An Evaluation of Turkish Agricultural Production Performance

ABSTRACT In this study, productivity growth and technical changes in Turkish agriculture is measured for 1961 -2001 period using Cobb-Douglas production function. Ridge regression estimating technique is used. The results indicate that the annual output growth rates ranged from 1.30% to 3.40% for the Turkish agricultural production in each of the 10-years period. Farm output growth is mainly due to the use of tractors, labor, irrigation and fertilizer, which shows that most of the growth rate in output has been driven by continued increases in inputs. According to the results of analysis, technical change growth rates ranged from -0.15% to 5.53% over the 40-years period. Although the change has been low, there is a potential to achieve higher growth rates in agricultural production in the future if resources are used efficiently

NF-κB targeting by way of IKK inhibition sensitizes lung cancer cells to adenovirus delivery of TRAIL

<p>Abstract</p> <p>Background</p> <p>Lung cancer causes the highest rate of cancer-related deaths both in men and women. As many current treatment modalities are inadequate in increasing patient survival, new therapeutic strategies are required. TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in tumor cells but not in normal cells, prompting its current evaluation in a number of clinical trials. The successful therapeutic employment of TRAIL is restricted by the fact that many tumor cells are resistant to TRAIL. The goal of the present study was to test a novel combinatorial gene therapy modality involving adenoviral delivery of TRAIL (Ad5hTRAIL) and IKK inhibition (AdIKKβKA) to overcome TRAIL resistance in lung cancer cells.</p> <p>Methods</p> <p>Fluorescent microscopy and flow cytometry were used to detect optimum doses of adenovirus vectors to transduce lung cancer cells. Cell viability was assessed via a live/dead cell viability assay. Luciferase assays were employed to monitor cellular NF-κB activity. Apoptosis was confirmed using Annexin V binding.</p> <p>Results</p> <p>Neither Ad5hTRAIL nor AdIKKβKA infection alone induced apoptosis in A549 lung cancer cells, but the combined use of Ad5hTRAIL and AdIKKβKA significantly increased the amount of A549 apoptosis. Luciferase assays demonstrated that both endogenous and TRAIL-induced NF-κB activity was down-regulated by AdIKKβKA expression.</p> <p>Conclusions</p> <p>Combination treatment with Ad5hTRAIL and AdIKKβKA induced significant apoptosis of TRAIL-resistant A549 cells, suggesting that dual gene therapy strategy involving exogenous TRAIL gene expression with concurrent IKK inhibition may be a promising novel gene therapy modality to treat lung cancer.</p

A case of TSHoma mimicing Graves &apos;disease and makes GH cosecrete

Thyrotropinomas (TSHoma) are rare pituitary adenomas. TSHomas can synthesize other hormones simultaneously. Co-secretion of TSH and GH is rarely reported in the literature. In these patients, signs of hyperthyroidism and acromegaly can be observed together. Its clinic is heterogeneous and in some cases, symptoms of thyrotoxicosis may mask the acromegaly symptoms. Some TSHoma patients may also be mistakenly diagnosed with Graves and experience a delay in diagnosis. We aimed to present a unique case with a diagnosis of TSHoma, who was referred to our center when Euthyroidism was not achieved and was followed up with a pre-diagnosis of Graves and also had GH co-secretion. [Med-Science 2022; 11(4.000): 1734-7

A reasonable option in vitrectomized eyes:manual small incision cataract surgery

Letter to the edito

Mesleki ve Teknik Anadolu Lisesi Öğrencilerinin Staj Eğitiminden Beklentileri ve Yaşadıkları Sorunlar

