18 research outputs found
FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF AMLODIPINE BESYLATE
Objective: The main objective of this research work was to formulate and evaluate the mouth dissolving tablet of amlodipine besylate for the treatment of hypertension and coronary artery disease.
Methods: In this study, mouth dissolving tablet were prepared by direct compression method by using croscarmellose sodium and sodium starch glycolate as superdisintegrants. The designed tablets were subjected to various assessment parameters like friability test, hardness test, disintegration test, wetting time, in vitro drug release and drug content.
Results: All the prepared formulations were subjected to various assessment parameters, and the findings obtain within the prescribed limit. The calibration curve of pure drug using various solvents like phosphate buffer pH 6.8, methanol was plotted. F1-F9 containing croscarmellose sodium and sodium starch glycolate in various concentration demonstrate the minimum disintegration time. Among all these formulations F9 shows disintegration time up to 22±1.12 seconds due to the high concentration of superdisintegrants. In vitro drug release was tested in phosphate buffer pH 6.8 at a time interval of 0, 1, 2, 3, 4, 5 min. The F9 shows drug release 100.22±1.08%. Accelerated stability study of optimized formulation (F9) up to 2 mo showed there was no change in disintegration time and percentage drug release.
Conclusion: The results obtained in the research work clearly showed a promising potential of mouth dissolving tablets containing a specific ratio of croscarmellose sodium and sodium starch glycolate as superdisintegrants for the effective treatment of hypertension and coronary artery disease
Threshold meson production and cosmic ray transport
An interesting accident of nature is that the peak of the cosmic ray
spectrum, for both protons and heavier nuclei, occurs near the pion production
threshold. The Boltzmann transport equation contains a term which is the cosmic
ray flux multiplied by the cross section. Therefore when considering pion and
kaon production from proton-proton reactions, small cross sections at low
energy can be as important as larger cross sections at higher energy. This is
also true for subthreshold kaon production in nuclear collisions, but not for
subthreshold pion production.Comment: 9 pages, 1 figur
Galactic diffusion and the antiprotron signal of supersymmetric dark matter
The leaky box model is now ruled out by measurements of a cosmic ray gradient
throughout the galactic disk. It needs to be replaced by a more refined
treatment which takes into account the diffusion of cosmic rays in the magnetic
fields of the Galaxy. We have estimated the flux of antiprotons on the Earth in
the framework of a two-zone diffusion model. Those species are created by the
spallation reactions of high-energy nuclei with the interstellar gas. Another
potential source of antiprotons is the annihilation of supersymmetric particles
in the dark halo that surrounds our Galaxy. In this letter, we investigate both
processes. Special emphasis is given to the antiproton signature of
supersymmetric dark matter. The corresponding signal exceeds the conventional
spallation flux below 300 MeV, a domain that will be thoroughly explored by the
Antimatter Spectrometer experiment. The propagation of the antiprotons produced
in the remote regions of the halo back to the Earth plays a crucial role.
Depending on the energy, the leaky box estimates are wrong by a factor varying
from 0.5 up to 3.Comment: 14 pages, LaTeX, 4 postscript figures appended as uuencoded g-zipped
tar fil
Quantitative proteomics of Alzheimer's-like cerebral vasculature in TGF- f1 overexpressing mice and its perturbation by pioglitazone
Elevation of transforming growth factor-beta 1 (TGF\u3b21), a key extracellular matrix regulator, has been documented in the brain and cerebral vasculature of Alzheimer's disease (AD) patients. Transgenic mice overexpressing TGF\u3b21 in the brain (TGF mice) develop AD-like vascular structural changes, impaired vasomotricity, and compromised neurovascular coupling. We have demonstrated that cerebrovascular dysfunction in both aged and young TGF mice is normalized by the peroxisome proliferator-activated receptor-\u3b3 agonist pioglitazone. Our aims are to (a) characterize the cerebrovascular proteome of TGF mice and its perturbation by pioglitazone using label-free mass spectrometry-based quantitative proteomics, and (b) identify proteins that orchestrate pioglitazone-mediated recovery of cerebrovascular function.Peer reviewed: YesNRC publication: Ye
Excitation functions of proton-induced reactions on
Excitation functions of proton-induced reactions for the natural iron and zirconium targets were measured from their respective threshold energies to 22 and 20 MeV. The conventional stacked foil technique was used in combination with the off-line -ray spectroscopy at the BARC-TIFR Pelletron facility, Mumbai. The computer code SRIM 2013 was used to calculate the energy degradation along the stack and the proton beam intensity was measured via the natCu(p,x)62Zn monitor reaction. The measured excitation functions were then compared with the literature data available in EXFOR database as well as with the theoretical values from the TALYS-1.8 code and the TENDL-2017 data library. The shapes of the excitation function for all the reactions were reproduced well by TALYS-1.8. In terms of absolute values, for some reactions the data are in good agreement with both the literature data and TALYS-1.8 whereas, for others there is a slight deviation either from the literature data or from the theoretical values of TALYS-1.8 and TENDL-2017
Label-free quantitative proteomics of surgically isolated brain vessels from Alzheimer's mice to study the effect of Pioglitazone.
Peer reviewed: YesNRC publication: Ye
Measurement of
The reaction cross sections relative to
monitor reaction with the neutron energies of 0.61 and 1.05 MeV from the 7Li(p,n)7Be reaction have been measured for the first time by using the activation and off-line -ray spectrometric technique. The error analysis of the experimental data was done by considering the partial uncertainties in various attributes and the correlations between those attributes were reported through covariance analysis. The present experimental cross sections have been compared with the theoretical prediction by TALYS-1.8 using the back-shifted Fermi gas model and Brink-Axel Lorentzian -ray strength functions. The TALYS-1.8 calculations well predicted the present experimental cross sections at both neutron energies. The spectrum averaged neutron capture cross sections of 96Zr obtained in the present work have also been compared with the evaluated cross sections from ENDF/B-VIII.0, JENDL-4, JEFF-3.3, CENDL-3.1 and TENDL-2015 libraries. They are found to be in close agreement with the TENDL-2015 and CENDL-3.1 libraries at the neutron energies of 0.61 and 1.05 MeV
Space Radiation: The Number One Risk to Astronaut Health beyond Low Earth Orbit
Projecting a vision for space radiobiological research necessitates understanding the nature of the space radiation environment and how radiation risks influence mission planning, timelines and operational decisions. Exposure to space radiation increases the risks of astronauts developing cancer, experiencing central nervous system (CNS) decrements, exhibiting degenerative tissue effects or developing acute radiation syndrome. One or more of these deleterious health effects could develop during future multi-year space exploration missions beyond low Earth orbit (LEO). Shielding is an effective countermeasure against solar particle events (SPEs), but is ineffective in protecting crew members from the biological impacts of fast moving, highly-charged galactic cosmic radiation (GCR) nuclei. Astronauts traveling on a protracted voyage to Mars may be exposed to SPE radiation events, overlaid on a more predictable flux of GCR. Therefore, ground-based research studies employing model organisms seeking to accurately mimic the biological effects of the space radiation environment must concatenate exposures to both proton and heavy ion sources. New techniques in genomics, proteomics, metabolomics and other “omics” areas should also be intelligently employed and correlated with phenotypic observations. This approach will more precisely elucidate the effects of space radiation on human physiology and aid in developing personalized radiological countermeasures for astronauts