Creación de un sistema WEB para la indexación, búsqueda y adquisición de videos mediante descriptores MPEG-7

El proyecto consiste en la creación de un sistema web capaz de indexar y buscar secuencias de video mediante descriptores MPEG-7. De esta manera se permite indexar contenido multimedia de manera automática. El usuario puede a partir del sistema web creado interactuar con una base de datos audiovisual, así como tener acceso a la búsqueda de videos basándose en una característica definida por cada descriptor MPEG-7

Galaxy And Mass Assembly (GAMA): extended intragroup light in a group at <i>z</i> = 0.2 from deep Hyper Suprime-Cam images

We present a pilot study to assess the potential of Hyper Suprime-Cam Public Data Release 2 (HSC-PDR2) images for the analysis of extended faint structures within groups of galaxies. We examine the intragroup light (IGL) of the group 400138 (Mdyn = 1.3 ± 0.5 × 1013 M⊙, z ∼ 0.2) from the Galaxy And Mass Assembly (GAMA) survey using Hyper Suprime-Cam Subaru Strategic Program Public Data Release 2 (HSC-SSP PDR2) images in g, r, and i bands. We present the most extended IGL measurement to date, reaching down to μlimg=30.76 mag arcsec−2 (3σ; 10 × 10 arcsec2) at a semimajor axis of 275 kpc. The IGL shows mean colour values of g − i = 0.92, g − r = 0.60, and r − i = 0.32 (±0.01). The IGL stellar populations are younger (2–2.5 Gyr) and less metal rich ([Fe/H] ∼ −0.4) than those of the host group galaxies. We find a range of IGL fractions as a function of total group luminosity of ∼2−36 per cent depending on the definition of IGL, with larger fractions the bluer the observation wavelength. The early-type to late-type galaxy ratio suggests that 400138 is a more evolved group, dominated by early-type galaxies, and the IGL fraction agrees with that of other similarly evolved groups. These results are consistent with tidal stripping of the outer parts of Milky Way-like galaxies as the main driver of the IGL build-up. This is supported by the detection of substructure in the IGL towards the galaxy member 1660615 suggesting a recent interaction (<1 Gyr ago) of that galaxy with the core of the group

Galaxy And Mass Assembly (GAMA): extended intragroup light in a group at z = 0.2 from deep Hyper Suprime-Cam images

We present a pilot study to assess the potential of Hyper Suprime-Cam Public Data Release 2 (HSC-PDR2) images for the analysis of extended faint structures within groups of galaxies. We examine the intragroup light (IGL) of the group 400138 (Mdyn = 1.3 ± 0.5 × 1013 M⊙, z ∼ 0.2) from the Galaxy And Mass Assembly (GAMA) survey using Hyper Suprime-Cam Subaru Strategic Program Public Data Release 2 (HSC-SSP PDR2) images in g, r, and i bands. We present the most extended IGL measurement to date, reaching down to μglim=30.76 role= presentation style= box-sizing: border-box; margin: 0px; padding: 0px; border: 0px; font-variant: inherit; font-stretch: inherit; line-height: normal; font-family: inherit; vertical-align: baseline; display: inline; word-spacing: normal; overflow-wrap: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; position: relative; \u3eμlimg=30.76μglim=30.76 mag arcsec−2 (3σ; 10 × 10 arcsec2) at a semimajor axis of 275 kpc. The IGL shows mean colour values of g − i = 0.92, g − r = 0.60, and r − i = 0.32 (±0.01). The IGL stellar populations are younger (2–2.5 Gyr) and less metal rich ([Fe/H] ∼ −0.4) than those of the host group galaxies. We find a range of IGL fractions as a function of total group luminosity of ∼2−36 per cent role= presentation style= box-sizing: border-box; margin: 0px; padding: 0px; border: 0px; font-variant: inherit; font-stretch: inherit; line-height: normal; font-family: inherit; vertical-align: baseline; display: inline; word-spacing: normal; overflow-wrap: normal; white-space: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; position: relative; \u3e∼2−36 per cent∼2−36 per cent depending on the definition of IGL, with larger fractions the bluer the observation wavelength. The early-type to late-type galaxy ratio suggests that 400138 is a more evolved group, dominated by early-type galaxies, and the IGL fraction agrees with that of other similarly evolved groups. These results are consistent with tidal stripping of the outer parts of Milky Way-like galaxies as the main driver of the IGL build-up. This is supported by the detection of substructure in the IGL towards the galaxy member 1660615 suggesting a recent interaction (\u3c1 Gyr ago) of that galaxy with the core of the group

