Guest editorial: Creating, managing and marketing gastronomy experiences in hospitality and tourism

Gastronomy experiences are increasingly becoming major drivers of tourism flows worldwide as they allow travelers to get more familiar with the local culture and traditions of the places visited. As such, gastronomy experiences have propelled gastronomic hospitality and tourism experiences which are attracting the attention of a high and expanding number of hospitality and tourism firms and fostering regional tourism development. Gastronomic tourism experiences entail the visit to food-themed events and festivals, primary and secondary producers, cooking classes, restaurants and places for which food tasting are the prevailing travel motivating factors. Research on this socio-cultural and economic phenomenon has been consolidating over more than three decades as an area of tourism research, often named interchangeably “gastronomic tourism”, “culinary tourism” and “food tourism”. The purpose of this special issue is to broaden and deepen our knowledge of gastronomy experiences in hospitality and tourism, from a managerial perspective, in a rapidly changing world

The competitive productivity (CP) of tourism destinations: an integrative conceptual framework and a reflection on big data and analytics

Purpose: The purpose of this study is twofold. First, this study elaborates an integrative conceptual framework of tourism destination competitive productivity (TDCP) by blending established destination competitiveness frameworks, the competitive productivity (CP) framework and studies pertaining to big data and big data analytics (BDA) within destination management information systems and smart tourism destinations. Second, this study examines the drivers of TDCP in the context of the ongoing 4th industrial revolution by conceptualizing the destination business intelligence unit (DBIU) as a platform able to create sustained destination business intelligence under the guise of BDA, useful to support destination managers to achieve the tourism destination’s economic objectives. Design/methodology/approach: In this work, the authors leverage both extant literature (under the guise of research on CP, tourism destination competitiveness [TDC] and destination management information systems) and empirical work (in the form of interviews and field work involving destination managers and chief executive officers of destination management organizations and convention bureaus, as well as secondary data) to elaborate, develop and present an integrative conceptual framework of TDCP. Findings: The integrative conceptual framework of TDCP elaborated has been found helpful by a number of destination managers trying to understand how to effectively and efficiently manage and market a tourism destination in today’s fast-paced, digital and hypercompetitive environment. While DBIUs are at different stages of implementation, often as part of broader smart destination initiatives, it appears that they are increasingly fulfilling the purpose of creating sustained destination business intelligence by means of BDA to help tourism destinations achieve their economic goals. Research limitations/implications: This work bears several practical implications for tourism policymakers, destination managers and marketers, technology developers, as well as tourism and hospitality firms and practitioners. Tourism policymakers could embed TDCP into tourism and economic policies, and destination managers and marketers might build and make use of platforms such as the proposed DBIU. Technology developers need to understand that designing destination management information systems in general and more specifically DBIUs requires an in-depth analysis of the stakeholders that are going to contribute, share, control and use BDA. Originality/value: To the best of the authors’ knowledge, this study constitutes the first attempt to integrate the CP, TDC and destination management information systems research streams to elaborate an integrative conceptual framework of TDCP. Second, the authors contribute to the Industry 4.0 research stream by examining the drivers of tourism destination CP in the context of the ongoing 4th industrial revolution. Third, the authors contribute to the destination management information systems research stream by introducing and conceptualizing the DBIU and the related sustained destination business intelligence

Erratum to: Design of pharmaceutical products to meet future patient needs requires modification of current development paradigms and business models

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The management of organizational ambidexterity through alliances in a new context of analysis: Internet of Things (IoT) smart city projects

In the last decade, the Internet of Things (IoT) has affected the approach of organizations to innovation and how they create and capture value in everyday business activities. This is compounded in the so-called Smart Cities, where the objective of the IoT is to exploit information and communication technologies (ICTs) to support added-value services for citizens, giving companies more opportunities to innovate through the use of the latest technologies. In this context, multinational enterprises (MNEs) are building alliances, starting several projects with public and private city stakeholders aimed at exploring new technologies for cities but also at exploiting new IoT-based devices and services in order to profit from them. This implies that companies need to manage and integrate different types of knowledge to efficiently and effectively support the simultaneous pressure of exploration and exploitation, at a project portfolio level. Using structural equations modeling with data collected from 43 IoT smart city project alliances in Italy, this paper tests and finds evidence that MNEs need to develop knowledge management (KM) capabilities combined with ICT capabilities if they want to obtain greater ambidexterity performance at the project portfolio level. More specifically, we highlight that KM capabilities enhance alliance ambidexterity indirectly through firms’ ICT capabilities, suggesting that MNE managers should design KM tools and develop new ICT skills. Implications for academics, managers and future lines of research are proposed. © 2017 Elsevier Inc.Health and Safety Executive, HSE; National Research University Higher School of Economics, ВШЭ; Government Council on Grants, Russian FederationThe article was prepared within the framework of the Basic Research Program at the National Research University Higher School of Economics (HSE) and supported within the framework of the subsidy granted to the HSE by the Government of the Russian Federation for the implementation of the Global Competitiveness Program

Prevalência de anticorpos anti-Toxoplasma gondii em caprinos.

