1,086 research outputs found

    Computer vision-based analytical chemistry applied to determining iron in commercial pharmaceutical formulations

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    [EN] Two different computer vision-based analytical chemistry (CVAC) methods were developed to quantify iron in the commercial pharmaceutical formulations Ferbisol (R) and Ferro sanol (R). The methods involve using a digital camera or a desktop scanner to capture a digital image of a series of Fe2+ standard solutions and the unknown sample upon reaction with o-phenanthroline. The images are processed with appropriate software (e.g., the public domain programme ImageJ, from NIH) to obtain a numerical value (analytical signal) based on colour intensity. The fact that such a value is proportional to the analyte concentration allows one to construct a calibration graph from the standards and interpolate the value for the sample in order to determine its concentration. The results thus obtained were compared with those provided by a spectrophotometric method and the US Pharmacopoeia's recommended method. The differences never exceeded 2%. The two proposed methods are simple and inexpensive; also, they provide an effective instrumental alternative to spectrophotometric methods which can be especially beneficial in those cases where purchasing and maintaining a spectrophotometer is unaffordable.Solana-Altabella, A.; Sanchez-Iranzo, M.; Bueso-Bordils, J.; Lahuerta-Zamora, L.; Mellado Romero, AM. (2018). Computer vision-based analytical chemistry applied to determining iron in commercial pharmaceutical formulations. Talanta. 188:349-355. https://doi.org/10.1016/j.talanta.2018.06.008S34935518

    An Effective Method for InSAR Mapping of Tropical Forest Degradation in Hilly Areas

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    Current satellite remote sensing methods struggle to detect and map forest degradation, which is a critical issue as it is likely a major and growing source of carbon emissions and biodiveristy loss. TanDEM-X InSAR phase height (hϕ) is a promising variable for measuring forest disturbances, as it is closely related to the mean canopy height, and thus should decrease if canopy trees are removed. However, previous research has focused on relatively flat terrains, despite the fact that much of the world’s remaining tropical forests are found in hilly areas, and this inevitably introduces artifacts in sideways imaging systems. In this paper, we find a relationship between hϕ and aboveground biomass change in four selectively logged plots in a hilly region of central Gabon. We show that minimising multilooking prior to the calculation of hϕ strengthens this relationship, and that degradation estimates across steep slopes in the surrounding region are improved by selecting data from the most appropriate pass directions on a pixel-by-pixel basis. This shows that TanDEM-X InSAR can measure the magnitude of degradation, and that topographic effects can be mitigated if data from multiple SAR viewing geometries are available

    Does posterior capsule opacification affect the results of diagnostic technologies to evaluate the retina and the optic disc?

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    The visual outcome obtained after cataract removal may progressively decline because of posterior capsular opacification (PCO). This condition can be treated by creating an opening in the posterior lens capsule by Nd:YAG laser capsulotomy. PCO optical imperfections cause several light reflection, refraction, and diffraction phenomena, which may interfere with the functional and structural tests performed in different ocular locations for the diagnosis and follow-up of ocular disease, like macular and optic nerve diseases. Some parameters measured by visual field examinations, scanning laser polarimetry, and optical coherence tomography (OCT) have changed after PCO removal. Imaging quality also changes following capsulotomy. Consequently, the results of ancillary tests in pseudophakic eyes for studying ocular diseases like glaucoma or maculopathies should be correlated with other clinical examinations, for example, slit-lamp biomicroscopy or funduscopy. If PCO is clinically significant, a new baseline should be set for future comparisons following capsulotomy when using automated perimetry and scanning laser polarimetry. To perform OCT in the presence of PCO, reliable examinations (considering signal strength) apparently guarantee that measurements are not influenced by PCO

    Resting-state functional connectivity and socioemotional processes in male perpetrators of intimate partner violence against women

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    Intimate partner violence against women (IPVAW) is a serious and overwhelming public concern. Neuroimaging techniques have provided insights into the brain mechanisms underlying IPVAW perpetration. The purpose of this study is to examine the resting-state functional connectivity (rsFC) involving the process of social decision-making of male perpetrators. Twenty-six male perpetrators convicted for an IPVAW crime were compared to 29 men convicted for crimes other than IPVAW (other offenders) and 29 men with no criminal records (non-offenders) using a seed-based approach. Seeds were located in areas involved in reflective (prefrontal), impulsive (amygdala and striatum) and interoceptive (insula) processing. Then, as an exploratory analysis, the connectivity networks on male perpetrators were correlated with measures of executive functions and socioemotional self-report measures. Male perpetrators in comparison to other offenders and non-offenders, presented higher rsFC between prefrontal, limbic, brainstem, temporal and basal ganglia areas. Also male perpetrators showed higher rsFC between insula, default mode network and basal ganglia, while lower rsFC was found between prefrontal and motor areas and between amygdala, occipital and parietal areas. Exploratory correlations suggest that the specific rsFC in male perpetrators might be more related to socioemotional processes than to executive functions. These results showed that male perpetrators present a specific rsFC in brain systems that are essential for an adaptive social decision-making

    Designing and implementing a massive open online course: Lessons learnt

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    •In this paper, we describe the design, implementation, and evaluation of a Massive Open Online Course, or MOOC, on good practice in the application of Intellectual Property. It is aimed primarily at teachers and students, and taught in Spanish. We have used the Spanish legislation on Intellectual Property. This paper outlines the structure and content of a course developed on an ad-hoc basis, and describes its evaluation by participants in questionnaires and a final survey. The results of the initial questionnaire are framed by a) the participant''s profile, and b) by consideration of the MOOC''s implementation, given the results of the satisfaction survey. In this paper we describe the advantages of the MOOC and identify areas for improvement

    Internet gaming disorder clustering based on personality traits in adolescents, and its relation with comorbid psychological symptoms

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    Altres ajuts: This work was funded by an AIS (Atención e Investigación en Socioaddiciones) intramural research program. This research is partially supported by the Marsden grant E2987-3648 (Royal Society of New Zealand).In recent years, the evidence regarding Internet Gaming Disorder (IGD) suggests that some personality traits are important risk factors for developing this problem. The heterogeneity involved in problematic online gaming and differences found in the literature regarding the comorbid psychopathology associated with the problem could be explained through different types of gamers. Clustering analysis can allow organization of a collection of personality traits into clusters based on similarity. The objectives of this study were: (1) to obtain an empirical classification of IGD patients according to personality variables and (2) to describe the resultant groups in terms of clinical and sociodemographic variables. The sample included 66 IGD adolescent patients who were consecutive referrals at a mental health center in Barcelona, Spain. A Gaussian mixture model cluster analysis was used in order to classify the subjects based on their personality. Two clusters based on personality traits were detected: type I "higher comorbid symptoms" (n = 24), and type II "lower comorbid symptoms" (n = 42). The type I included higher scores in introversive, inhibited, doleful, unruly, forceful, oppositional, self-demeaning and borderline tendency traits, and lower scores in histrionic, egotistic and conforming traits. The type I obtained higher scores on all the Symptom Check List-90 items-Revised, all the State-Trait Anxiety Index scales, and on the DSM-5 IGD criteria. Differences in personality can be useful in determining clusters with different types of dysfunctionality

    Contract Modelling for Digital Business Ecosystems

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    The aim of this paper is to discuss the legal and technical issues of creating legally binding contracts in a digital ecosystem and to present the solution created for the DBE (Digital Business Ecosystem) project[1]. We investigate the legal implications of electronic contracts and digital signatures, and also take a brief look at the types of clauses that make up a contract. The DBE contract model for creating contracts and contract templates is presented, along with the tools created for editing these contracts as part of the DBE project
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