Selective suppression of α-Synuclein in monoaminergic neurons of mice by intranasal delivery of targeted small interfering RNA or antisense oligonucleotides: Potential therapy for Parkinson's disease

Póster presentado en: ACNP (American College of Neuropsychopharmacology) 52nd Annual Conference, celebrada del 8 al 12 de diciembre de 2013 en Hollywood, Florida (Estados Unidos)Abstract publicado en: Neuropsychopharmacology 38:S419-S420 (2013). ISSN: 0893-133X. eISSN: 1740-634X. DOI:10.1038/npp.2013.280α-Synuclein (α-Syn) appears to play a crucial role in the pathogenesis of several neurodegenerative disorders including Parkinson's disease (PD). The brains of Parkinson patients typically contain insoluble intracellular protein inclusions called Lewy bodies. Increased neuronal α-Syn levels represent a major component of Lewy bodies and therefore, the suppression of α-Syn expression provides a valid therapeutic target for PD. The goal of this study was to assess the ability of various small interfering RNA (siRNA) and antisense oligonucleotide (ASO) sequences directed against α-Syn to downregulate endogenous or overexpressed α-Syn mRNA levels in BE-M17 neuroblastoma cells. Moreover, we evaluated the feasibility of reducing α-Syn expression selectively in PD-vulnerable brain areas including substantia nigra pars compacta (SNc), ventral tegmental area (VTA), locus coeruleus (LC) and dorsal raphe nucleus (DR) of mice after the internalization of conjugated siRNA/ASO molecules into monoamine neurons following intranasal administration. Conclusions: These results set the stage for the testing of these molecules as potential disease-modifying agents in neurotoxin-based and genetic models of PD linked to pathogenic increases in α-Syn. In this study we have characterized conjugated siRNA and ASO molecules that actively reduce endogenous α-Syn expression in vivo using the intranasal route to deliver directly siRNA/ASO into the brainPeer Reviewe

Can an emblematic species become a pest? The case of Astrospartus mediterraneus (Risso, 1826) (Echinodermata: Ophiuroidea) in the artisanal fishing grounds of the Cap de Creus area (NW Mediterranean Sea)

4th Mediterranean Symposium on the Conservation of Coralligenous & other Calcareous Bio-Concretions, 20-21 September 2022, Genoa, Italy.-- 6 pages, 2 figuresAstrospartus mediterraneus (Risso, 1826) (Echinodermata: Ophiuroidea) is an emblematic Mediterranean species yet, it has few reports and hasn’t received much attention from the marine scientific community to date. In the framework of a project to assess how to mitigate the impact of artisanal fishing on benthic communities at the Site of Community Importance (SCI) of Cap de Creus (NW Mediterranean) (MITICAP Project), an unusually high abundance of the basket star (A. mediterraneus) was observed in 2018 as part of the by-catch of the local artisanal fishers. Indeed, the fishers involved in the project reported that this species had increased in abundance and expanded its distribution over the past years, ultimately interfering with their fishing activity. This work benefits from the Local Ecological Knowledge of the fishers, analyses field surveys and aims to elucidate the abundance, distribution, size, and structure of A. mediterraneus populations; as well as to examine the possible impact this species has on the artisanal fisheries performance. Data collection was performed through bycatch photo analysis of regular fishing events from May to August, analysis of video-transects recorded by means of Remote Operated Vehicles and conducting interviews with fishers to identify the impact. Basket stars were associated with rocky substrates with presence of gorgonians located between 50 to 80 m depth, preferentially occurring on sloping areas. Despite their high abundances (0.45±0.71 ind/m2), the aggregations witnessed in the Cap de Creus area could not be determined as an outbreak due to the lack of longtime monitoring data thus, yet it seems apparent based on the LEK of the fishers that the species has been on the rise for the past years and they unanimously consider that its proliferation causes them a handicap in terms of monetary and time lossesTheir work was performed under the MitiCap and ResCap projects, which are founded by the Fundación Biodiversidad from the Ministerio para la Transición Ecológica, through the Pleamar Program, co-funded by the European Maritime and Fisheries FundPeer reviewe

