10 research outputs found
Regio- and Stereoselective Aminopentadienylation of Carbonyl Compounds
A simple and robust protocol is detailed for the preparation of enantioenriched α-substituted (1,4-pentadien-3-yl)amine derivatives. The methodology involves the addition of an in situ formed pentadienyl indium reagent to chiral tert-butylsulfinimines, previously formed in the same pot. The addition takes place with excellent γ-regio- and diastereoselectivity for a wide range of carbonyl compounds, including α-unsubstituted aldehydes and methyl alkyl ketones. The catalytic hydrogenation of the sulfinamines obtained provides a convenient access to chiral α-substituted (3-pentyl)amines. The hydroboration–oxidation of the α-(1,4-pentadien-3-yl)amine derivatives, followed by a cyclization under Mitsunobu conditions, takes place with an excellent diastereoselectivity governed by the chiral sulfinyl group.We thank the Spanish Ministerio de Ciencia e Innovación (CTQ2011-24165) for financial support. I.B. acknowledges the Generalitat Valenciana for a predoctoral fellowship (ACIF/2011/159). E.B. acknowledges the Council of Higher Education- Turkey for a postdoctoral fellowship (16.10.12-B.09.6.YÖK.0.71.01-207.02-12285)
Cases of active infective endocarditis in a university hospital during a 10-year period
Objective: To determine the features of patients with active infective endocarditis, and to identify causative microorganisms in blood and/or valve cultures
Synthesis of New Pyrazolothiazole Derivatives from 4-Thiazolidinones
The synthesis of new 2,3,5,6-aryl substituted tetrahydro-2H-pyrazolo[3,4-d]- thiazoles 4a-j as potential biologically active compounds by the cyclocondensation of phenyl hydrazine with new 5-arylidene derivatives 2a-j of 2,3-disubstituted-1,3- thiazolidin-4-ones 1a-e is reported
Full Paper Epibatidine Alkaloid Chemistry: 5. Domino-Heck Reactions of Azabicyclic and Tricyclic
molecule
Epibatidine Alkaloid Chemistry: 5. Domino-Heck Reactions of Azabicyclic and Tricyclic Systems
Palladium-catalyzed hydroarylations and additional domino reactions of aza- bicyclic and tricyclic norbornene derivatives were investigated and a series of new epibatidine analogues were synthesized
Regio- and Stereoselective Aminopentadienylation of Carbonyl Compounds
A simple
and robust protocol is detailed for the preparation of
enantioenriched α-substituted (1,4-pentadien-3-yl)amine derivatives.
The methodology involves the addition of an in situ formed pentadienyl
indium reagent to chiral <i>tert</i>-butylsulfinimines,
previously formed in the same pot. The addition takes place with excellent
γ-regio- and diastereoselectivity for a wide range of carbonyl
compounds, including α-unsubstituted aldehydes and methyl alkyl
ketones. The catalytic hydrogenation of the sulfinamines obtained
provides a convenient access to chiral α-substituted (3-pentyl)amines.
The hydroboration–oxidation of the α-(1,4-pentadien-3-yl)amine
derivatives, followed by a cyclization under Mitsunobu conditions,
takes place with an excellent diastereoselectivity governed by the
chiral sulfinyl group