&lt;p&gt;Staj uygulamaları öğrencilerin ve onları izleyen öğretim elemanlarının güncel ve canlı uygulamalara paralel olarak gelişen teknolojiyi takip etmelerini sağlar. Öğrencilerin işletmelerle iletişim kurmasını sağlayan ve mezun olduktan sonra kazandıkları referanslarla hızla değişen ve küreselleşen iş dünyasında istihdam edilmelerine yardımcı olan staj uygulamaları, mesleki eğitimde büyük bir öneme sahiptir. Bu çalışmada mesleki ve teknik Anadolu Lisesi öğrencilerinin staj eğitiminden beklentileri ile staj sürecinde karşılaştıkları sorunların analiz edilmesi amaçlanmaktadır. Nitel araştırma yöntemleri ile yürütülen çalışma fenomenoloji modeli kapsamındadır. Araştırmanın verileri araştırmacı tarafından hazırlanan yarı yapılandırılmış görüşme soruları kullanılarak elde edilmiştir. Görüşme formu Batman ilindeki mesleki ve teknik Anadolu Liselerinde eğitim gören 15 öğrenciye uygulanmıştır. Elde edilen veriler MAXQDA programı kullanılarak çözümlenmiştir. Araştırmanın sonunda öğrencilerin staj eğitiminden mesleki deneyim kazanmak, çalışma ortamını ve kültürünü anlamak, yeteneklerini keşfetmek ve ücret elde etmek gibi beklentiler içerisinde oldukları görülmüştür. Ayrıca öğrencilerin staj sürecinde aşırı iş yükü, stajyerlerin önemsenmemesi, eğitim ve rehberlik, teori ve uygulama uyumsuzluğu, yetersiz geri bildirim ve uyum sorunları gibi alanlarda sorunlarla karşılaştıkları belirlenmiştir.&nbsp;&lt;/p&gt

Comparison of intrahepatic vein-to-liver parenchyma and intercostal muscle-to-liver parenchyma strain ratios in the assessment of liver fibrosis: which one should we use?

WOS: 000351697000006PubMed: 25408430The aims of this study were to investigate whether there is a difference in diagnostic value between vein to parenchyma strain ratio (VPSR) and muscle to parenchyma strain ratio (MPSR). VPSR and MPSR were calculated via sonoelastography, and were recorded for comparison with histopathology. ROC analysis, the Mann-Whitney U test, the Kruskal-Wallis test, and Spearman's rank correlation test were used for statistical analysis. The study included 59 cases of individuals who underwent biopsy (29 women, 30 men). When the threshold value for VPSR was set at 3.23, the sensitivity was 96.2% and the specificity was 83.3% (p < 0.001, F a parts per thousand yen 1). When the threshold value was set at 3.01 for MPR, the sensitivity was 88.7% and the specificity was 83.3% (p < 0.001, F a parts per thousand yen 1). The areas under the curve values were VPSR 0.95 and MPSR 0.92 for F a parts per thousand yen 1, VPSR 0.94 and MPSR 0.92 for F a parts per thousand yen 2, and VPSR 1.00 and MPSR 0.76 for F = 3 (p < 0.001). The Spearman's correlation coefficient was 0.75, and a high positive concordance was found between VPSR and MPSR (p < 0.001). In this study, a high positive correlation was observed between two strain ratios, and VPSR was found to be more reliable than MPSR in determining liver fibrosis

Eye Involvement as the Initial Sign of Multiple Sclerosis in a Case with Familial Mediterranean Fever

Familial Mediterranean fever (FMF) is a common hereditary auto-inflammatory disease characterized by recurrent and selflimited attacks of serosal inflammation. The disease demonstrates an autosomal recessive inheritance pattern. Serositis can be observed as abdominal pain (peritonitis), chest pain (pleuritis) and joint pain (arthritis) usually accompanied by fever. The disease is more prevalent among the people living in the Middle East and Mediterranean regions. The prevalence ranges from 1/250 to 1/1000 depending upon the geographic locations [1]. Reports of ophthalmological manifestations in FMF are few and include retinal changes, panuveitis, anterior uveitis, scleritis, and episcleritis [2]. Multiple Sclerosis (MS) is a disease of the central nervous system characterized by multiple areas of inflammation and demyelination in the white matter of the brain and spinal cord [3]. Common neuro-ophthalmologic manifestation of MS is unilateral and painful vision loss due to optic neuritis. This is the first manifestation of MS, and usually appears as single-sided retrobulbar optic neuritis. Ocular motor deficits in multiple sclerosis include inter nuclear ophthalmoplegia (INO) and nystagmus, resulting in diplopia, oscillopsia, blurred vision, loss of stereopsis, and reading fatigue [3].</p