Genomics improves risk stratifi cation of adults with T-cell acute lymphoblastic leukemia enrolled in measurable residual disease-oriented trials

Genetic information has been crucial to understand the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) at diagnosis and at relapse, but still nowadays has a limited value in a clinical context. Few genetic markers are associated with the outcome of T-ALL patients, independently of measurable residual disease (MRD) status after therapy. In addition, the prognostic relevance of genetic features may be modulated by the specific treatment used. We analyzed the genetic profile of 145 T-ALL patients by targeted deep sequencing. Genomic information was integrated with the clinical -biological and survival data of a subset of 116 adult patients enrolled in two consecutive MRD-oriented trials of the Spanish PETHEMA (Programa Espanol de Tratamientos en Hematologia) group. Genetic analysis revealed a mutational profile defined by DNMT3A/ N/KRAS/ MSH2/ U2AF1 gene mutations that identified refractory/resistant patients. Mutations in the DMNT3A gene were also found in the non-leukemic cell fraction of patients with T-ALL, revealing a possible mutational-driven clonal hematopoiesis event to prime T-ALL in elderly. The prognostic impact of this adverse genetic profile was independent of MRD status on day +35 of induction therapy. The combined worse-outcome genetic signature and MRD on day +35 allowed risk stratification of T-ALL into standard or high-risk groups with significantly different 5 -year overall survival (OS) of 52% (95% confidence interval: 37-67) and 17% (95% confidence interval: 1-33), respectively. These results confirm the relevance of the tumor genetic profile in predicting patient outcome in adult T-ALL and highlight the need for novel gene-targeted chemotherapeutic schedules to improve the OS of poor-prognosis T-ALL patients

Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections

IMPORTANCE The consumption of broad-spectrum drugs has increased as a consequence of the spread of multidrug-resistant (MDR) Escherichia coli. Finding alternatives for these infections is critical, for which some neglected drugs may be an option. OBJECTIVE To determine whether fosfomycin is noninferior to ceftriaxone or meropenem in the targeted treatment of bacteremic urinary tract infections (bUTIs) due to MDR E coli. DESIGN, SETTING, AND PARTICIPANTS This multicenter, randomized, pragmatic, open clinical trial was conducted at 22 Spanish hospitals from June 2014 to December 2018. Eligible participants were adult patients with bacteremic urinary tract infections due to MDR E coli; 161 of 1578 screened patients were randomized and followed up for 60 days. Data were analyzed in May 2021. INTERVENTIONS Patients were randomized 1 to 1 to receive intravenous fosfomycin disodium at 4 g every 6 hours (70 participants) or a comparator (ceftriaxone or meropenem if resistant; 73 participants) with the option to switch to oral fosfomycin trometamol for the fosfomycin group or an active oral drug or pa renteral ertapenem for the comparator group after 4 days. MAIN OUTCOMES AND MEASURES The primary outcome was clinical and microbiological cure (CMC) 5 to 7 days after finalization of treatment; a noninferiority margin of 7% was considered. RESULTS Among 143 patients in the modified intention-to-treat population (median [IQR] age, 72 [62-81] years; 73 [51.0%] women), 48 of 70 patients (68.6%) treated with fosfomycin and 57 of 73 patients (78.1%) treated with comparators reached CMC (risk difference, -9.4 percentage points; 1-sided 95% CI, -21.5 to infinity percentage points; P = .10). While clinical or microbiological failure occurred among 10 patients (14.3%) treated with fosfomycin and 14 patients (19.7%) treated with comparators (risk difference, -5.4 percentage points; 1-sided 95% CI. -infinity to 4.9; percentage points; P = .19), an increased rate of adverse event-related discontinuations occurred with fosfomycin vs comparators (6 discontinuations [8.5%] vs 0 discontinuations; P = .006). In an exploratory analysis among a subset of 38 patients who underwent rectal colonization studies, patients treated with fosfomycin acquired a new ceftriaxone-resistant or meropenem-resistant gram-negative bacteria at a decreased rate compared with patients treated with comparators (0 of 21 patients vs 4 of 17 patients [23.5%]; 1-sided P = .01). CONCLUSIONS AND RELEVANCE This study found that fosfomycin did not demonstrate noninferiority to comparators as targeted treatment of bUTI from MDR E coli; this was due to an increased rate of adverse event-related discontinuations. This finding suggests that fosfomycin may be considered for selected patients with these infections

