Percolation study for the capillary ascent of a liquid through a granular soil

Capillary rise plays a crucial role in the construction of road embankments in flood zones, where hydrophobic compounds are added to the soil to suppress the rising of water and avoid possible damage of the pavement. Water rises through liquid bridges, menisci and trimers, whose width and connectivity depends on the maximal half-length {\lambda} of the capillary bridges among grains. Low {\lambda} generate a disconnect structure, with small clusters everywhere. On the contrary, for high {\lambda}, create a percolating cluster of trimers and enclosed volumes that form a natural path for capillary rise. Hereby, we study the percolation transition of this geometric structure as a function of {\lambda} on a granular media of monodisperse spheres in a random close packing. We determine both the percolating threshold {\lambda}_{c} = (0.049 \pm 0.004)R (with R the radius of the granular spheres), and the critical exponent of the correlation length {\nu} = (0.830 \pm 0.051), suggesting that the percolation transition falls into the universality class of ordinary percolation

Going beyond telecenters to foster the digital inclusion of older people in Brazil: lessons learned from a rapid ethnographical study

Telecenters take on a prominent role within the current information and communications technology (ICT) ecosystem in Brazil. They are seen by a great many as a key means to foster the digital inclusion of the older population in the country. This paper draws upon a rapid ethnographic study conducted with 78 older people in a center that teaches computer classes to seniors in Brazil. The results show that providing older people with technological infrastructures is not enough to strengthen their digital inclusion if their basic and non-instrumental needs are not taken into consideration in defining educational activities to be carried out in public centers. Participants’ basic needs when it comes to interacting with ICT, such as coping with accessibility issues, were dynamic, whilst non-instrumental needs, fulfilled by using these technologies, such as interacting with relevant others, remained fairly constant throughout the study. Drawing on the results of the study, strategies for fostering the digital inclusion and well-being of older people in Brazil that go beyond telecenters are suggested

The role of nicotinic cholinergic neurotransmission in delusional thinking

Delusions are a difficult-to-treat and intellectually fascinating aspect of many psychiatric illnesses. Although scientific progress on this complex topic has been challenging, some recent advances focus on dysfunction in neural circuits, specifically in those involving dopaminergic and glutamatergic neurotransmission. Here we review the role of cholinergic neurotransmission in delusions, with a focus on nicotinic receptors, which are known to play a part in some illnesses where these symptoms appear, including delirium, schizophrenia spectrum disorders, bipolar disorder, Parkinson, Huntington, and Alzheimer diseases. Beginning with what we know about the emergence of delusions in these illnesses, we advance a hypothesis of cholinergic disturbance in the dorsal striatum where nicotinic receptors are operative. Striosomes are proposed to play a central role in the formation of delusions. This hypothesis is consistent with our current knowledge about the mechanism of action of cholinergic drugs and with our abstract models of basic cognitive mechanisms at the molecular and circuit levels. We conclude by pointing out the need for further research both at the clinical and translational levels.Fil: Caton, Michael. No especifíca;Fil: Ochoa, Enrique L. M.. University of California at Davis; Estados UnidosFil: Barrantes, Francisco Jose. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentin

Early hospital readmissions post‐kidney transplantation are associated with inferior clinical outcomes

Unplanned hospital readmissions are common early post‐kidney transplantation. We investigated the relationship between early hospital readmissions and clinical outcomes in a single‐center retrospective study that included all adult kidney transplant patients between 2004 and 2008 with follow‐up to December 2012. The early hospital readmissions within the first 30 d were numbered and the diagnosis ascertained. Patients were grouped as none, once, and twice or more readmissions. Predictors of early readmissions were assessed, and clinical outcomes and patient and death‐censored kidney survival were compared. Among 1064 patients, 203 (19.1%) patients had once and 83 (7.8%) patients had twice or more readmissions within 30 d. Surgical complications, infections, and acute kidney injuries/acute rejection were three most common diagnoses. The length of initial hospital stay and African American race were among the variables associated significantly with readmissions. Patients with early readmissions had lower baseline renal function (p < 0.01) and more early acute rejection (p < 0.01). During follow‐up, only frequent readmissions, twice or more, within 30 d were associated with increased risk of death ( AHR 1.75, p   =   0.01) and death‐censored kidney failure ( AHR 2.20, p < 0.01). Frequent early hospital readmissions post‐transplantation identify patients at risk for poor long‐term outcomes, and more studies are needed to understand the mechanisms.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106830/1/ctr12347.pd

