A Computational Investigation of Cardiac Caveolae as a Source of Persistent Sodium Current

Recent studies of cholesterol-rich membrane microdomains, called caveolae, reveal that caveolae are reservoirs of “recruitable” sodium ion channels. Caveolar channels constitute a substantial and previously unrecognized source of sodium current in cardiac cells. In this paper we model for the first time caveolar sodium currents and their contributions to cardiac action potential morphology. We show that the β-agonist-induced opening of caveolae may have substantial impacts on peak overshoot, maximum upstroke velocity, and ultimately conduction velocity. Additionally, we show that prolonged action potentials and the formation of potentially arrhythmogenic afterdepolarizations, can arise if caveolae open intermittently throughout the action potential. Our simulations suggest that caveolar sodium current may constitute a route, which is independent of channelopathies, to delayed repolarization and the arrhythmias associated with such delays

Taille de la population d’Avahi laniger dans la réserve d’Ambodiriana-Manompana, Nord-est de Madagascar

Avahi laniger est le seul lémurien nocturne appartenant à la famille des Indriidae qui habite les forêts humides de l’est de Madagascar (Mittermeier et. al., 2010) dont une partie disparaît chaque année (exploitation du bois, pratique du «tavy» ou culture sur brûlis) (Beaucent and Fayolle, 2011; Lehman and Wright, 2000). La fragmentation et la destruction de leur habitat ainsi que la chasse menacent la survie de nombreuses espèces de lémuriens incluant celle de A. laniger (Jenkins et. al., 2011; Rakotondravony and Rabenandrasana, 2011; Anderson, Rowcliffe and Cowlishaw, 2007). Nous avons réalisé, entre fin Avril et Mai 2012, une étude de densité de la population de A. laniger au sein de l’aire protégée de Manompana-Ambodiriana afin d’estimer la taille de la population totale et de déterminer l’impact du projet de conservation menée par l’Association de Défense de la Forêt d’Ambodiriana (ADEFA) qui recherche l’évolution démographique à moyen terme de cette espèce."LABEX" TULIP: (ANR-10-LABX-41), fct fellowship: (SFRH/BD/64875/2009)

The isolation of gravitational instantons: Flat tori V flat R^4

The role of topology in the perturbative solution of the Euclidean Einstein equations about flat instantons is examined.Comment: 15 pages, ICN-UNAM 94-1

Stability of Horava-Lifshitz Black Holes in the Context of AdS/CFT

The anti--de Sitter/conformal field theory (AdS/CFT) correspondence is a powerful tool that promises to provide new insights toward a full understanding of field theories under extreme conditions, including but not limited to quark-gluon plasma, Fermi liquid and superconductor. In many such applications, one typically models the field theory with asymptotically AdS black holes. These black holes are subjected to stringy effects that might render them unstable. Ho\v{r}ava-Lifshitz gravity, in which space and time undergo different transformations, has attracted attentions due to its power-counting renormalizability. In terms of AdS/CFT correspondence, Ho\v{r}ava-Lifshitz black holes might be useful to model holographic superconductors with Lifshitz scaling symmetry. It is thus interesting to study the stringy stability of Ho\v{r}ava-Lifshitz black holes in the context of AdS/CFT. We find that uncharged topological black holes in $\lambda=1$ Ho\v{r}ava-Lifshitz theory are nonperturbatively stable, unlike their counterparts in Einstein gravity, with the possible exceptions of negatively curved black holes with detailed balance parameter $\epsilon$ close to unity. Sufficiently charged flat black holes for $\epsilon$ close to unity, and sufficiently charged positively curved black holes with $\epsilon$ close to zero, are also unstable. The implication to the Ho\v{r}ava-Lifshitz holographic superconductor is discussed.Comment: 15 pages, 6 figures. Updated version accepted by Phys. Rev. D, with corrections to various misprints. References update

Remarks on evolution of space-times in 3+1 and 4+1 dimensions

A large class of vacuum space-times is constructed in dimension 4+1 from hyperboloidal initial data sets which are not small perturbations of empty space data. These space-times are future geodesically complete, smooth up to their future null infinity, and extend as vacuum space-times through their Cauchy horizon. Dimensional reduction gives non-vacuum space-times with the same properties in 3+1 dimensions.Comment: 10pp, exposition improved; final versio

Complete Calabi-Yau metrics from Kahler metrics in D=4

In the present work the local form of certain Calabi-Yau metrics possessing a local Hamiltonian Killing vector is described in terms of a single non linear equation. The main assumptions are that the complex $(3,0)$-form is of the form $e^{ik}\widetilde{\Psi}$, where $\widetilde{\Psi}$ is preserved by the Killing vector, and that the space of the orbits of the Killing vector is, for fixed value of the momentum map coordinate, a complex 4-manifold, in such a way that the complex structure of the 4-manifold is part of the complex structure of the complex 3-fold. The link with the solution generating techniques of [26]-[28] is made explicit and in particular an example with holonomy exactly SU(3) is found by use of the linearization of [26], which was found in the context of D6 branes wrapping a holomorphic 1-fold in a hyperkahler manifold. But the main improvement of the present method, unlike the ones presented in [26]-[28], does not rely in an initial hyperkahler structure. Additionally the complications when dealing with non linear operators over the curved hyperkahler space are avoided by use of this method.Comment: Version accepted for publication in Phys.Rev.