Systematic Collaborative Reanalysis of Genomic Data Improves Diagnostic Yield in Neurologic Rare Diseases

Altres ajuts: Generalitat de Catalunya, Departament de Salut; Generalitat de Catalunya, Departament d'Empresa i Coneixement i CERCA Program; Ministerio de Ciencia e Innovación; Instituto Nacional de Bioinformática; ELIXIR Implementation Studies (CNAG-CRG); Centro de Investigaciones Biomédicas en Red de Enfermedades Raras; Centro de Excelencia Severo Ochoa; European Regional Development Fund (FEDER).Many patients experiencing a rare disease remain undiagnosed even after genomic testing. Reanalysis of existing genomic data has shown to increase diagnostic yield, although there are few systematic and comprehensive reanalysis efforts that enable collaborative interpretation and future reinterpretation. The Undiagnosed Rare Disease Program of Catalonia project collated previously inconclusive good quality genomic data (panels, exomes, and genomes) and standardized phenotypic profiles from 323 families (543 individuals) with a neurologic rare disease. The data were reanalyzed systematically to identify relatedness, runs of homozygosity, consanguinity, single-nucleotide variants, insertions and deletions, and copy number variants. Data were shared and collaboratively interpreted within the consortium through a customized Genome-Phenome Analysis Platform, which also enables future data reinterpretation. Reanalysis of existing genomic data provided a diagnosis for 20.7% of the patients, including 1.8% diagnosed after the generation of additional genomic data to identify a second pathogenic heterozygous variant. Diagnostic rate was significantly higher for family-based exome/genome reanalysis compared with singleton panels. Most new diagnoses were attributable to recent gene-disease associations (50.8%), additional or improved bioinformatic analysis (19.7%), and standardized phenotyping data integrated within the Undiagnosed Rare Disease Program of Catalonia Genome-Phenome Analysis Platform functionalities (18%)

Creación de un sistema WEB para la indexación, búsqueda y adquisición de videos mediante descriptores MPEG-7

El proyecto consiste en la creación de un sistema web capaz de indexar y buscar secuencias de video mediante descriptores MPEG-7. De esta manera se permite indexar contenido multimedia de manera automática. El usuario puede a partir del sistema web creado interactuar con una base de datos audiovisual, así como tener acceso a la búsqueda de videos basándose en una característica definida por cada descriptor MPEG-7

Creación de un sistema WEB para la indexación, búsqueda y adquisición de videos mediante descriptores MPEG-7

El proyecto consiste en la creación de un sistema web capaz de indexar ybuscar secuencias de video mediante descriptores MPEG-7. De esta manerase permite indexar contenido multimedia de manera automática. El usuariopuede a partir del sistema web creado interactuar con una base de datosaudiovisual, así como tener acceso a la búsqueda de videos basándose enuna característica definida por cada descriptor MPEG-7