422 research outputs found

    Plasmon and grid resonances in the electromagnetic scattering by finite grids of silver nanowires

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    The problem of the H-polarized wave scattering by finite chains of circular nanowires is considered. A two-dimensional diffraction problem with rigorous boundary conditions is solved by partial separations of variables method using local polar coordinates of each scatterer. The obtained results demonstrate convergence of the algorithm and good agreement with data known for the conducting and dielectric cylinders. Plasmonic and grid resonances are found and calculated for grids from a big number of silver nanowires. This opens a way to the accurate numerical simulation of various finite configurations of wires met in today's nano and microsize photonic devices. © 2010 IEEE

    Enhancement of plasmon resonances in the wave scattering by finite grids of circular silver wires

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    Using the field expansions in local coordinates and addition theorems for cylindrical functions, we consider the problem of the H-polarized plane wave scattered by a finite chain of circular wires. The absorption and scattering cross-sections are found numerically and plasmon and grating-type resonances are studied for the grids of silver nano-size wires. © 2010 IEEE

    Resonances in the electromagnetic scattering by very large finite-periodic grids of circular dielectric wires

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    Diffraction of plane waves by infinite gratings is a classical research topic in the scattering theory. Using the Floquet theorem, one can reduce the infinite grating problem to the one-period problem. A characteristic feature of infinite-grating scattering is the drastic transformation of the scattering pattern and reflectance intensity if, in the process of changing the frequency or the angle of incidence, one of the Floquet harmonics is "passing over horizon." This phenomenon was first explained by Rayleigh [1] who studied theoretically the "anomalies" discovered experimentally by Wood [2]. In the simplest case of the normal incidence, these Rayleigh-Wood anomalies are observed if the period of the grating is multiple to the wavelength. © 2010 IEEE

    Aldehyde dehydrogenase-1a1 induces oncogene suppressor genes in B cell populations

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    AbstractThe deregulation of B cell differentiation has been shown to contribute to autoimmune disorders, hematological cancers, and aging. We provide evidence that the retinoic acid-producing enzyme aldehyde dehydrogenase 1a1 (Aldh1a1) is an oncogene suppressor in specific splenic IgG1+/CD19− and IgG1+/CD19+ B cell populations. Aldh1a1 regulated transcription factors during B cell differentiation in a sequential manner: 1) retinoic acid receptor alpha (Rara) in IgG1+/CD19− and 2) zinc finger protein Zfp423 and peroxisome proliferator-activated receptor gamma (Pparg) in IgG1+/CD19+ splenocytes. In Aldh1a1−/− mice, splenic IgG1+/CD19− and IgG1+/CD19+ B cells acquired expression of proto-oncogenic genes c-Fos, c-Jun, and Hoxa10 that resulted in splenomegaly. Human multiple myeloma B cell lines also lack Aldh1a1 expression; however, ectopic Aldh1a1 expression rescued Rara and Znf423 expressions in these cells. Our data highlight a mechanism by which an enzyme involved in vitamin A metabolism can improve B cell resistance to oncogenesis

    Genomic Deletion Marking an Emerging Subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula

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    P. 7465-7470Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian PeninsulaS

    Implementation of a pharmacogenomics consult service to support the INGENIOUS trial

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    Hospital systems increasingly utilize pharmacogenomic testing to inform clinical prescribing. Successful implementation efforts have been modeled at many academic centers. In contrast, this report provides insights into the formation of a pharmacogenomics consultation service at a safety-net hospital, which predominantly serves low-income, uninsured, and vulnerable populations. The report describes the INdiana GENomics Implementation: an Opportunity for the UnderServed (INGENIOUS) trial and addresses concerns of adjudication, credentialing, and funding
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