Effect of aging on the reinforcement efficiency of carbon nanotubes in epoxy matrix

The reinforcement efficiency of carbon nanotubes (CNTs) in epoxy matrix was investigated in the elastic regime. Cyclic uniaxial tensile tests were performed at constant strain amplitude and increasing maximum strain. Post-curing of the epoxy and its composite at a temperature close to the glass transition temperature allowed us to explore the effect of aging on the reinforcement efficiency of CNT. It is found that the reinforcement efficiency is compatible with a mean field mixture rule of stress reinforcement by random inclusions. It also diminishes when the maximum strain increased and this effect is amplified by aging. The decrease of elastic modulus with increasing cyclic maximum strain is quite similar to the one observed for filled elastomers with increasing strain amplitude, a phenomenon often referred as the Payne effect

Time-based conditions for synchronized procurement in Douki Seisan

This paper introduces the synchronous manufacturing philosophy (douki seisan) devised by Nissan, and relates it to “Just in Sequence”, a common technique in current automotive industry. Literature is full of case studies, and the advantages and drawbacks of JIS have been reported. However, no attempt to model the necessary relations to make this system work has been found. In this paper, the necessary conditions concerning the lead times and cycle times of the different activities are deduced, and even the moment when they should take place. They allow us to define a strongly synchronous system. For practitioners, each condition shows opportunities for process improvement. For researchers, lack of compliance with such conditions, gives rise to maximum satisfiability problems.Postprint (published version

Ethanol extract of Hedyotis diffusa willd. induction of apoptosis via PI3K/Akt and XIAP pathways in human leukemic THP-1 cells

Hedyotis diffusa (H. diffusa) Willd. is known to induce apoptosis in cancer cells. However, the molecular mechanism of its anti-cancer activity has not been fully elucidated. In this study, we found that the ethanol extract of H. diffusa Willd. (EEHDW) reduced cell viability and induced apoptosis in a dose- and time-dependent manner in human leukemic THP-1 cells. The induction of apoptosis was also accompanied by the down regulation of PI3K/Akt and the inhibitor of apoptosis protein (IAP) family proteins. Moreover, we observed that EEHDW treatment resulted in activation of caspase-3, which may partly explain the anti-cancer activity of EEHDW.Key words: Hedyotis diffusa Willd., THP-1, apoptosis, caspase

Thermal Assisted Oxygen Annealing for High Efficiency Planar CH3NH3PbI3 Perovskite Solar Cells

published_or_final_versio

Message from the ICASE 2011 organizers

published_or_final_versionThe 9th IEEE International Symposium on Parallel and Distributed Processing with Applications Workshops (ISPAW 2011), Busan, Korea, 26-28 May 2011. In Proceedings of the ISPAW, 2011, p. xxx

Diffusion Index Model Specification and Estimation Using Mixed Frequency Datasets

In this chapter, we discuss the use of mixed frequency models and diffusion index approximation methods in the context of prediction. In particular, select recent specification and estimation methods are outlined, and an empirical illustration is provided wherein U.S. unemployment forecasts are constructed using both classical principal components based diffusion indexes as well as using a combination of diffusion indexes and factors formed using small mixed frequency datasets. Preliminary evidence that mixed frequency based forecasting models yield improvements over standard fixed frequency models is presented

High resolution mapping of a novel late blight resistance gene Rpi-avll, from the wild Bolivian species Solanum avilesii

Both Mexico and South America are rich in Solanum species that might be valuable sources of resistance (R) genes to late blight (Phytophthora infestans). Here, we focus on an R gene present in the diploid Bolivian species S. avilesii. The genotype carrying the R gene was resistant to eight out of 10 Phytophthora isolates of various provenances. The identification of a resistant phenotype and the generation of a segregating population allowed the mapping of a single dominant R gene, Rpi-avl1, which is located in an R gene cluster on chromosome 11. This R gene cluster is considered as an R gene “hot spot”, containing R genes to at least five different pathogens. High resolution mapping of the Rpi-avl1 gene revealed a marker co-segregating in 3890 F1 individuals, which may be used for marker assisted selection in breeding programs and for further cloning of Rpi-avl

