The last step to achieve barrier damage control

Heterogeneity characterises inflammatory diseases and different phenotypes and endotypes have been identified. Both innate and adaptive immunity contribute to the immunopathological mechanism of these diseases and barrier damage plays a prominent role triggering type 2 inflammation through the alarmins system, such as anti-Thymic Stromal Lymphopoietin (TSLP). Treatment with anti-TSLP monoclonal antibodies showed efficacy in severe asthma and clinical trials for other eosinophilic diseases are ongoing. The aim of this perspective review is to analyse current advances and future applications of TSLP inhibition to control barrier damage

COVID-19 : high-resolution computed tomography findings in the first 64 patients admitted to the Hospital of Cremona, the epicentre of the pandemic in Europe

Purpose: In December 2019, a new coronavirus (SARS-CoV-2) was identified as being responsible for the pulmonary infection called COVID-19. On 21 February 2020, the first autochthonous case of COVID-19 was detected in Italy. Our goal is to report the most common chest computed tomography (CT) findings identified in 64 patients, in the initial phase of COVID-19. Methods: Sixty-four chest high-resolution computed tomography (HRCT) examinations performed at the Radiology Unit of the Hospital of Cremona, from 22 to 29 February 2020, of 64 patients during first week of hospitalization for COVID-19 were retrospectively evaluated. All cases were confirmed by real-time RT-PCR for SARS-CoV-2. Image analysis was independently conducted by 2 radiologists with 10 years and 1 year of experience in chest imaging. The inter-observer agreement was obtained by applying a Cohen’s κ test. Results: The average age of patients was 67.1 years (± 12.2); men 42 (66%). HRCT was performed on the 5th (± 1.5) day of hospitalization. More frequently, the initial CT changes of the lung show more or less extensive areas of ground-glass, as single pattern or with parenchymal consolidations. Coronavirus lung involvement appears very frequently multi-lobar, bilateral, and it concerns both subpleural and central regions. An excellent agreement (κ: 0.88-1, CI: 0.79-1.01, p < 0.05) concerning CT findings between the 2 operators was reached. Conclusions: Our data suggest that detection of the most frequent pulmonary CT-scan changes, in the early stages of COVID-19, can be performed, with excellent agreement, among readers with different experience, and consequently attribute their exact diagnostic value, in an appropriate clinical and environmental exposure setting

energy retrofit and environmental sustainability improvement of a historical farmhouse in southern italy

Abstract This paper proposes an integrated rehabilitation project of an abandoned farmhouse in a rural area in Southern Italy. The building underwent a functional recovery to become a tourist accommodation. The use of natural materials can reduce energy consumption and carbon footprints considering environmental sustainability aspects. A proper selection of interventions targeted for the specific warm climate has led to benefits for heating, cooling and lighting in the interior spaces. The project also includes the integration of hydraulic facilities and landscaping, such as planting hedges, green barriers and native trees

Autoimmune hepatitis with eosinophilic infiltration responsive to anti-interleukin-5 receptor treatment: a case report and literature review

Inflammatory tissue damage plays a role in the onset, progression, and exacerbation of various chronic autoimmune and metabolic diseases such as autoimmune hepatitis. Here we present a case of autoimmune hepatitis with liver eosinophilic infiltrate in a severe eosinophilic asthma patient who failed conventional immunosuppressive treatment and showed improvement in gastrointestinal symptoms after anti-interleukin-5 receptor treatment. Our case highlights the potential role of eosinophils in initiating or worsening liver inflammation in autoimmune liver disease. The link between eosinophilic inflammation, barrier damage, and chronic autoimmune diseases should be considered in clinical practice

Cloud Computing and Virtual Heritage: The Social Media-Oriented Paradigm Experienced at Cineca

Dalla collaborazione di archeologi (Antonella Coralini) e tecnologi nasce questo contributo, che focalizza l'attenzione sulle potenzialit\ue0 di ricaduta sociale del Cloud Computing, con focus sul caso di studio Pompei

Energy retrofit and environmental sustainability improvement of a historical farmhouse in Southern Italy

This paper proposes an integrated rehabilitation project of an abandoned farmhouse in a rural area in Southern Italy. The building underwent a functional recovery to become a tourist accommodation. The use of natural materials can reduce energy consumption and carbon footprints considering environmental sustainability aspects. A proper selection of interventions targeted for the specific warm climate has led to benefits for heating, cooling and lighting in the interior spaces. The project also includes the integration of hydraulic facilities and landscaping, such as planting hedges, green barriers and native trees.JRC.C.2-Energy Efficiency and Renewable

Bologna porticoes project. A 3D repository for WHL UNESCO nomination

The system of Bologna porticoes, included in 2006 in the Italian tentative list of World heritage sites of UNESCO, will undergo a definitive recognition of the nomination as part of the program of the current municipal council. The nomination is aimed at highlighting the portico, not only as a high-quality architectural work, which in the past centuries has become a distinctive feature of the town, but also in its social, community and anthropological meanings, as a meeting place, a protected space. The nomination project refers to different subjects and is divided into many levels of action. Among them we are going to develop a platform conceived for on-line accessing the wealth of data and resources related to the Bolognese porticoes system, such as historical, artistic, architectural resources, besides all those data regarding its actual management. The platform will perform the harvesting of several already existing databases, making the data available to citizens, tourists and scholars thanks to a graphic interface allowing a navigation in space and time. Therefore our system will facilitate the development of further cultural and promotional cross-medial applications, such as apps for mobile devices, augmented graphics and 3D architectural mapping events. Through social media tools, citizens will be invited not only to enjoy and share the proposed contents, but also to take an active stance in the project by uploading contents and comments. The core of our platform will consist of reality-based high quality 3D models usable and navigable within the system as main user interface. Uniform quality and consistency of our reality-based 3D digital models along the more than 40 km of porticoes was ensured by a controlled, low-cost process starting from photo-modeling techniques