The pathologists’ eyes on foregut: histopathological relations in the experimental and routine diagnostics

SUMMARY I. The study aimed to investigate the incidence of duodeno-gastroesophageal reflux-induced malignoma formation in a series of duodeno-esophageal anastomosis operations in rats. This surgical method provided a model for the reflux-induced esophageal pathologies, without carcinogen administration. 30 weeks of duodeno-gastroesophageal reflux disease significantly increased the risk of the development of BE, and reflux-induced EAC formation was evident in 4 animals. In one of these particular cases, a superficial squamous cell cancer was noted in close vicinity to the adenocarcinoma formation. The results of the applied rat model afford evidence of the simultaneous activation of more than one possible carcinogenetic pathway in experimental GERD. Synchronous neoplasm formation with different growth pattern characteristics is a rarity in humans, and this phenomenon suggests that the presented model is a suitable means of mimicking the whole spectrum of human GERD pathology. II/1. The study aimed to carry out standardized histopathological analysis focusing not only on SIM but also on the presence of additional glands in the metaplastic process at 826 consecutive patients. According to standardized histopathological dataset the cases were classified and recorded by computerized method. The obtained data proved that 1) pure SIM is very rare in the Hungarian population, 2) cardiac and superficial mucous glands are good predictors for SIM, 3) pancreatic acinar and fundic metaplasias carry less severe metaplastic process, and 4) superficial mucous glands can be responsible for creating foregut-derived tissues and thus can be the origin of BE. II/2. The study aimed to assess the value of forceps biopsy sampling in establishing the correct diagnosis revealed by EMR as well as to evaluate the efficacy of this method. Fifty-six subjects with sessile gastric polyps of epithelial origin, at least 0.5 cm in diameter, and not associated with polyposis syndromes, were included. The obtained data showed that forceps biopsy is not fully representative of the entire lesion, and a simple biopsy may therefore lead to a faulty differentiation between the neoplastic and non-neoplastic lesions. EMR proposes diagnostic and staging advantage in assessing patients with EGC as compared to forceps biopsy, because it provides more intact mucosa and submucosa for histological analysis. Sessile gastric polyps should be fully resected by EMR for a final diagnosis and (depending on the lesion size and type) possibly definitive treatment

Accurate Frequency Domain Modelling of an Electric Furnace

Controllers of industrial furnaces may operate differently in different temperature ranges. The controller has different parameter sets for each of these ranges. The operation of controllers is switched according to the temperature. It is desirable to change the parameters continuously following the temperature. The continuous change of parameters instead of mode switching may decrease the switching transients and lead to more accurate temperature control. A laboratory-scale electric furnace is investigated in this paper. The main focus is on the temperature dependent behavior of the furnace. The objective is to build up a temperature dependent model that is capable to describe the furnace in a wider temperature range

Des nouvelles tendances du concept de l'autonomie locale en Hongrie

Gérard Marcou professzor, a párizsi Sorbonne egyetem tanára,az Európai Helyi Önkormányzati Kutatócsoport (GRALE) vezetőjének elhúnyta alkalmából, tiszteletére készített nemzetközi "Mélange"-ba készült fejezet

Administrative Law in the Time of Corona(virus): Resiliency of the Hungarian Administrative Law?

The Hungarian administrative law has been significantly impacted by the COVID-19 pandemic. Several rules – which were introduced during the state of danger based on the epidemic situation – have been incorporated into the Hungarian legal system. The administrative procedural law has been influenced by the epidemic transformation. However, the rules on e-administration have not been reformed significantly (due to the digitalisation reforms of the last years), but the rules on administrative licenses and permissions have been amended. The priority of the general code on administrative procedure has been weakened: new, simplified procedure and regime have been introduced. The local self-governance has been impacted by the reforms. The transformation has had two opposite trends. On the one hand, the Hungarian administrative system became more centralised during the last year: municipal revenues and task performance has been partly centralised. The Hungarian municipal system has been concentrated, as well. The role of the second-tier government, the counties (megye), has been strengthened by the establishment of the special economic (investment) zones. On the other hand, the municipalities could be interpreted as a “trash can” of the Hungarian public administration

Anisotropy of the sky distribution of gamma-ray bursts

The isotropy of gamma-ray bursts collected in current BATSE catalog is studied. It is shown that the quadrupole term being proportional to \sim sin 2b sin l is non-zero with a probability of 99.9%. The occurrence of this anisotropy term is then confirmed by the binomial test even with the probability of 99.97 %. Hence, the sky distribution of all known gamma-ray bursts is anisotropic. It is also argued that this anisotropy cannot be caused exclusively by instrumental effects due to the nonuniform sky exposure of BATSE instrument. Separating the GRBs into short and long subclasses, it is shown that the short ones are distributed anisotropically, but the long ones seem to be distributed still isotropically. The character of anisotropy suggests that the cosmological origin of short GRBs further holds, and there is no evidence for their Galactical origin