Explaining the t tbar forward-backward asymmetry without dijet or flavor anomalies

We consider new physics explanations of the anomaly in the top quark forward-backward asymmetry measured at the Tevatron, in the context of flavor conserving models. The recently measured LHC dijet distributions strongly constrain many otherwise viable models. A new scalar particle in the antitriplet representation of flavor and color can fit the t tbar asymmetry and cross section data at the Tevatron and avoid both low- and high-energy bounds from flavor physics and the LHC. An s-channel resonance in uc to uc scattering at the LHC is predicted to be not far from the current sensitivity. This model also predicts rich top quark physics for the early LHC from decays of the new scalar particles. Single production gives t tbar j signatures with high transverse momentum jet, pair production leads to t tbar j j and 4 jet final states.Comment: 7 pages, 6 figures; v2: notation clarified, references adde

Mitochondrial DNA Copy Number Is Associated with Breast Cancer Risk

Mitochondrial DNA (mtDNA) copy number in peripheral blood is associated with increased risk of several cancers. However, data from prospective studies on mtDNA copy number and breast cancer risk are lacking. We evaluated the association between mtDNA copy number in peripheral blood and breast cancer risk in a nested case-control study of 183 breast cancer cases with pre-diagnostic blood samples and 529 individually matched controls among participants of the Singapore Chinese Health Study. The mtDNA copy number was measured using real time PCR. Conditional logistic regression analyses showed that there was an overall positive association between mtDNA copy number and breast cancer risk (Ptrend = 0.01). The elevated risk for higher mtDNA copy numbers was primarily seen for women with <3 years between blood draw and cancer diagnosis; ORs (95% CIs) for 2nd, 3rd, 4th, and 5th quintile of mtDNA copy number were 1.52 (0.61, 3.82), 2.52 (1.03, 6.12), 3.12 (1.31, 7.43), and 3.06 (1.25, 7.47), respectively, compared with the 1st quintile (Ptrend = 0.004). There was no association between mtDNA copy number and breast cancer risk among women who donated a blood sample ≥3 years before breast cancer diagnosis (Ptrend = 0.41). This study supports a prospective association between increased mtDNA copy number and breast cancer risk that is dependent on the time interval between blood collection and breast cancer diagnosis. Future studies are warranted to confirm these findings and to elucidate the biological role of mtDNA copy number in breast cancer risk. © 2013 Thyagarajan et al

Uptake and transport of novel amphiphilic polyelectrolyte-insulin nanocomplexes by caco-2 cells - towards oral insulin

“The original publication is available at www.springerlink.com”. Copyright SpringerPurpose: The influence of polymer architecture on cellular uptake and transport across Caco-2 cells of novel amphiphilic polyelectrolyte-insulin nanocomplexes was investigated. Method: Polyallylamine (PAA) (15 kDa) was grafted with palmitoyl chains (Pa) and subsequently modified with quaternary ammonium moieties (QPa). These two amphiphilic polyelectrolytes (APs) were tagged with rhodamine and their uptake by Caco-2 cells or their polyelectrolyte complexes (PECs) with fluorescein isothiocyanate-insulin (FITC-insulin) uptake were investigated using fluorescence microscopy. The integrity of the monolayer was determined by measurement of transepithelial electrical resistance (TEER). Insulin transport through Caco-2 monolayers was determined during TEER experiments. Result: Pa and insulin were co-localised in the cell membranes while QPa complexes were found within the cytoplasm. QPa complex uptake was not affected by calcium, cytochalasin D or nocodazole. Uptake was reduced by co-incubation with sodium azide, an active transport inhibitor. Both polymers opened tight junctions reversibly where the TEER values fell by up to 35 % within 30 minutes incubation with Caco-2 cells. Insulin transport through monolayers increased when QPa was used (0.27 ngmL-1 of insulin in basal compartment) compared to Pa (0.14 ngmL-1 of insulin in basal compartment) after 2 hours. Conclusion: These APs have been shown to be taken up by Caco-2 cells and reversibly open tight cell junctions. Further work is required to optimise these formulations with a view to maximising their potential to facilitate oral delivery of insulin.Peer reviewe