Helping to Support CPC+ Initiative to Integrate Behavioral Health Within Primary Care: A Team-Based Approach to Improving Depression Management

AIM: The objective of this project is to increase the rate of documented successful treatment of depression for both new and established diagnoses of depression at Jefferson Internal Medicine Associates (JIMA) from 29% to 50% over 12 months.https://jdc.jefferson.edu/patientsafetyposters/1027/thumbnail.jp

A depolarization and attenuation experiment using the COMSTAR and CTS satellites

Monthly and annual percent-of-time data on ground rain fall rate and attenuation on satellite downlinks at 11.7 GHz, 19.04 GHz, and 28.56 GHz is presented. Equal probability values of attenuation and rain rate are compared for monthly, quarterly, half-year periods and for the entire year. Regression equations relating cross polarization isolation to the logarithm of attenuation are also presented

Is Nitric Oxide Decrease Observed with Naphthoquinones in LPS Stimulated RAW 264.7 Macrophages a Beneficial Property?

The search of new anti-inflammatory drugs has been a current preoccupation, due to the need of effective drugs, with less adverse reactions than those used nowadays. Several naphthoquinones (plumbagin, naphthazarin, juglone, menadione, diosquinone and 1,4-naphthoquinone), plus p-hydroquinone and p-benzoquinone were evaluated for their ability to cause a reduction of nitric oxide (NO) production, when RAW 264.7 macrophages were stimulated with lipopolysaccharide (LPS). Dexamethasone was used as positive control. Among the tested compounds, diosquinone was the only one that caused a NO reduction with statistical importance and without cytotoxicity: an IC25 of 1.09±0.24 µM was found, with 38.25±6.50% (p<0.001) NO reduction at 1.5 µM. In order to elucidate if this NO decrease resulted from the interference of diosquinone with cellular defence mechanisms against LPS or to its conversion into peroxynitrite, by reaction with superoxide radical formed by naphthoquinones redox cycling, 3-nitrotyrosine and superoxide determination was also performed. None of these parameters showed significant changes relative to control. Furthermore, diosquinone caused a decrease in the pro-inflammatory cytokines: tumour necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6). Therefore, according to the results obtained, diosquinone, studied for its anti-inflammatory potential for the first time herein, has beneficial effects in inflammation control. This study enlightens the mechanisms of action of naphthoquinones in inflammatory models, by checking for the first time the contribution of oxidative stress generated by naphthoquinones to NO reduction

A physical map of Brassica oleracea shows complexity of chromosomal changes following recursive paleopolyploidizations

<p>Abstract</p> <p>Background</p> <p>Evolution of the Brassica species has been recursively affected by polyploidy events, and comparison to their relative, <it>Arabidopsis thaliana</it>, provides means to explore their genomic complexity.</p> <p>Results</p> <p>A genome-wide physical map of a rapid-cycling strain of <it>B. oleracea </it>was constructed by integrating high-information-content fingerprinting (HICF) of Bacterial Artificial Chromosome (BAC) clones with hybridization to sequence-tagged probes. Using 2907 contigs of two or more BACs, we performed several lines of comparative genomic analysis. Interspecific DNA synteny is much better preserved in euchromatin than heterochromatin, showing the qualitative difference in evolution of these respective genomic domains. About 67% of contigs can be aligned to the Arabidopsis genome, with 96.5% corresponding to euchromatic regions, and 3.5% (shown to contain repetitive sequences) to pericentromeric regions. Overgo probe hybridization data showed that contigs aligned to Arabidopsis euchromatin contain ~80% of low-copy-number genes, while genes with high copy number are much more frequently associated with pericentromeric regions. We identified 39 interchromosomal breakpoints during the diversification of <it>B. oleracea </it>and <it>Arabidopsis thaliana</it>, a relatively high level of genomic change since their divergence. Comparison of the <it>B. oleracea </it>physical map with Arabidopsis and other available eudicot genomes showed appreciable 'shadowing' produced by more ancient polyploidies, resulting in a web of relatedness among contigs which increased genomic complexity.</p> <p>Conclusions</p> <p>A high-resolution genetically-anchored physical map sheds light on Brassica genome organization and advances positional cloning of specific genes, and may help to validate genome sequence assembly and alignment to chromosomes.</p> <p>All the physical mapping data is freely shared at a WebFPC site (<url>http://lulu.pgml.uga.edu/fpc/WebAGCoL/brassica/WebFPC/</url>; Temporarily password-protected: account: pgml; password: 123qwe123.</p

