Hierarchical Spatial Organization of Geographical Networks

In this work we propose the use of a hirarchical extension of the polygonality index as a means to characterize and model geographical networks: each node is associated with the spatial position of the nodes, while the edges of the network are defined by progressive connectivity adjacencies. Through the analysis of such networks, while relating its topological and geometrical properties, it is possible to obtain important indications about the development dynamics of the networks under analysis. The potential of the methodology is illustrated with respect to synthetic geographical networks.Comment: 3 page, 3 figures. A wokring manuscript: suggestions welcome

Three Dimensional de Sitter Gravity and the Correspondence

Certain aspects of three dimensional asymptotically de Sitter spaces are studied, with emphasis on the mapping between gravity observables and the representation of the conformal symmetry of the boundary. In particular, we show that non-real conformal weights for the boundary theory correspond to space-times that have non-zero angular momentum. Some miscellaneous results on the role of the holonomies and isometry groups are also presented.Comment: 10 pages, 1 figure, uses epsf. Added references and a discussion on the (dis)similarities with previous work

DyNetVis: a system for visualization of dynamic networks

The concept of networks has been important in the study of complex systems. In networks, links connect pairs of nodes forming complex structures. Studies have shown that networks not only contain structure but may also evolve in time. The addition of the temporal dimension adds complexity on the analysis and requests the development of innovative methods for the visualization of real-life networks. In this paper we introduce the Dynamic Network Visualization System (DyNetVis), a software tool for visualization of dynamic networks. The system provides several tools for user interaction and offers two coordinated visual layouts, named structural and temporal. Structural refers to standard network drawing techniques, in which a single snapshot of nodes and links are placed in a plane, whereas the temporal layout allows for simultaneously visualization of several temporal snapshots of the dynamic network. In addition, we also investigate two approaches for temporal layout visualization: (i) Recurrent Neighbors, a node ordering strategy that highlights frequent connections in time, and (ii) Temporal Activity Map (TAM), a layout technique with focus on nodes activity. We illustrate the applicability of the layouts and interaction functionalities provided by the system in two visual analysis case studies, demonstrating their advantages to improve the overall user experience on visualization and exploratory data analysis on dynamic networks

Downhill Running-based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway Without Concomitant Decrease Of Inflammatory Proteins

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)The purpose of this study was to verify the effects of overtraining (OT) on insulin, inflammatory and gluconeogenesis signaling pathways in the livers of mice. Rodents were divided into control (CT), overtrained by downhill running (OTR/down), overtrained by uphill running (OTR/up) and overtrained by running without inclination (OTR). Rotarod, incremental load, exhaustive and grip force tests were used to evaluate performance. Thirty-six hours after a grip force test, the livers were extracted for subsequent protein analyses. The phosphorylation of insulin receptor beta (pIRbeta), glycogen synthase kinase 3 beta (pGSK3beta) and forkhead box O1 (pFoxo1) increased in OTR/down versus CT. pGSK3beta was higher in OTR/up versus CT, and pFoxo1 was higher in OTR/up and OTR versus CT. Phosphorylation of protein kinase B (pAkt) and insulin receptor substrate 1 (pIRS-1) were higher in OTR/up versus CT and OTR/down. The phosphorylation of I kappa B kinase alpha and beta (pIK-Kalpha/beta) was higher in all OT protocols versus CT, and the phosphorylation of stress-activated protein kinases/Jun amino-terminal kinases (pSAPK-JNK) was higher in OTR/ down versus CT. Protein levels of peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) and hepatocyte nuclear factor 4alpha (HNF-4alpha) were higher in OTR versus CT. In summary, OTR/down improved the major proteins of insulin signaling pathway but up-regulated TRB3, an Akt inhibitor, and its association with Akt.1010Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP [2013/20591-3, 2014/25459-9, 2013/22737-5, 2013/19985-7

Inflation and Holography in String Theory

The encoding of an inflating patch of space-time in terms of a dual theory is discussed. Following Bousso's interpretation of the holographic principle, we find that those are generically described not by states in the dual theory but by density matrices. We try to implement this idea on simple deformations of the AdS/CFT examples, and an argument is given as to why inflation is so elusive to string theory.Comment: 15 pages, LaTeX, 2 figures. Uses psbox.te

Perception of sleep duration in adult patients with suspected obstructive sleep apnea

PURPOSE: Discrepancies between subjective and objective measures of total sleep time (TST) are frequent among insomnia patients, but this issue remains scarcely investigated in obstructive sleep apnea (OSA). We aimed to evaluate if sleep perception is affected by the severity of OSA. METHODS: We performed a 3-month cross-sectional study of Brazilian adults undergoing overnight polysomnography (PSG). TST was objectively assessed from PSG and by a self-reported questionnaire (subjective measurement). Sleep perception index (SPI) was defined by the ratio of subjective and objective values. Diagnosis of OSA was based on an apnea/hypopnea index (AHI) ≥ 5.0/h, being its severity classified according to AHI thresholds: 5.0-14.9/h (mild OSA), 15.0-29.9/h (moderate OSA), and ≥ 30.0/h (severe OSA). RESULTS: Overall, 727 patients were included (58.0% males). A significant difference was found in SPI between non-OSA and OSA groups (p = 0.014). Mean SPI values significantly decreased as the OSA severity increased: without OSA (100.1 ± 40.9%), mild OSA (95.1 ± 24.6%), moderate OSA (93.5 ± 25.2%), and severe OSA (90.6 ± 28.2%), p = 0.036. Using logistic regression, increasing SPI was associated with a reduction in the likelihood of presenting any OSA (p = 0.018), moderate/severe OSA (p = 0.019), and severe OSA (p = 0.028). However, insomnia was not considered as an independent variable for the presence of any OSA, moderate/severe OSA, and severe OSA (all p-values > 0.05). CONCLUSION: In a clinical referral cohort, SPI significantly decreases with increasing OSA severity, but is not modified by the presence of insomnia symptoms.publishersversionpublishe

Tachyon Effective Dynamics and de Sitter Vacua

We show that the DBI action for the singlet sector of the tachyon in two-dimensional string theory has a SL(2,R) symmetry, a real-time counterpart of the ground ring. The action can be rewritten as that of point particles moving in a de Sitter space, whose coordinates are given by the value of the eigenvalue and time. The symmetry then manifests as the isometry group of de Sitter space in two dimensions. We use this fact to write the collective field theory for a large number of branes, which has a natural interpretation as a fermion field in this de Sitter space. After spending some time building geometrical insight on facts about the condensation process, the state corresponding to a sD-brane is identified and standard results in quantum field theory in curved space-time are used to compute the backreaction of the thermal background.Comment: 28 pages, 1 eps figure. Uses graphicx, setspace. v2:corrected typos, added references, clarified discussion on backreactio

The use of happiness research for public policy

Research on happiness tends to follow a "benevolent dictator" approach where politicians pursue people's happiness. This paper takes an antithetic approach based on the insights of public choice theory. First, we inquire how the results of happiness research may be used to improve the choice of institutions. Second, we show that the policy approach matters for the choice of research questions and the kind of knowledge happiness research aims to provide. Third, we emphasize that there is no shortcut to an optimal policy maximizing some happiness indicator or social welfare function since governments have an incentive to manipulate this indicator

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast

Acknowledgments We thank Rebecca Shapiro for creating CaLC1819, CaLC1855 and CaLC1875, Gillian Milne for help with EM, Aaron Mitchell for generously providing the transposon insertion mutant library, Jesus Pla for generously providing the hog1 hst7 mutant, and Cathy Collins for technical assistance.Peer reviewedPublisher PD