Resumo: A Toxoplasmose pode ser congênita ou adquirida e representa uma das infecções parasitárias mais comuns em caprinos, de qualquer faixa etária, raça e/ou sexo. Estudos epidemiológicos realizados no Brasil e no mundo apontam que a prevalência de anticorpos anti-Toxoplasma gondii varia entre 10% a 86%, independente do sistema de produção adotado. Objetivou-se com este estudo avaliar a prevalência de anticorpos anti-Toxoplasma gondii em caprinos de oito propriedades rurais de Quixadá, Ceará. Foram realizadas coletas de sangue por venipunção da jugular de 93 cabritos, machos e fêmeas, com mais de quatro meses de idade; 54 matrizes e três reprodutores. Os sangues foram centrifugados a 3000xg por 10 minutos para obtenção do soro. Estes foram armazenados em tubos tipo eppendorf® e congelados a -20°C até o momento da realização do teste ELISA indireto, usando como antígeno taquizoítos de T. gondii. A pesquisa foi aprovada pela Comissão de Ética no Uso de Animais da FCAV-UNESP, sob o protocolo 014465/12. As análises estatísticas foram realizadas no programa EPI Info 7.0.9.7 utilizando-se o teste Qui-quadrado. A prevalência de anticorpos anti-T. gondii encontrada: nas oito propriedades foi de 23,33% (35/150) e para as diferentes categorias animais de 15,05% (14/93) para crias; 37,04% (20/54) para matrizes e 33,33% (1/3) para os reprodutores, quando essas foram comparadas houve diferença estatística entre crias x matrizes (P = 0,0006) e crias x reprodutores (P = 0,004). Com relação ao sexo a prevalência encontrada para fêmeas foi de 25,21% (30/119) e para machos de 16,13% (5/31), não foi observada diferença estatística (P = 0,16). O sistema de produção adotado na maioria das propriedades era misto, ou seja, produzia-se carne e leite. Em todas as propriedades estudadas foi encontrado pelo menos um animal soropositivo para T. gondii, demonstrando que formas infectantes do protozoário estão presentes na região estudada. [Prevalence of Toxoplasma gondii antibodies in goats]. Congenital or acquired toxoplasmosis is one of the most common parasitic infections in goats of any age, race and sex. Epidemiological studies carried out in Brazil and around the world show that the prevalence of Toxoplasma gondii antibodies ranges from 10% to 86%, regardless of the adopted production system. The objective of this study was to evaluate the prevalence of antibodies to Toxoplasma gondii in goats from eight farms in Quixadá, Ceará. Blood samples were collected by jugular venipuncture of 93 male and female little goats, older than four months; 54 does and three bucks (breeders). The blood samples were centrifuged at 3000xg for 10 minutes to separate the serum. Serum samples were stored in Eppendorf ® tubes and frozen at -20°C for further testing by the indirect ELISA using as antigen tachyzoites of T. gondii. The study was approved by the Ethics Committee on Animal Use of FCAV - UNESP, under protocol 014465/12. Statistical analyses were performed by the Epi Info 7.0.9.7 software using the Chi-square test. The prevalence of T. gondii antibody for the eight properties studied was as follows: 23.33% (35/150) while within the animal categories, they were 15.05% (14/93) for offspring; 37.04% (20/54) for does; 33% (1/3) for bucks. The statistical analysis showed significant differences between offspring x does (P=0.0006) and offspring x bucks (P=0.004). With respect to gender, the prevalence for does was 25.21% (30/119) while for bucks, it was 16.13% (5/31), but they were not statistically different (P=0.16). The production system adopted in the majority of properties was mixed, that is, they produced meat and milk. All the properties had at least one animal positive for T. gondii, demonstrating that infectious forms of the parasite are present in the studied region.Edição dos Resumos do I Simpósio Internacional de Medicina Veterinária Preventiva (SIMPREV), Jaboticabal, 2013

Interaction of perceptual grouping and crossmodal temporal capture in tactile apparent-motion

