Chapter Il ricettario gesuato lucchese del 1562: prime osservazioni linguistiche

The contribution examines the Libro de i secretti et ricette, composed in 1562 by Frate Giovanni Andrea de Farre, which constitutes an interesting testimony of specialistic language related to pharmacology between the Middle Ages and the Modern Age. It focuses mainly on a quantitative analysis of the lexicon and on the potentialities for research through the creation of a glossary. It also dwells on some linguistic features functional to the identification of possible diachronic and diatopic stratificated layers of the text, probably related to written and oral recipes of various origins

Herramienta de intervención para una niña con autismo en el contexto escolar: Emergencia de oraciones sintácticamente correctas y productivas por medio de procedimientos de transferencia de control de estímulos

En el presente artículo se describe el producto de un programa corto de intervención realizado con una niña diagnosticada con autismo, quien durante el desarrollo del proyecto cursaba quinto grado en una institución educativa distrital de la ciudad de Bogotá. Se realizó una evaluación inicial de habilidades y dificultades, y un plan corto de intervención que consistió en el diseño de un librillo a partir de las producciones verbales y los dibujos que la niña hizo con material didáctico como guía (imágenes de personajes realizando acciones). La clase de conducta que se procuró enseñarle, fue la descripción oral de acciones con una oración sintácticamente correcta y productiva a partir de ilustraciones. Se discuten los resultados a la luz de los procedimientos utilizados desde el análisis conductual para facilitar la emergencia de conductas no entrenadas directamente y la transferencia del control de la respuesta correcta por medio del desvanecimiento de ayudas

Herramienta de intervención para una niña con autismo en el contexto escolar: Emergencia de oraciones sintácticamente correctas y productivas por medio de procedimientos de transferencia de control de estímulos

En el presente artículo se describe el producto de un programa corto de intervención realizado con una niña diagnosticada con autismo, quien durante el desarrollo del proyecto cursaba quinto grado en una institución educativa distrital de la ciudad de Bogotá. Se realizó una evaluación inicial de habilidades y dificultades, y un plan corto de intervención que consistió en el diseño de un librillo a partir de las producciones verbales y los dibujos que la niña hizo con material didáctico como guía (imágenes de personajes realizando acciones). La clase de conducta que se procuró enseñarle, fue la descripción oral de acciones con una oración sintácticamente correcta y productiva a partir de ilustraciones. Se discuten los resultados a la luz de los procedimientos utilizados desde el análisis conductual para facilitar la emergencia de conductas no entrenadas directamente y la transferencia del control de la respuesta correcta por medio del desvanecimiento de ayudas

Arts-Based Research in the Social and Health Sciences: Pushing for Change with an Interdisciplinary Global Arts-Based Research Initiative

The impact of current trends in technology, digitalization and mass media on our global culture raises questions regarding the responsibility and ethics of research decisions in contemporary social and health sciences. Embedded in the dominant paradigms, these trends subtly affect our worldviews, our valuation of the human condition, and the nature of socio-political discourse. In such critical post normal times (SARDAR, 2009) radical imagination (HAIVEN & KHASNABISH, 2014) and epistemic activism, embracing non-dominant modes of knowledge production in the social and health sciences, becomes a necessity. Arts-based research (ABR) is resonant with the onto-epistemological perspectives and methodologies necessary to challenge and disrupt current unilateral and hegemonic paradigms underlying decaying societal and geo-political constructs. In this article, we advocate for the development of a global network of ABR scholars and stakeholders invoking a radical imaginative philosophy and arts-based research methodologies as an approach to social activism and epistemological change.Die Wichtigkeit aktueller Trends in Technologie, Digitalisierung und Massenmedien für die globale Kultur führt zu Fragen nach der Verantwortlichkeit und Ethik forscherischer Entscheidungen in den Sozial- und Gesundheitswissenschaften. Eingebettet in die jeweils dominanten Paradigmen affizieren diese Trends subtil unsere Weltsicht, unsere Werte und den Charakter sozio-politischer Diskurse. In diesen kritischen post-normalen Zeiten (SARDAR 2009) werden radikale Imagination (HAIVEN & KHASNABISH 2014) und epistemischer Aktivismus, verbunden mit nicht-dominanten Weisen der Wissensproduktion, zu einer Notwendigkeit. Kunstbasierte Forschung (KBF) beinhaltet onto-epistemologische Perspektiven und Methodologien, die erforderlich sind, um die gegenwärtigen unilateralen und hegemonialen Paradigmen herauszufordern und zu stören, die den überkommenen gesellschaftlichen und geo-politischen Konstrukten unterliegen. In diesem Beitrag vertreten wir die Etablierung eines globalen Netzwerks von KBF-Wissenschaftler*innen und Stakeholdern und die Nutzung einer radikal-imaginativen Philosophie und von kunstbasierten Verfahren als Ausgangspunkte für sozialen Aktivismus und einen epistemologischen Wechsel

