Strong tip-sample coupling in thermal radiation scanning tunneling microscopy

We analyze how a probing particle modifies the infrared electromagnetic near field of a sample. The particle, described by electric and magnetic polarizabilities, represents the tip of an apertureless scanning optical near-field microscope (SNOM). We show that the interaction with the sample can be accounted for by ascribing to the particle dressed polarizabilities that combine the effects of image dipoles with retardation. When calculated from these polarizabilities, the SNOM signal depends only on the fields without the perturbing tip. If the studied surface is not illuminated by an external source but heated instead, the signal is closely related to the projected electromagnetic local density of states (EM-LDOS). Our calculations provide the link between the measured far-field spectra and the sample's optical properties.We also analyze the case where the probing particle is hotter than the sample and evaluate the impact of the dressed polarizabilities on near-field radiative heat transfer. We show that such a heated probe above a surface performs a surface spectroscopy, in the sense that the spectrum of the heat current is closely related to the local electromagnetic density of states. The calculations agree well with available experimental data.Comment: Soumis \`a JQSRT. arXiv admin note: substantial text overlap with arXiv:1201.483

SCN5A mutations and the role of genetic background in the pathophysiology of Brugada syndrome.

International audienceBACKGROUND: Mutations in SCN5A are identified in approximately 20% to 30% of probands affected by Brugada syndrome (BrS). However, in familial studies, the relationship between SCN5A mutations and BrS remains poorly understood. The aim of this study was to investigate the association of SCN5A mutations and BrS in a group of large genotyped families. METHODS AND RESULTS: Families were included if at least 5 family members were carriers of the SCN5A mutation, which was identified in the proband. Thirteen large families composed of 115 mutation carriers were studied. The signature type I ECG was present in 54 mutation carriers (BrS-ECG+; 47%). In 5 families, we found 8 individuals affected by BrS but with a negative genotype (mutation-negative BrS-ECG+). Among these 8 mutation-negative BrS-ECG+ individuals, 3, belonging to 3 different families, had a spontaneous type I ECG, whereas 5 had a type I ECG only after the administration of sodium channel blockers. One of these 8 individuals had also experienced syncope. Mutation carriers had, on average, longer PR and QRS intervals than noncarriers, demonstrating that these mutations exerted functional effects. CONCLUSIONS: Our results suggest that SCN5A mutations are not directly causal to the occurrence of a BrS-ECG+ and that genetic background may play a powerful role in the pathophysiology of BrS. These findings add further complexity to concepts regarding the causes of BrS, and are consistent with the emerging notion that the pathophysiology of BrS includes various elements beyond mutant sodium channels

Impact of clinical and genetic findings on the management of young patients with Brugada syndrome.

BACKGROUND: Brugada syndrome (BrS) is an arrhythmogenic disease associated with sudden cardiac death (SCD) that seldom manifests or is recognized in childhood. OBJECTIVES: The objectives of this study were to describe the clinical presentation of pediatric BrS to identify prognostic factors for risk stratification and to propose a data-based approach management. METHODS: We studied 106 patients younger than 19 years at diagnosis of BrS enrolled from 16 European hospitals. RESULTS: At diagnosis, BrS was spontaneous (n = 36, 34%) or drug-induced (n = 70, 66%). The mean age was 11.1 ± 5.7 years, and most patients were asymptomatic (family screening, (n = 67, 63%; incidental, n = 13, 12%), while 15 (14%) experienced syncope, 6(6%) aborted SCD or symptomatic ventricular tachycardia, and 5 (5%) other symptoms. During follow-up (median 54 months), 10 (9%) patients had life-threatening arrhythmias (LTA), including 3 (3%) deaths. Six (6%) experienced syncope and 4 (4%) supraventricular tachycardia. Fever triggered 27% of LTA events. An implantable cardioverter-defibrillator was implanted in 22 (21%), with major adverse events in 41%. Of the 11 (10%) patients treated with hydroquinidine, 8 remained asymptomatic. Genetic testing was performed in 75 (71%) patients, and SCN5A rare variants were identified in 58 (55%); 15 of 32 tested probands (47%) were genotype positive. Nine of 10 patients with LTA underwent genetic testing, and all were genotype positive, whereas the 17 SCN5A-negative patients remained asymptomatic. Spontaneous Brugada type 1 electrocardiographic (ECG) pattern (P = .005) and symptoms at diagnosis (P = .001) were predictors of LTA. Time to the first LTA event was shorter in patients with both symptoms at diagnosis and spontaneous Brugada type 1 ECG pattern (P = .006). CONCLUSION: Spontaneous Brugada type 1 ECG pattern and symptoms at diagnosis are predictors of LTA events in the young affected by BrS. The management of BrS should become age-specific, and prevention of SCD may involve genetic testing and aggressive use of antipyretics and quinidine, with risk-specific consideration for the implantable cardioverter-defibrillator

Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility.

Brugada syndrome (BrS) is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of SCN5A, encoding the cardiac sodium channel Na1.5, susceptibility genes remain largely unknown. Here we performed a genome-wide association meta-analysis comprising 2,820 unrelated cases with BrS and 10,001 controls, and identified 21 association signals at 12 loci (10 new). Single nucleotide polymorphism (SNP)-heritability estimates indicate a strong polygenic influence. Polygenic risk score analyses based on the 21 susceptibility variants demonstrate varying cumulative contribution of common risk alleles among different patient subgroups, as well as genetic associations with cardiac electrical traits and disorders in the general population. The predominance of cardiac transcription factor loci indicates that transcriptional regulation is a key feature of BrS pathogenesis. Furthermore, functional studies conducted on MAPRE2, encoding the microtubule plus-end binding protein EB2, point to microtubule-related trafficking effects on Na1.5 expression as a new underlying molecular mechanism. Taken together, these findings broaden our understanding of the genetic architecture of BrS and provide new insights into its molecular underpinnings

Étude en champ proche optique de sources plasmoniques actives dans l'infrarouge et spectroscopie locale de l'émission thermique

Nous présentons l'étude en microscopie optique en champ proche à pointe diffusante (a-SNOM) de lasers à cascade quantique (QCLs) spécialement conçus pour la génération électrique de plasmons-polaritons de surface (SPPs) dans le moyen infrarouge. Ces derniers sont générés soit en structurant la surface du ruban du QCL avec un réseau métallique en or, soit par couplage direct à la sortie de la facette du laser avec une piste métallique. Lorsque cette piste est périodiquement structurée, nous montrons qu'il est possible de conférer aux SPPs du moyen infrarouge des propriétés de confinement semblable à celles des SPPs du visible. La structuration de l'extrémité du réseau sous la forme d'une pointe nous a aussi permis de mettre en évidence la concentration de l'énergie des SPPs sur un point chaud de taille sub-longueur d'onde. Nous présentons aussi la spectroscopie de l'émission thermique en champ proche réalisée en couplant un a-SNOM, fonctionnant sans illumination externe, avec un spectromètre à transformée de Fourier (FTIR). En investiguant des matériaux polaires présentant des modes de surface appelés phonons-polaritons de surface, nous avons mesuré leurs spectres caractérisés en champ proche par un pic monochromatique. Ce résultat constitue la première démonstration expérimentale de la cohérence temporelle de l'émission thermique en champ proche. Nous montrons sur base d'un modèle théorique développé par nos collaborateurs, que nous mesurons les variations spectrales de la densité locale de modes optiques (LDOS). Ce nouvel instrument nous a permis de développer un nouveau mode de spectroscopie infrarouge résolue spatialement à une échelle sub-longueur d'onde.PARIS-BIUSJ-Biologie recherche (751052107) / SudocSudocFranceF

Near-field thermal radiation scattered by a dipolar tip above a material

PresentationInternational audienc

Near-field thermal signal detected by a dipolar tip

PresentationInternational audienc

Near-field thermal signal detected by a dipolar tip

Invited talk by K. JoulainPhonons and Fluctuations III, Sant Feliu de Guixols (Spain), May 21st-24th, 2012, Invited talk by K. Joulai