Fingolimod modulates microglial activation to augment markers of remyelination

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Signalling Intent: Beacons, Lookouts and Military Communications

Beacons and lookouts played a key role in the networks of local and regional communications of Anglo-Saxon England during the Viking Age (ninth to eleventh centuries). While the large fortified centres of the period are well known, the nature of interconnections between them and smaller-scale local arrangements have only recently received attention. Written evidence, place-names and landscape archaeology together allow for the reconstruction of elements of signalling and sighting systems. This contribution presents the historical evidence for beacons, discusses the context within which beacons and lookouts developed and draws upon a series of case studies to reveal local systems of communication in the landscape of Anglo-Saxon England

The suitcase, the samurai sword and the pumpkin: Asian crime and news media treatment

In 2005 and 2007, two high profile crimes were reported in the New Zealand media. The first case involved the murder of a young Chinese student, Wan Biao, whose dismembered body was discovered in a suitcase. The second case involved domestic violence in which a Chinese man murdered his wife and fled the scene with their young daughter - who the press later dubbed 'Pumpkin' when she was found abandoned in Melbourne, Australia. The authors discuss how news and current affairs programmes decontextualise 'Asian' stories to portray a clear divide between the 'New Zealand' public and the separate 'Asian other'. Asians are portrayed as a homogenous group and the media fails to distinguish between Asians as victims of crimes as a separate category to Asians as perpetrators of crimes. This may have consequences for the New Zealand Asian communities and the wider New Zealand society as a whole

A cognitive neuropsychological and psychophysiological investigation of a patient who exhibited an acute exacerbated behavioural response during innocuous somatosensory stimulation and movement.

We report findings from a cognitive neuropsychological and psychophysiological investigation of a patient who displayed an exacerbated acute emotional expression during movement, innocuous, and aversive somatosensory stimulation. The condition developed in the context of non-specific white matter ischaemia along with abnormalities in the cortical white matter of the left anterior parietal lobe, and subcortical white matter of the left Sylvian cortex. Cognitive neuropsychological assessment revealed a pronounced deficiency in executive function, relative to IQ, memory, attention, language and visual processing. Compared to a normal control group, the patient [EQ] displayed a significantly elevated skin conductance level during both innocuous and aversive somatosensory stimulation. His pain tolerance was also significantly reduced. Despite this, EQ remained able to accurately describe the form of stimulation taking place, and to rate the levels of pain intensity and pain affect. These results suggest that EQ's exaggerated behavioural response and reduced pain tolerance to somatosensory stimulation may be linked to cognitive changes, possibly related to increased apprehension and fear, rather than altered pain intensity or pain affect per se

Studies of Jets, Subjets and Higgs Searches with The ATLAS Detector

Measurements are made on data collected at a centre-of-mass energy of 7 TeV using the ATLAS detector at the LHC. Jets from non-collision sources for the inclusive jet cross-section are evaluated for jet transverse momentum values from 20 GeV to 1.5 TeV and for rapidity values up to |y| < 4.4. Measurements are made using anti-kT jets with the distance parameters R = 0.4 and R = 0.6, corresponding to 37 pb−1 of data. Analysis of the sub-structure of QCD jets at high transverse momentum is performed using anti-kT R = 1.0 and Cambridge-Aachen R = 1.2, using 35 pb−1 of data. The first measurement of jet mass is presented

Pruritus is a common feature in sheep infected with the BSE agent.

BACKGROUND: The variability in the clinical or pathological presentation of transmissible spongiform encephalopathies (TSEs) in sheep, such as scrapie and bovine spongiform encephalopathy (BSE), has been attributed to prion protein genotype, strain, breed, clinical duration, dose, route and type of inoculum and the age at infection. The study aimed to describe the clinical signs in sheep infected with the BSE agent throughout its clinical course to determine whether the clinical signs were as variable as described for classical scrapie in sheep. The clinical signs were compared to BSE-negative sheep to assess if disease-specific clinical markers exist. RESULTS: Forty-seven (34%) of 139 sheep, which comprised 123 challenged sheep and 16 undosed controls, were positive for BSE. Affected sheep belonged to five different breeds and three different genotypes (ARQ/ARQ, VRQ/VRQ and AHQ/AHQ). None of the controls or BSE exposed sheep with ARR alleles were positive. Pruritus was present in 41 (87%) BSE positive sheep; the remaining six were judged to be pre-clinically infected. Testing of the response to scratching along the dorsum of a sheep proved to be a good indicator of clinical disease with a test sensitivity of 85% and specificity of 98% and usually coincided with weight loss. Clinical signs that were displayed significantly earlier in BSE positive cases compared to negative cases were behavioural changes, pruritic behaviour, a positive scratch test, alopecia, skin lesions, teeth grinding, tremor, ataxia, loss of weight and loss of body condition. The frequency and severity of each specific clinical sign usually increased with the progression of disease over a period of 16-20 weeks. CONCLUSION: Our results suggest that BSE in sheep presents with relatively uniform clinical signs, with pruritus of increased severity and abnormalities in behaviour or movement as the disease progressed. Based on the studied sheep, these clinical features appear to be independent of breed, affected genotype, dose, route of inoculation and whether BSE was passed into sheep from cattle or from other sheep, suggesting that the clinical phenotype of BSE is influenced by the TSE strain more than by other factors. The clinical phenotype of BSE in the genotypes and breed studied was indistinguishable from that described for classical scrapie cases

Two Years Later: Journals Are Not Yet Enforcing the ARRIVE Guidelines on Reporting Standards for Pre-Clinical Animal Studies

There is growing concern that poor experimental design and lack of transparent reporting contribute to the frequent failure of pre-clinical animal studies to translate into treatments for human disease. In 2010, the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were introduced to help improve reporting standards. They were published in PLOS Biology and endorsed by funding agencies and publishers and their journals, including PLOS, Nature research journals, and other top-tier journals. Yet our analysis of papers published in PLOS and Nature journals indicates that there has been very little improvement in reporting standards since then. This suggests that authors, referees, and editors generally are ignoring guidelines, and the editorial endorsement is yet to be effectively implemented