Host genetic signatures of susceptibility to fungal disease

Our relative inability to predict the development of fungal disease and its clinical outcome raises fundamental questions about its actual pathogenesis. Several clinical risk factors are described to predispose to fungal disease, particularly in immunocompromised and severely ill patients. However, these alone do not entirely explain why, under comparable clinical conditions, only some patients develop infection. Recent clinical and epidemiological studies have reported an expanding number of monogenic defects and common polymorphisms associated with fungal disease. By directly implicating genetic variation in the functional regulation of immune mediators and interacting pathways, these studies have provided critical insights into the human immunobiology of fungal disease. Most of the common genetic defects reported were described or suggested to impair fungal recognition by the innate immune system. Here, we review common genetic variation in pattern recognition receptors and its impact on the immune response against the two major fungal pathogens Candida albicans and Aspergillus fumigatus. In addition, we discuss potential strategies and opportunities for the clinical translation of genetic information in the field of medical mycology. These approaches are expected to transfigure current clinical practice by unleashing an unprecedented ability to personalize prophylaxis, therapy and monitoring for fungal disease.This work was supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) (NORTE-01-0145-FEDER-000013), the Fundação para a Ciência e Tecnologia (FCT) (IF/00735/2014 to AC, and SFRH/BPD/96176/2013 to CC), the Institut Mérieux (Mérieux Research Grant 2017 to CC), and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID Research Grant 2017 to AC)

Selected aspects of ecological vehicles

W artykule przedstawiono problematykę samochodów ekologicznych. Przeglądowo scharakteryzowano specyfikę samochodów o napędzie elektrycznym, zastosowanie energii słońca w samochodach, pojazdy hybrydowe oraz samochody zasilane wodorem. Omówiono również prognozy rozwoju samochodów ekologicznych, aspekty ekonomiczne oraz akcje promujące ich sprzedaż.The paper presents the problem of ecological cars. Characterized the specificity of electric cars, the use of solar energy in cars, hybrid vehicles and vehicles powered by hydrogen. It also discusses the development of green cars forecasts, economic aspects and actions to promote their sale

Nowe rozwiązanie konstrukcji jednostki chłodzącej do zastosowania w produkcji części lotniczych

Continuous development in aerospace industry puts increasingly higher challenges for manufacturers of aerospace parts. The production process of aerospace parts must meet strict requirements. One of them is inspection of part’s dimensions at the various stages of its production. It is important to proceed with the measurements when the part reaches desired temperature (usually 20°C). Temperature of the parts after machining process may be raised to approx. 60°C, hence they need to be cooled down. Cooling requires especially long time in case of large volume parts, which leads to prolongation of their delivery time. The research and development work in this field is therefore focused mainly on developing new solutions which may accelerate the cooling process. The present study describes the influence of temperature of workpiece on the result of dimensions measurement and a new design of refrigerator developed and patented by WALDREX Sp. z o.o. Refrigerator is equipped with an insulated container with cooling coil. The container is fixed in a stainless-steel frame. Provided solution enables fast and cost-effective cooling and keeping workpieces at a given temperature.Rozwój lotnictwa stawia coraz większe wyzwania dla producentów części lotniczych. Wytwarzanie tych części jest związane z koniecznością spełnienia rygorystycznych wymagań przez zakłady produkcyjne. Jednym z nich jest prowadzenie kontroli wymiarów detalu w poszczególnych etapach jego produkcji. Istotne w tym przypadku jest wykonywanie pomiarów w ustalonej temperaturze (zwykle 20°C). Elementy wytwarzane w procesach obróbki skrawaniem po jej wykonaniu mogą mieć temperaturę podwyższoną do ok. 60°C. Chłodzenie elementów o dużej objętości jest długotrwałe i zwiększa czas ich produkcji. Stąd prowadzone są prace badawczo-rozwojowe mające na celu opracowanie nowych rozwiązań przyspieszających chłodzenie detali. W pracy analizowano wpływ wartości temperatury detalu na wyniki pomiarów oraz przedstawiono nowe rozwiązanie konstrukcji chłodziarki opracowane i opatentowane w ramach prac prowadzonych przez przedsiębiorstwo WALDREX Sp. z o.o. Konstrukcja jest wyposażona w izolowany pojemnik osadzony w ramie ze stali odpornej na korozję, w którym znajduje się wężownica oraz ciecz chłodząca, co umożliwia szybkie i ekonomiczne chłodzenie detali i utrzymywanie ich w określonej temperaturze

Elevating the Role of the Medical Assistant through a Team-Based Training Curriculum

The current role of medical assistants within our primary care clinics is limited. The vast majority of tasks fall to the providers, despite the availability of other team members who may be better suited to the task. We are currently using a Team-Based Training Curriculum, modeled after the Safety Net Medical Home Initiative and AHRQ\u27s TeamSTEPPS in Primary Care to train our medical assistants in team-based care, quality improvement and standardization. The goal of the curriculum is to empower other team members to work at the top of their license, on such tasks as pre-visit planning, gap analysis and chronic disease management. Objectives: After participating in this session or reviewing the poster, participants should be able to: 1. Critically examine the roles of various team members in their own healthcare setting. 2. Identify areas of improvement within their team structure. 3. Compare available curricular materials that can be used to lead change within their healthcare setting. Presentation: 49 minute