Prolonged Chronic Graft-versus-Host Disease is a Risk Factor for Thyroid Failure in Long-Term Survivors After Matched Sibling Donor Stem Cell Transplantation for Hematologic Malignancies

AbstractWe studied thyroid function in 81 long-term survivors of allogeneic stem cell transplantation (allo-SCT), with a median follow-up of 84 months (range, 45 to 166 months). Median age at transplantation was 35 years (range, 6 to 66). Seventy-two of the patients received a total body irradiation (TBI)–containing conditioning regimen (n = 23, 12 Gy; n = 49, 13 Gy). Twenty-one of the patients (25.9%) had subclinical hypothyroidism, and 9 (11.1%) developed overt hypothyroidism at a median of 28 months (range, 3 to 78 months) after allo-SCT. Multivariate logistic regression analysis demonstrated that prolonged immunosuppressive therapy (IST) was significantly associated with subclinical hypothyroidism (odds ratio [OR] = 3.8) and overt hypothyroidism (OR = 2.6). Antithyroglobulin and thyroid peroxidase antibody were detected in 12 of 60 patients tested (20%). No correlation was found between the occurrence of thyroid antibodies and hypothyroidism (P = .13) or chronic graft-versus-host disease (cGVHD) (P = .55). In conclusion, thyroid dysfunction is relatively common after allo-SCT and is more likely to occur in patients receiving prolonged IST for cGVHD; however, thyroid dysfunction does not appear to be related to an antibody-mediated autoimmune process

Measuring the decoherence rate in a semiconductor charge qubit

We describe a method by which the decoherence time of a solid state qubit may be measured. The qubit is coded in the orbital degree of freedom of a single electron bound to a pair of donor impurities in a semiconductor host. The qubit is manipulated by adiabatically varying an external electric field. We show that, by measuring the total probability of a successful qubit rotation as a function of the control field parameters, the decoherence rate may be determined. We estimate various system parameters, including the decoherence rates due to electromagnetic fluctuations and acoustic phonons. We find that, for reasonable physical parameters, the experiment is possible with existing technology. In particular, the use of adiabatic control fields implies that the experiment can be performed with control electronics with a time resolution of tens of nanoseconds.Comment: 9 pages, 6 figures, revtex

Synthesis of pentacene nanotubes by melt-assisted template wetting

peer-reviewedno abstract availablePUBLISHEDpeer-reviewe

Spin instabilities and quantum phase transitions in integral and fractional quantum Hall states

The inter-Landau-level spin excitations of quantum Hall states at filling factors nu=2 and 4/3 are investigated by exact numerical diagonalization for the situation in which the cyclotron (hbar*omega_c) and Zeeman (E_Z) splittings are comparable. The relevant quasiparticles and their interactions are studied, including stable spin wave and skyrmion bound states. For nu=2, a spin instability at a finite value of epsilon=hbar*omega_c-E_Z leads to an abrupt paramagnetic to ferromagnetic transition, in agreement with the mean-field approximation. However, for nu=4/3 a new and unexpected quantum phase transition is found which involves a gradual change from paramagnetic to ferromagnetic occupancy of the partially filled Landau level as epsilon is decreased.Comment: 4 pages, 5 figures, submitted to Phys.Rev.Let

North Atlantic marine ¹⁴C reservoir effects: implications for late-Holocene chronological studies

We investigated surface ocean–atmosphere 14C offsets for the later Holocene at eight locations in the eastern North Atlantic. This resulted in 11 new ΔR assessments for the west coast of Ireland, the Outer Hebrides, the north coast of the Scottish mainland, the Orkney Isles and the Shetland Isles over the period 1300–500 BP. Assessments were made using a robust Multiple Paired Sample (MPS) approach, which is designed to maximize the accuracy of ΔR determinations. Assessments are placed in context with other available data to enable reconstruction of a realistic picture of surface ocean 14C activity over the Holocene period within the North Atlantic region

Noncommutative Geometry, Extended W(infty) Algebra and Grassmannian Solitons in Multicomponent Quantum Hall Systems

