future preclinical studies are needed to define the mechanism of action, perhaps leading to more effective therapies in man
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