Realizing a Deterministic Source of Multipartite-Entangled Photonic Qubits

Sources of entangled electromagnetic radiation are a cornerstone in quantum information processing and offer unique opportunities for the study of quantum many-body physics in a controlled experimental setting. While multi-mode entangled states of radiation have been generated in various platforms, all previous experiments are either probabilistic or restricted to generate specific types of states with a moderate entanglement length. Here, we demonstrate the fully deterministic generation of purely photonic entangled states such as the cluster, GHZ, and W state by sequentially emitting microwave photons from a controlled auxiliary system into a waveguide. We tomographically reconstruct the entire quantum many-body state for up to $N=4$ photonic modes and infer the quantum state for even larger $N$ from process tomography. We estimate that localizable entanglement persists over a distance of approximately ten photonic qubits, outperforming any previous deterministic scheme

Semi-classical stability of AdS NUT instantons

The semi-classical stability of several AdS NUT instantons is studied. Throughout, the notion of stability is that of stability at the one-loop level of Euclidean Quantum Gravity. Instabilities manifest themselves as negative eigenmodes of a modified Lichnerowicz Laplacian acting on the transverse traceless perturbations. An instability is found for one branch of the AdS-Taub-Bolt family of metrics and it is argued that the other branch is stable. It is also argued that the AdS-Taub-NUT family of metrics are stable. A component of the continuous spectrum of the modified Lichnerowicz operator on all three families of metrics is found.Comment: 18 pages, 3 figures; references adde

The Joint Crisis Plan: A Powerful Tool to Promote Mental Health.

Purpose: The Joint Crisis Plan (JCP) has received growing interest in clinical and research settings. JCP is a type of psychiatric advance statement that describes how to recognize early signs of crisis and how to manage crises. The purpose of the present study, to our knowledge the first to be conducted on this topic in the French-speaking context and to include inpatients, was to describe the content of JCPs and how they are perceived by patients and the providers. Methods: The study used an exploratory, mixed, sequential method. Existing JCPs were retrospectively collected in several clinical contexts (hospital, community settings, and sheltered accommodation). Based on their analyses, we conducted semi-structured interviews including some rating scales on the perception of the JCPs among patients and providers in these settings. For the qualitative analyses, content analyses were conducted with a hybrid approach using NVivo 12 software. Data were double-coded and discussed with a third researcher until agreement was reached. Results: One hundred eighty-four JCPs were collected retrospectively and 24 semi-structured interviews were conducted with 12 patients and 12 providers. No relatives could be included in the research process. The content of the studied JCPs was relevant and indicated that patients had good knowledge of themselves and their illness. Improvements in the quality of the therapeutic relationship, respect for patients' choices and wishes, and a greater sense of control of their illness were reported. The JCP was perceived as a very useful tool by patients and providers. Concerning JCP limitations, lack of staff training, difficulties with the shared decision-making process, and the poor availability of the JCPs when needed were reported. Conclusion: The study highlights that JCPs may be used with patients suffering from a large variety of psychiatric disorders in different care settings. The JCP is perceived as very useful by both patients and providers. The promising results of this study support the promotion of the wide use of JCPs with patients who have experienced crises. It is important to continue to research JCPs through impact studies that include family members

Maximum solutions of normalized Ricci flows on 4-manifolds

We consider maximum solution $g(t)$, $t\in [0, +\infty)$, to the normalized Ricci flow. Among other things, we prove that, if $(M, \omega)$ is a smooth compact symplectic 4-manifold such that $b_2^+(M)>1$ and let $g(t),t\in[0,\infty)$, be a solution to (1.3) on $M$ whose Ricci curvature satisfies that $|\text{Ric}(g(t))|\leq 3$ and additionally $\chi(M)=3 \tau (M)>0$, then there exists an $m\in \mathbb{N}$, and a sequence of points $\{x_{j,k}\in M\}$, $j=1, ..., m$, satisfying that, by passing to a subsequence, $$(M, g(t_{k}+t), x_{1,k},..., x_{m,k}) \stackrel{d_{GH}}\longrightarrow (\coprod_{j=1}^m N_j, g_{\infty}, x_{1,\infty}, ...,, x_{m,\infty}),$$ $t\in [0, \infty)$, in the $m$-pointed Gromov-Hausdorff sense for any sequence $t_{k}\longrightarrow \infty$, where $(N_{j}, g_{\infty})$, $j=1,..., m$, are complete complex hyperbolic orbifolds of complex dimension 2 with at most finitely many isolated orbifold points. Moreover, the convergence is $C^{\infty}$ in the non-singular part of $\coprod_1^m N_{j}$ and $\text{Vol}_{g_{0}}(M)=\sum_{j=1}^{m}\text{Vol}_{g_{\infty}}(N_{j})$, where $\chi(M)$ (resp. $\tau(M)$) is the Euler characteristic (resp. signature) of $M$.Comment: 23 page