How neutral is the intergalactic medium surrounding the redshift z=7.085 quasar ULAS J1120+0641?

The quasar ULAS J1120+0641 at redshift z=7.085 has a highly ionised near zone which is smaller than those around quasars of similar luminosity at z~6. The spectrum also exhibits evidence for a damping wing extending redward of the systemic Lya redshift. We use radiative transfer simulations in a cosmological context to investigate the implications for the ionisation state of the inhomogeneous IGM surrounding this quasar. Our simulations show that the transmission profile is consistent with an IGM in the vicinity of the quasar with a volume averaged HI fraction of f_HI>0.1 and that ULAS J1120+0641 has been bright for 10^6--10^7 yr. The observed spectrum is also consistent with smaller IGM neutral fractions, f_HI ~ 10^-3--10-4, if a damped Lya system in an otherwise highly ionised IGM lies within 5 proper Mpc of the quasar. This is, however, predicted to occur in only ~5 per cent of our simulated sight-lines for a bright phase of 10^6--10^7 yr. Unless ULAS J1120+0641 grows during a previous optically obscured phase, the low age inferred for the quasar adds to the theoretical challenge of forming a 2x10^9 M_sol black hole at this high redshift.Comment: 5 pages, 4 figures, accepted to MNRAS letter

A Search for Nitrogen Enriched Quasars in the Sloan Digital Sky Survey Early Data Release

A search for nitrogen-rich quasars in the Sloan Digital Sky Survey Early Data Release (SDSS EDR) catalog has yielded 16 candidates, including five with very prominent emission, but no cases with nitrogen emission as strong as in Q0353-383. The quasar Q0353-383 has long been known to have extremely strong nitrogen intercombination lines at lambda 1486 and lambda 1750 Angstroms, implying an anomalously high nitrogen abundance of about 15 times solar. It is still the only one of its kind known. A preliminary search through the EDR using the observed property of the weak C IV emission seen in Q0353-383 resulted in a sample of 23 objects with unusual emission or absorption-line properties, including one very luminous redshift 2.5 star-forming galaxy. We present descriptions, preliminary emission-line measurements, and spectra for all the objects discussed here.Comment: 20 pages, 5 figures, submitted to AJ; final refereed versio

Metal abundances at z<1.5: new measurements in sub-Damped Lyman-alpha Absorbers

Damped Lyman-alpha systems (DLAs) and sub-DLAs seen toward background quasars provide the most detailed probes of elemental abundances. Somewhat paradoxically these measurements are more difficult at lower redshifts due to the atmospheric cut-off, and so a few years ago our group began a programme to study abundances at z < 1.5 in quasar absorbers. In this paper, we present new UVES observations of six additional quasar absorption line systems at z < 1.5, five of which are sub-DLAs. We find solar or above solar metallicity, as measured by the abundance of zinc, assumed not to be affected by dust, in two sub-DLAs: one, towards Q0138-0005 with [Zn/H]=+0.28 +/- 0.16; the other towards Q2335+1501 with [Zn/H]=+0.07 +/- 0.34. Relatively high metallicity was observed in another system: Q0123-0058 with [Zn/H]=-0.45 +/- 0.20. Only for the one DLA in our sample, in Q0449-1645, do we find a low metallicity, [Zn/H]=-0.96 +/- 0.08. We also note that in some of these systems large relative abundance variations from component to component are observed in Si, Mn, Cr and Zn.Comment: 7 figures and 10 tables. Accepted for publication in MNRA

Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis.