Dual binding of an antibody and a small molecule increases the stability of TERRA G-quadruplex.

In investigating the binding interactions between the human telomeric RNA (TERRA) G-quadruplex (GQ) and its ligands, it was found that the small molecule carboxypyridostatin (cPDS) and the GQ-selective antibody BG4 simultaneously bind the TERRA GQ. We previously showed that the overall binding affinity of BG4 for RNA GQs is not significantly affected in the presence of cPDS. However, single-molecule mechanical unfolding experiments revealed a population (48%) with substantially increased mechanical and thermodynamic stability. Force-jump kinetic investigations suggested competitive binding of cPDS and BG4 to the TERRA GQ. Following this, the two bound ligands slowly rearrange, thereby leading to the minor population with increased stability. Given the relevance of G-quadruplexes in the regulation of biological processes, we anticipate that the unprecedented conformational rearrangement observed in the TERRA-GQ-ligand complex may inspire new strategies for the selective stabilization of G-quadruplexes in cells.H.M. acknowledges support from NSF CHE-1026532. The Balasubramanian lab is supported by programme funding from Cancer Research UK.This is the final published version. It first appeared at http://onlinelibrary.wiley.com/doi/10.1002/anie.201408113/abstract;jsessionid=BB18FC03F2AF0C3EB95EC57CCBDB3DB9.f01t01

The FutureMine collaborative research initiative : making research work

The FutureMine Collaborative Research Initiative has been successfully completed after three years of activity. The main objective of this initiative was to provide applications of research previously undertaken in the DeepMine initiative in terms of realistic solutions to problems facing gold mining operations as they reach for depths beyond 3500m below surface. The FutureMine initiative was sub-divided into four broad streams of technological expertise: rock engineering and seismicity; mining engineering and orebody management; software and communications and ventilation, cooling and refrigeration. This paper presents a summary of research output in this last area of expertise. Broadly, research in mine ventilation, cooling and refrigeration was directed in areas related to the re-circulation of air, cyclical use of ventilation and cooling systems, air scrubbing technology, optimization of chilled water reticulation, obtaining direct cooling at the work-face, improving underground refrigeration system through dry air-cooling and water heat rejection systems and a number of software simulation programs to be used in specific applications and as a tool assisting real-time monitoring of underground environmental conditions. This paper describes in broad terms the outcomes from this section of the research programme and proposes ways in which some of these technologies may be combined synergistically in novel systems aimed at maintaining acceptable environmental conditions while reducing the impact on the profitability of operations.http://www.mvssa.co.zaam2017Mining Engineerin

The proline-rich peptide Bac7(1-35) reduces mortality from Salmonella typhimurium in a mouse model of infection

