1,383 research outputs found
Field testing a novel high residence positioning system for monitoring the fineâscale movements of aquatic organisms
1. Acoustic telemetry is an important tool for studying the behaviour of aquatic organisms in the wild.
2. VEMCO high residence (HR) tags and receivers are a recent introduction in the field of acoustic telemetry and can be paired with existing algorithms (e.g. VEMCO positioning system [VPS]) to obtain highâresolution twoâdimensional positioning data.
3. Here, we present results of the first documented field test of a VPS composed of HR receivers (hereafter, HRâVPS). We performed a series of stationary and moving trials with HR tags (mean HR transmission period = 1.5 s) to evaluate the precision, accuracy and temporal capabilities of this positioning technology. In addition, we present a sample of data obtained for five European perch Perca fluviatilis implanted with HR tags (mean HR transmission period = 4 s) to illustrate how this technology can estimate the fineâscale behaviour of aquatic animals.
4. Accuracy and precision estimates (median [5thâ95th percentile]) of HRâVPS positions for all stationary trials were 5.6 m (4.2â10.8 m) and 0.1 m (0.02â0.07 m), respectively, and depended on the location of tags within the receiver array. In moving tests, tracks generated by HRâVPS closely mimicked those produced by a handheld GPS held over the tag, but these differed in location by an average of â9 m.
5. We found that estimates of animal speed and distance travelled for perch declined when positional data for acoustically tagged perch were thinned to mimic longer transmission periods. These data also revealed a tradeâoff between capturing real nonlinear animal movements and the inclusion of positioning error.
6. Our results suggested that HRâVPS can provide more representative estimates of movement metrics and offer an advancement for studying fineâscale movements of aquatic organisms, but highâprecision survey techniques may be needed to test these systems
Massive perturbers and the efficient merger of binary massive black holes
We show that dynamical relaxation in the aftermath of a galactic merger and
the ensuing formation and decay of a binary massive black hole (MBH), are
dominated by massive perturbers (MPs) such as giant molecular clouds or
clusters. MPs accelerate relaxation by orders of magnitude relative to 2-body
stellar relaxation alone, and efficiently scatter stars into the binary MBH's
orbit. The 3-body star-binary MBH interactions shrink the binary MBH to the
point where energy losses from the emission of gravitational waves (GW) lead to
rapid coalescence. We model this process based on observed and simulated MP
distributions and take into account the decreased efficiency of the star-binary
MBH interaction due to acceleration in the galactic potential. We show that
mergers of gas-rich galactic nuclei lead to binary MBH coalescence well within
the Hubble time. Moreover, lower-mass binary MBHs (<10^8 Msun) require only a
few percent of the typical gas mass in a post-merger nucleus to coalesce in a
Hubble time. The fate of a binary MBH in a gas poor galactic merger is less
certain, although massive stellar structures (e.g. clusters, stellar rings)
could likewise lead to efficient coalescence. These coalescence events are
observable by their strong GW emission. MPs thus increase the cosmic rate of
such GW events, lead to a higher mass deficit in the merged galactic core and
suppress the formation of triple MBH systems and the resulting ejection of MBHs
into intergalactic space.Comment: 14 pages, 4 figures, 3 tables. More detailed explanations and changes
in structure. Section on hypervelocity stars moved to another paper (in
preparation). Results and conclusions unchanged. Accepted to Ap
Effects of national housing quality standards on hospital emergency admissions: a quasi-experiment using data-linkage
Background
National housing quality standards are now being applied throughout the UK. The Welsh Government has introduced the Welsh Housing Quality Standards. A housing improvement programme in Wales has been delivered through one local authority to bring 9500 homes up to standard. Homes received multiple elements, including new kitchens, bathrooms, windows and doors, boilers, insulation, and wiring, through an 8 year rolling work programme. The study aimed to determine the impacts of the different housing improvements on hospital emergency admissions for residents over 60 years of age.
