The effects of global real economic crisis on the markets for fossil and renewable fuels

The 2008/2009 world economic crisis had significant impact on the oil and fuel markets. The crisis developed from the meltdown of American and European mortgage and financial markets and rapidly involved the global real economy. As each country reacted differently to the crisis, the changes in the fuel market also showed significant geographic variation. In our present research, the actions of the US, German and Hungarian fuel markets were analysed for the answer to the reasons for the differences in crisis reactions. We examined the tendency of fuel consumption, the changes of price elasticity for gasoline and diesel and the possible effects of the crisis on the regulatory system

Laser-scanning cytometry can quantify human adipocyte browning and proves effectiveness of irisin

Laser-scanning cytometry is presented as a tool allowing population scale analysis of ex vivo human brown adipogenic differentiation. It combines texture analysis and detection of Ucp1 protein content in single brown adipocytes of mixed cell populations with gene expression pattern and functional characteristics of browning. Using this method we could validate mouse data in human samples demonstrating the effectiveness of irisin to induce “beige” differentiation of subcutaneous white adipocytes.EUR 1,165 APC fee funded by the EC FP7 Post-Grant Open Access Pilo

Translational aspects of the microbiome-to be exploited

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Technical and environmental effects of biodiesel use in local public transport

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A poli(ADP-ribóz) polimeráz-2 szerepének vizsgálata a SIRT1 aktivációjában, az energiaháztartásban és a sejtek NAD+ koncentrációjának modulálásában = Investigation of the role of poly(ADP-ribose) polymerase-2 in SIRT1 activation, energy expenditure and the modulation of cellular NAD+ concentrations

A projekt során a poli(ADP-ribóz polimeráz (PARP) enzimek metabolikus szerepét vizsgálatuk. A PARP-1-/- egerekben a harántcsíkolt izomban és a barna zsírszövetben emelkedett biológiai oxidációt tapasztaltunk. A megemelkedett biológiai oxidáció oka a SIRT1 aktivitás megnövekedése volt. Eredményeinkből úgy tűnik, hogy elsődlegesen a fenti fenotípus megjelenéséért a PARP-1 és a SIRT1 NAD+ iránti versengése felelős: a PARP-1 enzim törlése esetén több NAD+ molekula marad a SIRT1 számára. Kimutattuk, hogy PARP inhibitorok is hasonló fenotípust alakítanak ki. PARP-2-/- egerekben a harántcsíkolt izomban és a májban emelkedett biológiai oxidációt írtunk le, amely szintén a megemelkedett mitokondriális aktivitással volt kapcsolatban, amit a megnövekvő SIRT1 expresszió váltott ki. A PARP-2-/- egerekben pancreas beta sejt diszfukciót találtunk, ami rontja az egerek metabolikus rátermettségét. Eredményeink egy új, farmakológiailag befolyásolható útvonalat írtak le, amelyen keresztül befolyásolható a szervezet energiaegyensúlya. | On course of the project we investigated the role of poly(ADP-ribose) polymerases in metabolic regulation. In the striated muscle and brown adipose tissue of the PARP-1-/- mice we have observed increased mitochondrial activity. The increased mitochondrial activity was linked to increased SIRT1 activity. Our results suggest that primarily the competition for the limiting NAD+ pool drive SIRT1 activation: upon the deletion of PARP-1 NAD+ levels increase providing more substrate for SIRT1. We provided evidence that PARP inhibitors are equally capable of inducing mitochondrial biogenesis. In the striated muscle and liver of PARP-2-/- mice we have observed increased mitochondrial activity that is equally linked to enhanced SIRT1 activation, however it was driven by increased SIRT1 expression. Besides the metabolically favorable enhanced energy expenditure we have observed pancreatic beta cell dysfunction that hinders metabolic fitness of these mice. Our data describe a novel pathway for the intervention on whole body energy balance, moreover this pathway can be influenced by pharmacological inhibitors

Deletion of poly(ADP?ribose) polymerase-1 changes the composition of the microbiome in the gut

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Oncobiosis and Microbial Metabolite Signaling in Pancreatic Adenocarcinoma

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