<p>Abstract</p> <p>Background</p> <p>Bac7 is a proline-rich peptide with a potent <it>in vitro </it>antimicrobial activity against Gram-negative bacteria. Here we investigated its activity in biological fluids and <it>in vivo </it>using a mouse model of <it>S. typhimurium </it>infection.</p> <p>Results</p> <p>The efficacy of the active 1-35 fragment of Bac7 was assayed in serum and plasma, and its stability in biological fluids analyzed by Western blot and mass spectrometry. The ability of the peptide to protect mice against <it>Salmonella </it>was assayed in a typhoid fever model of infection by determination of survival rates and bacterial load in liver and spleen of infected animals. In addition, the peptide's biodistribution was evaluated by using time-domain optical imaging. Bac7(1-35) retained a substantial <it>in vivo </it>activity showing a very low toxicity. The peptide increased significantly the number of survivors and the mean survival times of treated mice reducing the bacterial load in their organs despite its rapid clearance.</p> <p>Conclusions</p> <p>Our results provide a first indication for a potential development of Bac7-based drugs in the treatment of salmonellosis and, eventually, other Gram-negative infections. The <it>in vivo </it>activity for this peptide might be substantially enhanced by decreasing its excretion rate or modifying the treatment schedule.</p

Supporting hydrocarbon exploration in new venture areas with optical remote sensing

In past time, exploration geologists mainly used Earth Observation systems for basin-wide analysis of gravimetry, magnetomerty, structural faults, lithology and land-cover. After two decades of research, nowadays multispectral and hyperspectral remote sensing represent a cutting-edge technology in the oil and gas industry. The application fields of optical remote sensing not only range from the monitoring of the oilfields to the evaluation of pollution, but also to hydrocarbon exploration. With reference to exploration activities, the observation of the territory from above into several different wavelengths is able to supply inestimable geophysical information related to the microseepage effect, different and complementary to tradition geophysical methods. It is almost accepted that many of the oil and gas fields leak light hydrocarbon gases along nearly vertical pathways and, thus, their detection with multi/hyperspectral imaging can support the detection of active petroleum systems. Indeed, several independent oil companies are using satellite and airborne observations for reducing exploration risks in new venture areas and for optimizing their seismic surveys. This study shows some examples of microseepage-related geochemical and geobotanical alterations detected in several different environments, from sandy desert to vegetated savannah, both using airborne hyperspectral data and multispectral satellite time series. All the examples analyze real onshore concession blocks in Africa and Asia and results clearly show a correlation between the spectral signals recorded form remote with in situ measures, well logs, the knowledge of the subsurface and the position of known oilfields

Conjugated PDT drug: photosensitizing activity and tissue distribution of PEGylated pheophorbide a.

The design of new photosensitizers with enhanced phototoxicity and pharmacokinetic properties remains a central challenge for cancer photodynamic therapy (PDT). In this study, Pheophorbide a (Pba) has been pegylated to methoxypolyethylene glycol (mPE G-Pba) to produce a soluble photosensitizer that exhibits a higher tissue distribution than free Pba. In vitro studies have shown that mPE G-Pba promotes a fairly strong photosensitizing effect in cancer cells, as previously observed for the unpegylated molecule. mPE G-Pba targets the mitochondria where, following photoactivation, ROS are produced which cause a cellular injury by lipid peroxidation. The effect of pegylation on the photosensitizer biodistribution has been examined in different selected organs of female mice, at different time points after intraperitoneal administration of the drug (50 μmol/Kg body weight). Other than free Pba, which showed a low tissue accumulation, mPE G-Pba has been detected in significant amounts (8 to 16 μg/ml) in liver, spleen, duodenum and kidney and, 3-5 hours after intraperitoneal injection, in moderate amounts (3 to 8 μg/ml) in brain and lung. In vivo optical imaging performed on living female C57/BL6 mice bearing a subcutaneous melanoma mass, showed that injected mPEG-Pba distributes all over the body, with an higher uptake in the tumor respect to free Pba. Our results indicate that although pegylation somewhat decreases the phototoxicity, it significantly increases the drug solubility and tissue distribution and tumor uptake of mPE G-Pba, making the conjugate an interesting photosensitizer for PDT