Methods
Intervention homes (council homes that received at least one element of work) were data linked to individual health records of residents. Counts of admissions for respiratory and cardiovascular conditions, and for falls and burns, were obtained retrospectively for each individual in a dynamic housing cohort (Jan 1, 2005, to March 31, 2015). The criterion for the intervention cohort was for someone to have lived in any one of the 9500 intervention homes for at least 3 months within the intervention period. Counts were captured for up to 123 consecutive months for 7054 individuals in the intervention cohort and analysed in a multilevel approach to account for repeated observations for individuals, nested within geographical areas. Negative binomial regression models were constructed to determine the effect on emergency admissions for those living in homes compliant for each element of work compared with those living in homes that were non-compliant at that time. We adjusted for background trends in the regional general population, and for other confounding factors.
Findings
For residents 60 years old and over there was a reduction in admissions for people with compliant boilers (rate ratio 0·71, 95% CI 0·67â0·76), loft insulation (0·87, 0·80â0·95), wall insulation (0·74, 0·69â0·80), and windows and doors (0·56, 0·52â0·61) compared with those living in homes that were non-compliant for those work elements.
Interpretation
Improving housing to national standards reduces the number of emergency admissions to hospital for older residents. Strengths of the data-linkage approach included the retrospective collection of complete baseline and follow-up data using routine data for a long-term intervention, and large scale regional adjustment
The structure and function of complex networks
Inspired by empirical studies of networked systems such as the Internet,
social networks, and biological networks, researchers have in recent years
developed a variety of techniques and models to help us understand or predict
the behavior of these systems. Here we review developments in this field,
including such concepts as the small-world effect, degree distributions,
clustering, network correlations, random graph models, models of network growth
and preferential attachment, and dynamical processes taking place on networks.Comment: Review article, 58 pages, 16 figures, 3 tables, 429 references,
published in SIAM Review (2003
Dissociation in a polymerization model of homochirality
A fully self-contained model of homochirality is presented that contains the
effects of both polymerization and dissociation. The dissociation fragments are
assumed to replenish the substrate from which new monomers can grow and undergo
new polymerization. The mean length of isotactic polymers is found to grow
slowly with the normalized total number of corresponding building blocks.
Alternatively, if one assumes that the dissociation fragments themselves can
polymerize further, then this corresponds to a strong source of short polymers,
and an unrealistically short average length of only 3. By contrast, without
dissociation, isotactic polymers becomes infinitely long.Comment: 16 pages, 6 figures, submitted to Orig. Life Evol. Biosp
Homochiral growth through enantiomeric cross-inhibition
The stability and conservation properties of a recently proposed
polymerization model are studied. The achiral (racemic) solution is linearly
unstable once the relevant control parameter (here the fidelity of the
catalyst) exceeds a critical value. The growth rate is calculated for different
fidelity parameters and cross-inhibition rates. A chirality parameter is
defined and shown to be conserved by the nonlinear terms of the model. Finally,
a truncated version of the model is used to derive a set of two ordinary
differential equations and it is argued that these equations are more realistic
than those used in earlier models of that form.Comment: 20 pages, 6 figures, Orig. Life Evol. Biosph. (accepted
Allelic Variation in \u3cem\u3eCXCL16\u3c/em\u3e Determines CD3\u3csup\u3e+\u3c/sup\u3e T Lymphocyte Susceptibility to Equine Arteritis Virus Infection and Establishment of Long-Term Carrier State in the Stallion
