The Iowa Homemaker vol.1, no.3-4

Table of Contents Carrie Chapman Catt Returns to Iowa State College by Clara Jordan, page 1 A Neighborhood Playground by Juanita Beard, page 2 Baby’s Health Insurance – Proper Feeding by Belle Lowe, page 3 Summer Salad Possibilities by Beth Bailey, page 4 Iowa’s Nutrition Classes for School Children by Gladys Dodge, page 6 Little Frocks for Little Tots by Mildred Elder, page 7 Why Do You Buy Your Hat? by Margaret Kingery, page

The Iowa Homemaker vol.1, no.8

Table of Contents An Appreciation of the Life of Dean MacKay compiled by Clara Jordan, page 1 Iowa Members of W. C. T. U. Meet by Helen Paschal, page 2 What Shall We Have for Thanksgiving Dinner? by Beth Bailey, page 3 Things to Know About the School Lunch Basket by Millie Lerdall and Grace McIlrath, page 4 Do You Know What’s In a Can? by Blanche Ingersoll, page 5 “La Chambre D’Ami” in An Iowa Home by Eda Lord Murphy, page 6 “Looking In” on Home Economics at Iowa State by An Alumna, page 6 Pumpkin Pies They Don’t Forget by Viola M. Bell, page

Dismembering organisation: The coordination of algorithmic work in healthcare

Algorithms are increasingly being adopted in healthcare settings, promising increased safety, productivity and efficiency. The growing sociological literature on algorithms in healthcare shares an assumption that algorithms are introduced to ‘support’ decisions within an interactive order that is predominantly human-oriented. We present a different argument, calling attention to the manner in which organisations can end up introducing a non-negotiable disjuncture between human initiated care work and work that supports algorithms, which we call algorithmic work. Drawing on an ethnographic study, we describe how two hospitals in England implemented an Acute Kidney Injury (AKI) algorithm and we analyse ‘interruptions’ to the algorithm’s expected performance. When the coordination of algorithmic work occludes care work, we find a ‘dismembered’ organisation that is algorithmically-oriented rather than human-oriented. In our discussion, we examine the consequences of coordinating human and non-human work in each hospital and conclude by urging sociologists of organisation to attend to the importance of the formal in algorithmic work. As the use of algorithms becomes widespread, our analysis provides insight into how organisations outside of healthcare can also end up severing tasks from human experience when algorithmic automation is introduced

The Iowa Homemaker vol.1, no.9

Table of Contents Aunt Sarah’s Portrait and the Frame that Matched by Ruth Safford, page 1 Hymns for Christmas Day and Every Day by Eda Lord Murphy, page 2 Buffet Service Makes Holiday Entertainment Easy by Helen Paschal, page 3 The Art of Framing and Hanging Pictures by Joanna M. Hansen, page 4 Christmas Gifts From My Christmas Paint Shop by Mildred Elder, page 5 Home Made Toys for Tiny Tots by Clara Jordan, page 6 By Her Clothes You Shall Know Her by Ruth Spencer, page 7 Why Not a Christmas Plum Pudding Sale? by Willetta Moore, page 8 Christmas Sweets You Will Want to Make by Beth Bailey, page 8 A Unique Nutrition Clinic by Ione Johnson, page 1

ClusterCAD: a computational platform for type I modular polyketide synthase design

ClusterCAD is a web-based toolkit designed to leverage the collinear structure and deterministic logic of type I modular polyketide synthases (PKSs) for synthetic biology applications. The unique organization of these megasynthases, combined with the diversity of their catalytic domain building blocks, has fueled an interest in harnessing the biosynthetic potential of PKSs for the microbial production of both novel natural product analogs and industrially relevant small molecules. However, a limited theoretical understanding of the determinants of PKS fold and function poses a substantial barrier to the design of active variants, and identifying strategies to reliably construct functional PKS chimeras remains an active area of research. In this work, we formalize a paradigm for the design of PKS chimeras and introduce ClusterCAD as a computational platform to streamline and simplify the process of designing experiments to test strategies for engineering PKS variants. ClusterCAD provides chemical structures with stereochemistry for the intermediates generated by each PKS module, as well as sequence- and structure-based search tools that allow users to identify modules based either on amino acid sequence or on the chemical structure of the cognate polyketide intermediate. ClusterCAD can be accessed at https://clustercad.jbei.org and at http://clustercad.igb.uci.edu

