Upregulating Positive Affectivity in the Transdiagnostic Treatment of Emotional Disorders: A Randomized Pilot Study

Transdiagnostic cognitive-behavioral therapy for emotional disorders (ED) has proven to be effective. However, current transdiagnostic treatment protocols address only the regulation of negative affectivity, and they do not include treatment components to more directly target the regulation of positive affectivity. In this study, we propose to evaluate the preliminary efficacy and acceptability of a transdiagnostic treatment protocol for ED that includes, as an innovative feature, a specific treatment component to directly upregulate positive affectivity based on positive psychology interventions. A total of 24 participants were randomized to either a transdiagnostic treatment protocol (n = 12) or a transdiagnostic treatment protocol with an additional component designed to regulate positive affectivity (n = 12). Participants completed measures of anxiety, depression, positive and negative affectivity, and quality of life, as well as treatment acceptability at pre- and posttreatment and at the 3-month follow-up. Both interventions led to improvements in all measures at posttreatment, and these outcomes were maintained at the 3-month follow-up, with large effect sizes for all measures. The effect sizes for positive affect were larger in the condition that included the component to upregulate positive affectivity. Attrition rate was low, and both treatment protocols were well accepted by participants. The results obtained in this study indicate the feasibility of testing the treatment protocol in a larger, randomized, controlled trial, and they suggest the potential of including treatment components for directly upregulating positive affectivity in future research on transdiagnostic treatment protocols for ED

Analysis of the massive MIMO indoor channel for its applications in 5G

Grado en Ingeniería de Tecnologías de Telecomunicació

Personal Anonycloud

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PTS and PTSO, two organosulfur compounds from onion by‑products as a novel solution for plant disease and pest management

This research has been carried out within the project GRUPO OPERATIVO SALUD-OLIVAR from the Spanish Rural Development Program (2014-2020) funded by the Spanish Ministry of Agriculture, Fisheries and Food and co-financed by 80% by the European Agricultural Fund for Rural Development (FEADER) (Total investment 384.830,96 EUR). It has also received funding from European Union's Horizon 2020 research and innovation program under Grant agreement no. 887281 (BIOVEXO).This study is part of the Industrial Doctorate of the doctoral student Ana Falcon Pineiro, granted by the State Research Agency of the Spanish Government, with the following reference: DIN2019-010792.Background Over the past decade, the great impact of agricultural crop diseases has generated considerable economic losses and has compromised the production of edible crops at a time when the world population is only expected to rise, leading to the search for new pest management strategies. Besides that, the environmental impact resulting from the continued use of chemical pesticides has led to the search for natural and sustainable alternatives. One of the existing solutions that currently stands out for its effectiveness is the use of bioactive plant extracts. This study aims to evaluate the antimicrobial activity of propyl propane thiosulfinate (PTS) and propyl propane thiosulfonate (PTSO), two organosulfur compounds (OSCs) derived from Allium cepa, against a wide range of target bacteria and fungi. To this end, various in vitro procedures were conducted as well as soil sanitization tests using sterile substrate inoculated with soil-borne pathogens. In addition, this study also evaluates the pesticidal activity of both compounds through in vitro mortality and repellence tests. Results PTS and PTSO revealed inhibition activity on all the pathogens tested, belonging to different taxonomic groups. Moreover, both significatively reduced the population of bacteria and fungi in soil. The quantification of active substances in soil carried out in parallel to the microbial quantification showed that their use reduces the risk of residue accumulation since they break down quickly when applied. The set of antimicrobial tests performed demonstrated that the antifungal effect of both compounds is higher than the bactericidal effect. Lastly, PTS and PTSO showed a concentration-dependent significant biocidal and repellent effect against aphids. Conclusions The results presented in this work demonstrate that both PTS and PTSO have a significant antimicrobial and pesticidal activity against the great majority of phytopathogens tested, being a promising tool to improve pest management in crops.Spanish Ministry of Agriculture, Fisheries and FoodEuropean Agricultural Fund for Rural Development (FEADER)European Union’s Horizon 2020 research and innovation program 887281State Research Agency of the Spanish Government DIN2019‑01079

Tensiones entre derecho positivo y derecho natural en las providencias judiciales ahc4806-2017 y stl12651-201

DerechoThe present monograph or Project of degree will be in charge to characterize the tensions arisen between positive right and natural right, concretely in the sentences AHC 4806-2.017 and the sentence STL 12651-2.017 each one, where the main theme circulates in the most adequate protection for a dignified life, of the sentient being "oso chucho". The method of documentary exploration was used, according to the different bibliographies found on the subject. It was taken into account for the development of the work and characterization of tensions in the aforementioned sentences, the different theories presented over time by the exponents of greater impact in the legal field, of positive law and natural law, to achieve thus to dimension to greater plenitude, the different tensions, which were found in the development of the investigations carried out.La presente monografía o Proyecto de grado se ocupará de caracterizar las tensiones surgidas entre derecho positivo y derecho natural, concretamente en las sentencias AHC 4806-2.017 y la sentencia STL 12651-2.017 cada una, donde la temática principal circula en la protección más adecuada para una vida digna, del ser sintiente “oso chucho” . Se utilizó el método de exploración documental, conforme a las distintas bibliografías encontradas del tema. Se tuvo en cuenta para el desarrollo del trabajo y caracterización de las tensiones en las sentencias anteriormente mencionadas, las distintas teorías presentadas a lo largo del tiempo por los exponentes de mayor repercusión en el ámbito legal, del derecho positivo y el derecho natural, para lograr así dimensionar a mayor plenitud, las distintas tensiones, que fueron encontradas en el desarrollo de las investigaciones realizada