This study investigated the antispasticity potential of Sativex in mice. Chronic relapsing experimental allergic encephalomyelitis was induced in adult ABH mice resulting in hind limb spasticity development. Vehicle, Sativex, and baclofen (as a positive control) were injected intravenously and the "stiffness" of limbs assessed by the resistance force against hind limb flexion. Vehicle alone caused no significant change in spasticity. Baclofen (5 mg/kg) induced approximately a 40% peak reduction in spasticity. Sativex dose dependently reduced spasticity; 5 mg/kg THC + 5 mg/kg CBD induced approximately a 20% peak reduction; 10 mg/kg THC + 10 mg/kg CBD produced approximately a 40% peak reduction in spasticity. Sativex has the potential to reduce spasticity in an experimental mouse model of multiple sclerosis (MS). Baclofen reduced spasticity and served as a positive control. Sativex (10 mg/kg) was just as effective as baclofen, providing supportive evidence for Sativex use in the treatment of spasticity in MS

Possible evidence for an inverted temperature-density relation in the intergalactic medium from the flux distribution of the Lyman-alpha forest

We compare the improved measurement of the Lya forest flux probability distribution at 1.7<z<3.2 presented by Kim et al. (2007) to a large set of hydrodynamical simulations of the Lya forest with different cosmological parameters and thermal histories. The simulations are in good agreement with the observational data if the temperature-density relation for the low density intergalactic medium (IGM), T=T_0 Delta^{gamma-1}, is either close to isothermal or inverted (gamma<1). Our results suggest that the voids in the IGM may be significantly hotter and the thermal state of the low density IGM may be substantially more complex than is usually assumed at these redshifts. We discuss radiative transfer effects which alter the spectral shape of ionising radiation during the epoch of HeII reionisation as a possible physical mechanism for achieving an inverted temperature-density relation at z~3.Comment: 16 pages, 6 figures, accepted for publication in MNRAS following minor revision. The accepted version includes an expanded discussion of the flux power spectru

Dietary intake in post-menopausal women

Si has been suggested as an essential element, and may be important in optimal bone, skin and cardiovascular health. However, there are few estimates of dietary Si intakes in man, especially in a UK population. Following the development of a UK food composition database for Si, the aim of the present study was to investigate dietary intakes of Si amongst healthy women aged over 60 years and to identify important food sources of Si in their diet. Healthy, post-menopausal female subjects (&gt;60 years of age; n 209) were recruited from the general population around Dundee, Scotland as part of an unrelated randomised controlled intervention study where dietary intake was assessed using a self-administered, semi-quantitative food-frequency questionnaire at five time-points over a 2-year period. Food composition data on the Si content of UK foods was used to determine the Si content of food items on the food-frequency questionnaire. Mean Si intake was 18&middot;6 (sd 4&middot;6) mg and did not vary significantly across the 2 years of investigation. Cereals provided the greatest amount of Si in the diet (about 30%), followed by fruit, beverages (hot, cold and alcoholic beverages combined) and vegetables; together these foods provided over 75% about Si intake. Si intakes in the UK appear consistent with those reported previously for elderly women in Western populations, but lower than those reported for younger women or for men.<br /

Closing in on the picture : analyzing interactions in video recordings

This paper provides a detailed account of the processing and analysing of data, obtained through video recording during reflective practitioner research. It sets out five stages in the analysis of video recordings of classroom interactions during a series of educational drama lessons: from decisions relating to the selection of data for close analysis, to the seeking of themes, and finally to the presentation of conclusions. The researcher adapted and synthesised several processes derived from discourse analysis (Wells, 2001; Spiers, 2004; Gee, 2005) to produce a range of instruments for use in transcription and analysis of verbal and non-verbal discourse. These include: a simple transcription key; classifications for verbal and non-verbal discourse; and a template for a transcription and analysis matrix

Crossover from Fermi liquid to Wigner molecule behavior in quantum dots

The crossover from weak to strong correlations in parabolic quantum dots at zero magnetic field is studied by numerically exact path-integral Monte Carlo simulations for up to eight electrons. By the use of a multilevel blocking algorithm, the simulations are carried out free of the fermion sign problem. We obtain a universal crossover only governed by the density parameter $r_s$. For $r_s>r_c$, the data are consistent with a Wigner molecule description, while for $r_s<r_c$, Fermi liquid behavior is recovered. The crossover value $r_c \approx 4$ is surprisingly small.Comment: 4 pages RevTeX, 3 figures, corrected Tabl