Sudesna mjerenja γγ-raspada stanja 166Ho nastalih reakcijom (n,γ)

Levels of 166Ho were studied using thermal and average resonance neutron capture and with the (d,p) and (d,3He) reactions. We have devoted a large effort to the measurements of the γγ-coincidence spectra in the broad energy region 50 - 6243 keV. Based on these data and those of earlier studies, the levels are grouped into 23 rotational bands. Among them are 6 new ones. The results are in good agreement with the semiempirical and quasiparticle-phonon model, where Coriolis and residual interactions are taken into account. Details of model interpretation have been presented in a previously published paper.Proučavali smo stanja 166Ho nastala termičkim i prosječnim rezonantnim uhvatom neutrona, te (d,p) i (d,3He) reakcijama. Uložili smo velik trud u mjerenjima sudesnih γγ-spektara u širokom energijskom području od 50 do 6243 keV. Na osnovi tih i ranijih podataka, stanja su grupirana u 23 rotacijske vrpce. Među njima je i 6 novih. Ishodi su u suglasju s poluempiričkim i kvazičestično-fononskim modelom, uzimajući u obzir Coriolisovo međudjelovanje i rezidualne interakcije. Podrobnosti modelskog tumačenja objavljene u u ranijem članku

Differential antitumor immunity mediated by NKT cell subsets in vivo

We showed previously that NKT cell–deficient TCR Jα18(−/−) mice are more susceptible to methylcholanthrene (MCA)-induced sarcomas, and that normal tumor surveillance can be restored by adoptive transfer of WT liver-derived NKT cells. Liver-derived NKT cells were used in these studies because of their relative abundance in this organ, and it was assumed that they were representative of NKT cells from other sites. We compared NKT cells from liver, thymus, and spleen for their ability to mediate rejection of the sarcoma cell line (MCA-1) in vivo, and found that this was a specialized function of liver-derived NKT cells. Furthermore, when CD4(+) and CD4(−) liver-derived NKT cells were administered separately, MCA-1 rejection was mediated primarily by the CD4(−) fraction. Very similar results were achieved using the B16F10 melanoma metastasis model, which requires NKT cell stimulation with α-galactosylceramide. The impaired ability of thymus-derived NKT cells was due, in part, to their production of IL-4, because tumor immunity was clearly enhanced after transfer of IL-4–deficient thymus-derived NKT cells. This is the first study to demonstrate the existence of functionally distinct NKT cell subsets in vivo and may shed light on the long-appreciated paradox that NKT cells function as immunosuppressive cells in some disease models, whereas they promote cell-mediated immunity in others

Supporting patients experiencing poverty-related mental distress: development and evaluation of a training resource in general practices in eleven regions of England

This is the final version. Available from Elsevier via the DOI in this record. National Institute for Health Researc

Phase appearance or disappearance in two-phase flows

This paper is devoted to the treatment of specific numerical problems which appear when phase appearance or disappearance occurs in models of two-phase flows. Such models have crucial importance in many industrial areas such as nuclear power plant safety studies. In this paper, two outstanding problems are identified: first, the loss of hyperbolicity of the system when a phase appears or disappears and second, the lack of positivity of standard shock capturing schemes such as the Roe scheme. After an asymptotic study of the model, this paper proposes accurate and robust numerical methods adapted to the simulation of phase appearance or disappearance. Polynomial solvers are developed to avoid the use of eigenvectors which are needed in usual shock capturing schemes, and a method based on an adaptive numerical diffusion is designed to treat the positivity problems. An alternate method, based on the use of the hyperbolic tangent function instead of a polynomial, is also considered. Numerical results are presented which demonstrate the efficiency of the proposed solutions

Proučavanje 194Ir uhvatom termičkih neutrona I (d, p) reakcijom

Levels of 194Ir were studied using thermal neutron capture reaction. A pair spectrometer was used to measure the high-energy γ-ray spectrum from thermal-neutron capture in enriched 193Ir target over the energy range 4640 - 6100 keV. The low-energy γ-radiation from the reaction was studied with crystal diffraction spectrometers, and conversion electrons were observed with magnetic spectrometers. The high-sensitivity measurements at the Grenoble reactor, evaluated for transition energies up to 500 keV, are compared with lower-sensitivity measurements at the Wuerenlingen and Salaspils reactors. The comparison helped to obtain reliable isotopic identification for a number of 194Ir lines. The multipolarity admixtures for 29 γ-transitions were determined on the basis of conversion lines from different electron subshells. Prompt and delayed γ-γ coincidences were measured using semiconductor and scintillation detectors. The 193Ir(d,p) high-resolution spectra, observed with a magnetic spectrometer, are given. All these data contributed to establishing a detailed level scheme of 194Ir. Additional data and the interpretation of the results in terms of current models will be presented in a forthcoming paper.Proučavala su se stanja u 194Ir reakcijama 193Ir(n, γ) i 193Ir(d, p). Mjerenja uhvata termičkih neutrona načinjena su uz reaktore u Grenoblu, Wuerenlingenu i Salapsisu. Za mjerenja γ-zračenja visoke energije upotrebljavao se spektrometar parova, a za niske energije difraktometar. Konverzijske elektrone se mjerilo magnetskim spektrometrom. Mjerenja reakcije (d, p) visokog razlučivanja izvedena su magnetskim spektrometrom. Usporedbe tih mjerenja omogućile su pouzdano izotopno prepoznavanje prijelaza u 194 Ir, a spektri konverzijskih elektrona i određivanje multipolnosti prijelaza. Dobiveni su podaci osnova sheme raspada 194Ir

Study of ^194 Ir via thermal neutron capture and (d,p) reactions

Levels of ^194 Ir were studied using thermal neutron capture reaction. A pair spectrometer was used to measure the high-energy gamma-ray spectrum from thermal-neutron capture in enriched ^193 Ir target over the energy range 4640 - 6100 keV. The low-energy gamma-radiation from the reaction was studied with crystal diffraction spectrometers, and conversion electrons were observed with magnetic spectrometers. The high-sensitivity measurements at the Grenoble reactor, evaluated for transition energies up to 500 keV, are compared with lower-sensitivity measurements at the Wuerenlingen and Salaspils reactors. The comparison helped to obtain reliable isotopic identification for a number of ^194 Ir lines. The multipolarity admixtures for 29 gamma-transitions were determined on the basis of conversion lines from different electron subshells. Prompt and delayed gamma-gamma coincidences were measured using semiconductor and scintillation detectors. The ^193 Ir(d,p) high-resolution spectra, observed with a magnetic spectrometer, are given. All these data contributed to establishing a detailed level scheme of ^194 Ir. Additional data and the interpretation of the results in terms of current models will be presented in a forthcoming paper

Associations of T cell activation and inflammatory biomarkers with virological response to darunavir/ritonavir plus raltegravir therapy

One of the goals of antiretroviral therapy (ART) is to attenuate HIV-induced systemic immune activation and inflammation. We determined the dynamics of biomarkers of immune activation, microbial translocation and inflammation during initial ART with a nucleos(t)ide-sparing regimen of darunavir/ritonavir plus raltegravir. We also evaluated associations between these biomarkers and the virological response to the regimen