Beneficial Effects of Organosulfur Compounds from Allium cepa on Gut Health: A Systematic Review

Dietary changes affect the composition and structure of gut microbiota (GM) in animals and humans. One of the beneficial effects of consuming products derived from plants is the positive influence on immunity and gastrointestinal health. Species belonging to the genus Allium contain many organosulfur compounds (OSCs) that have been widely studied showing their biological properties and beneficial effects on intestinal health and GM. This is the first systematic review of OSCs from Allium performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and it is based on the evidence that we found in literature about the benefits on the GM and intestinal health demonstrated by OSCs from Allium, and specifically from onion. OSCs from Allium cepa have shown a significant antibacterial activity against a broad spectrum of antibiotic-resistant Gram-positive and Gram-negative bacteria. In addition, the intake of OSCs from onion was able to modulate the composition of GM, increasing the beneficial bacterial populations in animal models. Moreover, the beneficial effects observed in murine models of colitis suggest that these compounds could be suitable candidates for the treatment of inflammatory bowel disease (IBD) or reverse the dysbiosis caused by a high-fat diet (HFD). Despite the evidence found both in vitro and in vivo, we have not found any article that tested OSCs different from allicin in clinical trials or dietary intervention studies in humans. In this sense, it would be interesting to conduct new research that tests the benefits of these compounds in human GM

Geotrichum candidum: properties and use as protective culture in cheeses

30 páginas, ilustraciones, anexo[ES] Geotrichum candidum es una levadura, también considerado un hongo con apariencia de levadura, ampliamente utilizado en la industria láctea. Su importancia reside principalmente en el proceso de maduración de algunos quesos, contribuyendo a la formación del sabor y aroma de estos y actuando como cultivo protector frente a algunas infecciones bacterianas y hongos contaminantes. Nuestro objetivo fue aislar cepas de G. candidum a partir de diferentes quesos de corteza enmohecida para llevar a cabo su identificación, caracterización y determinación de algunas de sus propiedades. Se emplearon galerías ID 32 C para la identificación y el análisis del perfil de azúcares, se realizó una caracterización morfológica, pruebas de proteólisis y lipólisis, un estudio de la influencia de la temperatura, actividad de agua, pH y concentración de NaCl en el crecimiento y una valoración de su efecto protector frente a hongos filamentosos. Los resultados mostraron que las cepas aisladas tenían una leve actividad proteolítica y lipolítica y la capacidad de actuar como cultivo protector frente a algunos hongos alterantes del género Penicillium. En resumen, 2 cepas se catalogaron morfológicamente dentro del morfotipo levaduriforme, las otras 3 dentro del morfotipo fungiforme. Algunas cepas de G. candidum tienen un efecto protector frente a cepas de Penicillium verrucosum y la interacción con otros microorganismos presentes en el queso incrementa las actividades proteolítica y lipolítica[EN] Geotrichum candidum is a yeast, also considered a yeast-like fungus, widely used in the dairy industry. Its importance lies mainly in the maturation process of some cheeses, contributing to the formation of their flavor and aroma and acting as a protective culture against some bacterial infections and contaminating fungi. Our objective was to isolate G. candidum strains from different moldy rind cheeses to carry out their identification, characterization, and determination of some of their properties. ID 32 C galleries were used for the identification and analysis of the sugar profile, a morphological characterization, proteolysis and lipolysis tests, a study of the influence of temperature, water activity, pH and NaCl concentration on growth and an assessment of its protective effect against filamentous fungi were performed. The results showed that the isolated strains had a slight proteolytic and lipolytic activity and the ability to act as a protective culture against some spoilage fungi of the genus Penicillium. To sum up, 2 strains were morphologically classified within the yeast morphotype and the other 3 within the fungiform morphotype. Some strains of G. candidum have a protective effect against strains of Penicillium verrucosum and the interaction with other microorganisms present in cheese increases proteolytic and lipolytic activitie

Effect of Allium Extract Supplementation on Egg Quality, Productivity, and Intestinal Microbiota of Laying Hens