Noncommutative geometry governs the physics of quantum Hall (QH) effects. We introduce the Weyl ordering of the second quantized density operator to explore the dynamics of electrons in the lowest Landau level. We analyze QH systems made of $N$-component electrons at the integer filling factor $\nu=k\leq N$. The basic algebra is the SU(N)-extended W$_{\infty}$. A specific feature is that noncommutative geometry leads to a spontaneous development of SU(N) quantum coherence by generating the exchange Coulomb interaction. The effective Hamiltonian is the Grassmannian $G_{N,k}$ sigma model, and the dynamical field is the Grassmannian $G_{N,k}$ field, describing $k(N-k)$ complex Goldstone modes and one kind of topological solitons (Grassmannian solitons).Comment: 15 pages (no figures

Axisymmetric versus Non-axisymmetric Vortices in Spinor Bose-Einstein Condensates

The structure and stability of various vortices in F=1 spinor Bose-Einstein condensates are investigated by solving the extended Gross-Pitaevskii equation under rotation. We perform an extensive search for stable vortices, considering both axisymmetric and non-axisymmetric vortices and covering a wide range of ferromagnetic and antiferromagnetic interactions. The topological defect called Mermin-Ho (Anderson-Toulouse) vortex is shown to be stable for ferromagnetic case. The phase diagram is established in a plane of external rotation Omega vs total magnetization M by comparing the free energies of possible vortices. It is shown that there are qualitative differences between axisymmetric and non-axisymmetric vortices which are manifested in the Omega- and M-dependences.Comment: 9 pages, 9 figure

Information Invariance and Quantum Probabilities

We consider probabilistic theories in which the most elementary system, a two-dimensional system, contains one bit of information. The bit is assumed to be contained in any complete set of mutually complementary measurements. The requirement of invariance of the information under a continuous change of the set of mutually complementary measurements uniquely singles out a measure of information, which is quadratic in probabilities. The assumption which gives the same scaling of the number of degrees of freedom with the dimension as in quantum theory follows essentially from the assumption that all physical states of a higher dimensional system are those and only those from which one can post-select physical states of two-dimensional systems. The requirement that no more than one bit of information (as quantified by the quadratic measure) is contained in all possible post-selected two-dimensional systems is equivalent to the positivity of density operator in quantum theory.Comment: 8 pages, 1 figure. This article is dedicated to Pekka Lahti on the occasion of his 60th birthday. Found. Phys. (2009

An Invitation to Higher Gauge Theory

In this easy introduction to higher gauge theory, we describe parallel transport for particles and strings in terms of 2-connections on 2-bundles. Just as ordinary gauge theory involves a gauge group, this generalization involves a gauge '2-group'. We focus on 6 examples. First, every abelian Lie group gives a Lie 2-group; the case of U(1) yields the theory of U(1) gerbes, which play an important role in string theory and multisymplectic geometry. Second, every group representation gives a Lie 2-group; the representation of the Lorentz group on 4d Minkowski spacetime gives the Poincar\'e 2-group, which leads to a spin foam model for Minkowski spacetime. Third, taking the adjoint representation of any Lie group on its own Lie algebra gives a 'tangent 2-group', which serves as a gauge 2-group in 4d BF theory, which has topological gravity as a special case. Fourth, every Lie group has an 'inner automorphism 2-group', which serves as the gauge group in 4d BF theory with cosmological constant term. Fifth, every Lie group has an 'automorphism 2-group', which plays an important role in the theory of nonabelian gerbes. And sixth, every compact simple Lie group gives a 'string 2-group'. We also touch upon higher structures such as the 'gravity 3-group' and the Lie 3-superalgebra that governs 11-dimensional supergravity.Comment: 60 pages, based on lectures at the 2nd School and Workshop on Quantum Gravity and Quantum Geometry at the 2009 Corfu Summer Institut

Global warming and the cosmopolitan political conception of justice

Within the literature in green political theory on global environmental threats one can often find dissatisfaction with liberal theories of justice. This is true even though liberal cosmopolitans regularly point to global environmental problems as one reason for expanding the scope of justice beyond the territorial limits of the state. One of the causes for scepticism towards liberal approaches is that many of the most notable anti-cosmopolitan theories are also advanced by liberals. In this paper, I first explain why one of the strongest expressions of liberal anti-cosmopolitanism cannot simply be dismissed because it may fail to support desired environmental ends. The political conception of justice represents one of the most important challenges to cosmopolitanism generally and is thus a serious challenge to viewing global environmental problems in terms of cosmopolitan justice. Second, I will show through the case of anthropogenic global warming that the political conception of justice under current conditions does have clear cosmopolitan implications despite its proponents' claims