The Iowa Homemaker vol.2, no.3-4

Table of Contents What Do You Choose in Table Service? by Clara Jordan, page 1 The Home We Had to Have – and Had It by Katherine Goeppinger, page 2 Preparing to Meet the Linen Needs of Bridedom by Helen Paschal, page 3 Canning Without Mother for a Helper by Carrie Plunkett, page 4 Summing Up the Serving of Well Planned Meals by N. Beth Bailey, page 5 Finding Brushes to Fit Special Needs by Glenna Hesse, page 6 Bridal Showers of Blessings by Harriet Schleiter, page 7 The Art of Garnishing Foods by Mildred B. Elder, page 7 Who’s There and Where by Jeanette Beyer, page 10 Seasonable Desserts of Fruits and Berries by N. Beth Bailey, page 11 Forget It All-And a Picnicking Go! by Eleanor Murray, page 1

Cost-Effectiveness of Non-Statin Lipid-Modifying Agents for Primary and Secondary Prevention of Cardiovascular Disease among Patients with Type 2 diabetes mellitus: A Systematic Review

Background: Non-statin therapies (NSTs) have been shown to provide additional benefits for cardiovascular risk reduction among patients with type 2 diabetes mellitus (T2DM), but their economic merits have not been confirmed. The objective of this systematic review is to evaluate the cost-effectiveness of NSTs for primary and secondary prevention of cardiovascular disease (CVD) in T2DM patients. 1 Methods: A literature search was systematically performed using MeSH terms (Table 1) from January 1990 to January 2021 in ten databases (e.g. MEDLINE, PubMed, and EconLit). Two reviewers independently screened the included studies that evaluated the cost-effectiveness of NSTs versus any comparator. Quality of Health Economic Studies (QHES) checklist was used for quality assessment. 2 Cost outputs were adapted to 2019 United States dollars (USD) to facilitate comparisons between studies. 3 Results: The search identified 21,182 records. Of which, 10,781 records were screened based on the title and abstract, and 185 articles based on the full text (Figure 1). After a full-text review, 12 studies were included in this study, where eight studies evaluated ezetimibe, four evaluated Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) inhibitors, two evaluated fenofibrate, one evaluated nicotinic acid, and one evaluated extended-release niacin/laropiprant (ER-ERN/LRPT). Six out of eight studies considered ezetimibe plus statin to be a cost-effective therapy for patients with T2DM and with or without CVD, three out of four studies suggested that PCSK9 inhibitors were not cost-effective. Fenofibrate, nicotinic acid, and ER- ERN/LRPT were cost-effective. Based on QHES, the majority of economic evaluations had good quality of reporting. The ICERs were consistent in the majority of studies after adaptation to 2019 USD values. 1-3 Conclusion: The systematic review demonstrated that most cost-effectiveness studies considered NSTs to be cost-effective compared with standard care but not PCSK9 inhibitors for primary and secondary prevention of CVD in T2DM patients.qscienc

North Atlantic Midlatitude Surface-Circulation Changes Through the Plio-Pleistocene Intensification of Northern Hemisphere Glaciation

The North Atlantic Current (NAC) transports warm salty water to high northern latitudes, with important repercussions for ocean circulation and global climate. A southward displacement of the NAC and Subarctic Front, which separate subpolar and subtropical water masses, is widely suggested for the Last Glacial Maximum (LGM) and may have acted as a positive feedback in glacial expansion at this time. However, the role of the NAC during the intensification of Northern Hemisphere glaciation (iNHG) at ~3.5 to 2.5 Ma is less clear. Here we present new records from Integrated Ocean Drilling Program Site U1313 (41°N) spanning ~2.8–2.4 Ma to trace the influence of Subarctic Front waters above this mid‐latitude site. We reconstruct surface and permanent pycnocline temperatures and seawater δ18O using paired Mg/Ca‐δ18O measurements on the planktic foraminifers Globigerinoides ruber and Globorotalia crassaformis and determine abundances of the subpolar foraminifer Neogloboquadrina atlantica. We find that the first significant glacial incursions of Subarctic Front surface waters above Site U1313 did not occur until ~2.6 Ma. At no time during our study interval was (sub)surface reorganization in the midlatitude North Atlantic analogous to the LGM. Our findings suggest that LGM‐like processes sensu stricto cannot be invoked to explain interglacial‐glacial cycle amplification during iNHG. They also imply that increased glacial productivity at Site U1313 during iNHG was not only driven by southward deflections of the Subarctic Front. We suggest that nutrient injection from cold‐core eddies and enhanced glacial dust delivery may have played additional roles in increasing export productivity in the midlatitude North Atlantic from 2.7 Ma.t. Funding for this research was provided by IODP France (C. T. B.) and the German Research Foundation (DFG) (grant OF 2544/2 to O. F.). I. B. is grateful to the UK IODP for financial support for shipboard and post-cruise participation in IODP Exp. 306. C. T. B., K. T., T. D. G., L. V., C. S., and M. E. acknowledge OSU Pythéas. M. M. R. acknowledges support by the USGS Land Change Science Program