Previous studies have shown that in tasks requiring participants to report the direction of apparent motion, task-irrelevant mono-beeps can "capture'' visual motion perception when the beeps occur temporally close to the visual stimuli. However, the contributions of the relative timing of multimodal events and the event structure, modulating uni- and/or crossmodal perceptual grouping, remain unclear. To examine this question and extend the investigation to the tactile modality, the current experiments presented tactile two-tap apparent-motion streams, with an SOA of 400 ms between successive, left-/right-hand middle-finger taps, accompanied by task-irrelevant, non-spatial auditory stimuli. The streams were shown for 90 seconds, and participants' task was to continuously report the perceived (left-or rightward) direction of tactile motion. In Experiment 1, each tactile stimulus was paired with an auditory beep, though odd-numbered taps were paired with an asynchronous beep, with audiotactile SOAs ranging from -75 ms to 75 ms. Perceived direction of tactile motion varied systematically with audiotactile SOA, indicative of a temporal-capture effect. In Experiment 2, two audiotactile SOAs-one short (75 ms), one long (325 ms)-were compared. The long-SOA condition preserved the crossmodal event structure (so the temporal-capture dynamics should have been similar to that in Experiment 1), but both beeps now occurred temporally close to the taps on one side (even-numbered taps). The two SOAs were found to produce opposite modulations of apparent motion, indicative of an influence of crossmodal grouping. In Experiment 3, only odd-numbered, but not even-numbered, taps were paired with auditory beeps. This abolished the temporal-capture effect and, instead, a dominant percept of apparent motion from the audiotactile side to the tactile-only side was observed independently of the SOA variation. These findings suggest that asymmetric crossmodal grouping leads to an attentional modulation of apparent motion, which inhibits crossmodal temporal-capture effects

Subsidiary innovation performance: Balancing external knowledge sources and internal embeddedness

The open innovation (OI) literature has focused primarily on OI strategies and external sourcing of knowledge at the organizational level and has paid less attention to the role of subsidiaries in the OI activities of multinational corporations (MNCs). In contrast, International Business (IB) scholars have shown that subsidiaries play an emergent role in MNC innovation activities and have highlighted the relevance of subsidiaries' external and internal linkages. In this paper, we bring together these perspectives by examining OI at the subsidiary level within MNCs and test our hypotheses through an empirical analysis using data from 91 MNC subsidiaries. Our findings show an inverted U-shaped relationship between the openness of subsidiaries to external knowledge sources and innovation performance. Moreover, we find that subsidiaries' internal embeddedness positively moderates the above relationship. Practically, our findings suggest the need for MNC and subsidiary managers to develop mechanisms to manage intra-organizational relations in order to achieve improved innovation performance while leveraging of external knowledge sources at the subsidiary level, thus favoring MNCs' knowledge management (KM) approach. We contribute to different interrelated streams of research by providing compelling evidence to support the assertion that subsidiaries need to balance external and internal openness. © 2020 Elsevier Inc.Novo Nordisk Fonden, NNF: NNF16OC0021630Marcel Bogers would like to acknowledge the support of the Novo Nordisk Foundation (grant number NNF16OC0021630 )

Introduction: Ugly Emotions and the Politics of Accusation

This the author accepted manuscript. The final version is available from Berghahn via the DOI in this recordUgly emotions like envy and greed tend to emerge ethnographically through accusations (as opposed to self-attribution), de-centring the individual psyche and drawing attention to how emotions are deployed in broader projects of moral policing. Tracking the moral, social dimension of emotions through accusations helps to account concretely for the political, economic and ideological factors that shape people’s ethical worldviews – their defences, judgements and anxieties. Developing an anthropological understanding of these politics of accusation leads us to connect classical anthropological themes of witchcraft, scapegoating, and interand intra-communal conflict with ethnographic interventions into contemporary debates around speculative bubbles, inequality, migration, climate change and gender. We argue that a focus on the politics of accusation that surrounds envy and greed has the potential to allow for a more analytically subtle and grounded understanding of both ethics and emotions

The D647N mutation of FGFR1 induces ligand-independent receptor activation

The activation loop (A-loop) of kinases, a key regulatory region, is recurrently mutated in several kinase proteins in cancer resulting in dysregulated kinase activity and response to kinase inhibitors. FGFR1 receptor tyrosine kinase represents an important oncogene and therapeutic target for solid and hematological tumors. Here we investigate the biochemical and molecular effects of D647N mutation lying in the A-loop of FGFR1.When expressed in normal and tumoral in vitro cell models, FGFR1D647N is phosphorylated also in the absence of ligands, and this is accompanied by the activation of intracellular signaling. The expression of FGFR1D647N significantly increases single and collective migration of cancer cells in vitro and in vivo, when compared to FGFR1WT. FGFR1D647N expression exacerbates the aggressiveness of cancer cells, increasing their invasiveness in vitro and augmenting their pro-angiogenic capacity in vivo.Remarkably, the D647N mutation significantly increases the sensitivity of FGFR1 to the ATP-competitive inhibitor Erdafitinib suggesting the possibility that this mutation could become a specific target for the development of new inhibitors. Although further efforts are warranted for an exhaustive description of the activation mechanisms, for the identification of more specific inhibitors and for confirming the clinical significance of mutated FGFR1D647N, overall our data demonstrate that the D647N substitution of FGFR1 is a novel pro-oncogenic activating mutation of the receptor that, when found in cancer patients, may anticipate good response to erdafitinib treatment