Simple Summary: The growing interest in phytogenic products for use in feed, especially in the poultry sector, is mainly due to the improvement in the productivity parameters and gut microbiota modulation properties. For this reason, phytogenic products are becoming excellent candidates as alternatives to the use of antibiotics in animal production to mitigate the negative effects derived from their use. The aim of this study is to explore the ability of allium extract (containing garlic and onion), used as an ingredient in laying hen feed, to improve performance. The promising results obtained in the present study suggest that Allium spp. extracts had the potential to be used in feeding laying hens to improve productivity, without affecting egg quality, and to modulate the gut microbiota. Abstract: The use of allium extract containing propyl propane thiosulfonate (PTSO) as hen feed supplement was evaluated to demonstrate its positive effect on egg production and intestinal microbiota modulation. The study was carried out on 90 laying hens whose feed was supplemented with allium extract for 28 days. Nutritional properties of eggs were not affected, whereas an improvement in productivity was observed based on the increase weight of eggs. In addition, a modulator effect on intestinal microbiota was confirmed by the increase in Lactobacillus spp. and Bifidobacterium spp., as well as by the reduction in Enterobacteriaceae populations. Finally, the preservation of egg composition was checked by monitoring the content of PTSO, using a new analytical method consisting of the use of solid phase extraction and ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS). Consequently, based on current results, Allium spp. extract rich in organosulfur compounds such as PTSO added to the diet had a beneficial effect on the microbiota and would seem to be a possible alternative to increase productivity, while not affecting the biochemical composition of egg. However, further studies on the effects of allium extract as feed supplement are necessary.DOMCA S.A.University of Granada FQM-302University of Murcia R-1418/201

Low-power long-term ambulatory electrocardiography monitor of three leads with beat-to-beat heart rate measurement in real time

A low-power long-term ambulatory ECG monitor was developed for the acquisition, storage and processing of three simultaneous leads DI, aVF and V2 with a beat-to-beat heart rate measurement in real time. It provides long-term continuous ECG recordings until 84 h. The monitor uses a QRS complex detection algorithm based on the continuous wavelet transform with splines, which automatically selects the scale for the analysis of ECG records with different sampling frequencies. It includes a lead-off detection to continuously monitor the electrode connections and a real-time system of visual and acoustic alarms to alert users of abnormal conditions in its operation. The monitor presented is based in an ADS1294 analogue front end with four channels, 24-bit analog-to-digital converters and programmable gain amplifiers, a low-power dual-core ESP32 microcontroller, a microSD memory for data storage in a range of 4 GB to 32 GB and a 1.4 in thin-film transistor liquid crystal display (LCD) variant with a resolution of 128 × 128 pixels. It has programmable sampling rates of 250, 500 and 1000 Hz; a bandwidth of 0 Hz to 50% of the selected sampling rate; a CMRR of -105 dB; an input margin of ±2.4 V; a resolution of 286 nV; and a current consumption of 50 mA for an average battery life of 84 h. The ambulatory ECG monitor was evaluated with the commercial data-acquisition system BIOPAC MP36 and its module for ECG LABEL SS2LB, simultaneously comparing the morphologies of two ECG records and obtaining a correlation of 91.78%. For the QRS detection in real time, the implemented algorithm had an error less than 5%. The developed ambulatory ECG monitor can be used for the analysis of the dynamics of the heart rate variability in long-term ECG records and for the development of one’s own databases of ECG recordings of normal subjects and patients with cardiovascular and noncardiovascular diseases.This work has been funded by a scholarship from the CONAHCYT (México) to Frank Martínez Suárez (No. CVU = 736915), José Alberto García Limón (No. CVU = 924566), Jorge Enrique Baños-Bautista (No. CVU = 1003644) and the Spanish Agencia Estatal de Investigación under grant PID2020-116011RB-C21 (MCIN/AEI/10.13039/501100011033).Peer ReviewedPostprint (published version

Composition Classification of Ultra-High Energy Cosmic Rays

The study of cosmic rays remains as one of the most challenging research fields in Physics. From the many questions still open in this area, knowledge of the type of primary for each event remains as one of the most important issues. All of the cosmic rays observatories have been trying to solve this question for at least six decades, but have not yet succeeded. The main obstacle is the impossibility of directly detecting high energy primary events, being necessary to use Monte Carlo models and simulations to characterize generated particles cascades. This work presents the results attained using a simulated dataset that was provided by the Monte Carlo code CORSIKA, which is a simulator of high energy particles interactions with the atmosphere, resulting in a cascade of secondary particles extending for a few kilometers (in diameter) at ground level. Using this simulated data, a set of machine learning classifiers have been designed and trained, and their computational cost and effectiveness compared, when classifying the type of primary under ideal measuring conditions. Additionally, a feature selection algorithm has allowed for identifying the relevance of the considered features. The results confirm the importance of the electromagnetic-muonic component separation from signal data measured for the problem. The obtained results are quite encouraging and open new work lines for future more restrictive simulations.Spanish Ministry of Science, Innovation and Universities FPA2017-85197-P RTI2018-101674-B-I00European Union (EU)CENAPAD-SP (Centro Nacional de Processamento de Alto Desempenho em Sao Paulo) UNICAMP/FINEP - MCTFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)National Council for Scientific and Technological Development (CNPq) 2016/19764-9404993/2016-