Equine arteritis virus (EAV) is the causative agent of equine viral arteritis (EVA), a respiratory, systemic, and reproductive disease of horses and other equid species. Following natural infection, 10â70% of the infected stallions can become persistently infected and continue to shed EAV in their semen for periods ranging from several months to life. Recently, we reported that some stallions possess a subpopulation(s) of CD3+ T lymphocytes that are susceptible to in vitro EAV infection and that this phenotypic trait is associated with long-term carrier status following exposure to the virus. In contrast, stallions not possessing the CD3+ T lymphocyte susceptible phenotype are at less risk of becoming long-term virus carriers. A genome wide association study (GWAS) using the Illumina Equine SNP50 chip revealed that the ability of EAV to infect CD3+ T lymphocytes and establish long-term carrier status in stallions correlated with a region within equine chromosome 11. Here we identified the gene and mutations responsible for these phenotypes. Specifically, the work implicated three allelic variants of the equine orthologue of CXCL16 (EqCXCL16) that differ by four non-synonymous nucleotide substitutions (XM_00154756; c.715 A â T, c.801 G â C, c.804 T â A/G, c.810 G â A) within exon 1. This resulted in four amino acid changes with EqCXCL16S (XP_001504806.1) having Phe, His, Ile and Lys as compared to EqCXL16R having Tyr, Asp, Phe, and Glu at 40, 49, 50, and 52, respectively. Two alleles (EqCXCL16Sa, EqCXCL16Sb) encoded identical protein products that correlated strongly with long-term EAV persistence in stallions (P \u3c 0.000001) and are required for in vitro CD3+ T lymphocyte susceptibility to EAV infection. The third (EqCXCL16R) was associated with in vitro CD3+ T lymphocyte resistance to EAV infection and a significantly lower probability for establishment of the long-term carrier state (viral persistence) in the male reproductive tract. EqCXCL16Sa and EqCXCL16Sb exert a dominant mode of inheritance. Most importantly, the protein isoform EqCXCL16S but not EqCXCL16R can function as an EAV cellular receptor. Although both molecules have equal chemoattractant potential, EqCXCL16S has significantly higher scavenger receptor and adhesion properties compared to EqCXCL16R
Equine Arteritis Virus Uses Equine CXCL16 as an Entry Receptor
Previous studies in our laboratory have identified equine CXCL16 (EqCXCL16) to be a candidate molecule and possible cell entry receptor for equine arteritis virus (EAV). In horses, the CXCL16 gene is located on equine chromosome 11 (ECA11) and encodes a glycosylated, type I transmembrane protein with 247 amino acids. Stable transfection of HEK-293T cells with plasmid DNA carrying EqCXCL16 (HEK-EqCXCL16 cells) increased the proportion of the cell population permissive to EAV infection from \u3c 3% to almost 100%. The increase in permissiveness was blocked either by transfection of HEK-EqCXCL16 cells with small interfering RNAs (siRNAs) directed against EqCXCL16 or by pretreatment with guinea pig polyclonal antibody against EqCXCL16 protein (Gp anti-EqCXCL16 pAb). Furthermore, using a virus overlay protein-binding assay (VOPBA) in combination with far-Western blotting, gradient-purified EAV particles were shown to bind directly to the EqCXCL16 protein in vitro. The binding of biotinylated virulent EAV strain Bucyrus at 4°C was significantly higher in HEK-EqCXCL16 cells than nontransfected HEK-293T cells. Finally, the results demonstrated that EAV preferentially infects subpopulations of horse CD14+ monocytes expressing EqCXCL16 and that infection of these cells is significantly reduced by pretreatment with Gp anti-EqCXCL16 pAb. The collective data from this study provide confirmatory evidence that the transmembrane form of EqCXCL16 likely plays a major role in EAV host cell entry processes, possibly acting as a primary receptor molecule for this virus
Demonstrating the validity of the Video Game Functional Assessment-Revised (VGFA-R)
Problematic video play has been well documented over the course of the last decade. So much so the DSM-5 (APA, 2013) has included problematic video gaming as disorder categorized as Internet Gaming Disorder. The field of applied behavior analysis has been utilizing functional assessments for the last 30 years and has showed evidence of effective results across different populations and environments. Therefore, the purpose of this investigation (comprising three studies) was to validate an indirect functional assessment entitled the Video Game Functional Assessment-Revised (VGFA-R). Using academic experts in the field of video game addiction and applied behavioral analysis (n=6), the first study examined the content validity of the VGFA-R and was able to demonstrate the assessment exceeded the criterion for an established assessment. A second study comprising a survey of 467 gamers examined the factorability by using a confirmatory factor analysis, and found that VGFA-R had an overall variance above .60. Within the third laboratory-based study using gamers (n=11), the VGFA-R was examined for construct validity and found the VGFA-R was able to predict 85% of the appropriate function of behavior. Implications of the study are discussed along with the strengths and limitations of the study and future research directions
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