16 research outputs found
The effect of chemical ablation of the endocardium on ventricular fibrillation threshold.
Global genetic variation at nine short tandem repeat loci and implications on forensic genetics
Artículo científico -- Universidad de Costa Rica, Instituto de Investigaciones en Salud. 2003We have studied genetic variation at nine autosomal short tandem repeat loci in 20 globally distributed
human populations defined by geographic and ethnic origins, viz., African, Caucasian, Asian, Native
American and Oceanic. The purpose of this study is to evaluate the utility and applicability of these nine
loci in forensic analysis in worldwide populations. The levels of genetic variation measured by number of
alleles, allele size variance and heterozygosity are high in all populations irrespective of their effective
sizes. Single- as well as multi-locus genotype frequencies are in conformity with the assumptions of
Hardy-Weinberg equilibrium. Further, alleles across the entire set of nine loci are mutually independent
in all populations. Gene diversity analysis shows that pooling of population data by major geographic
groupings does not introduce substructure effects beyond the levels recommended by the National
Research Council, validating the establishment of population databases based on major geographic and
ethnic groupings. A network tree based on genetic distances further supports this assertion, in which
populations of common ancestry cluster together. With respect to the power of discrimination and
exclusion probabilities, even the relatively reduced levels of genetic variation at these nine STR loci in
smaller and isolated populations provide an exclusionary power over 99%. However, in paternity testing
with unknown genotype of the mother, the power of exclusion could fall below 80% in some isolated
populations, and in such cases use of additional loci supplementing the battery of the nine loci is
recommended.Universidad de Costa Rica. Instituto de Investigaciones en SaludUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones en Salud (INISA
The Autonomic Control of the Transmural Dispersion of Ventricular Repolarization in Anesthetized Dogs
Effects of Autonomic Manipulation on Ventricular Fibrillation and Internal Cardiac Defibrillation Thresholds in Pigs
Nuclear Genetic Diversity in Human Lice (Pediculus humanus) Reveals Continental Differences and High Inbreeding among Worldwide Populations
Device-Based Autonomic Modulation in Arrhythmia Patients: the Role of Vagal Nerve Stimulation
Vagal nerve stimulation (VNS) has shown promise as an adjunctive therapy for management of cardiac arrhythmias by targeting the cardiac parasympathetic nervous system. VNS has been evaluated in the setting of ischemia-driven ventricular arrhythmias and atrial arrhythmias, as well as a treatment option for heart failure. As better understanding of the complexities of the cardiac autonomic nervous system is obtained, vagal nerve stimulation will likely become a powerful tool in the current cardiovascular therapeutic armamentarium