Perceibed Barriers to the Integration of TIC for Preschool and Primary Teachers in Extremadura

Este artículo, parte de un trabajo de investigación mucho más amplio, presenta las barreras percibidas en la integración de las TIC en educación por los profesores de Infantil y Primaria de Extremadura. Los resultados obtenidos mediante análisis factorial a partir de los datos de una muestra de 567 profesores, indican que los principales obstáculos son la falta de tiempo, la falta de competencia, y la falta de ordenadores en el aula. Hemos identificado también tres dimensiones que hemos denominado obstáculos de infraestructuras y materiales, obstáculos de formación y obstáculos de organización y currículo.This article, part of a much broader research, aims to present the perceived barriers to the integration of ICT in education by preschool and primaryteachers of the Autonomous Community of Extremadura (Spain). The results obtained by factor analysis of data from a sample of 567 teachers, indicate that for them, the main obstacles are lack of time, lack of competence, and lack of computers in the classroom. We have also identified three dimensions that we call infrastructure and material barriers, training barriers and curriculum and organization barriers

Isolation of modulators of Organic Anion Transporting Polypeptides (OATPs) from Rollinia emarginata Schlecht (Annonaceae)

Comparative Medicine - OneHealth and Comparative Medicine Poster SessionOrganic Anion Transporting Polypeptides (OATPs) comprise a superfamily of sodium-independent membrane transporters which are involved in transporting numerous endogenous and exogenous substances. OATPs are expressed in different tissues such as intestine, liver, kidney and brain, and are responsible for the uptake of important drugs including cholesterol-lowering agents (statins), endothelin receptor antagonists (sartans), the anticancer drugs methotrexate, SN-38, paclitaxel and docetaxel, as well as the antibiotic rifampicin. Through a strategic collaboration, we search for novel small molecules from the organic extract of Rollinia emarginata Schlecht. (Annonaceae) that interact with the liver specific OATP1B1 and OATP1B3 applying a bioassay guided isolation approach. The organic extract was fractionated using different chromatographic techniques, and each fraction was tested for its effect on OATP1B1- and OATP1B3-mediated transport of 1µM estrone-3-sulfate and 0.1µM estradiol-17||-glucuronide. Several inhibitors, including both substrate-specific and non-specific, were isolated and chemically identified. For instance, the compound Quercetin 3-O-||-L-arabinopyranosyl (1 ->2)||-L-rhamnopyranoside was shown to inhibit both OATP1B1- and OATP1B3-mediated transport of estradiol-17||-glucuronide by more than 90%, relative to control (DMSO). However, with respect to transport of 1µM estrone-3-sulfate it inhibits OATP1B1 by only 45% while, interestingly, stimulating transport mediated by OATP1B3 (2 fold over control). Thanks to our collaborative efforts, we were able to show that plants can be suitable source of small molecules that modulate OATPs using bioassay guided isolation approach

Interview investigation of insecure attachment styles as mediators between poor childhood care and schizophrenia-spectrum phenomenology

Background Insecure attachment styles have received theoretical attention and some initial empirical support as mediators between childhood adverse experiences and psychotic phenomena; however, further specificity needs investigating. The present interview study aimed to examine (i) whether two forms of poor childhood care, namely parental antipathy and role reversal, were associated with subclinical positive and negative symptoms and schizophrenia-spectrum personality disorder (PD) traits, and (ii) whether such associations were mediated by specific insecure attachment styles. Method A total of 214 nonclinical young adults were interviewed for subclinical symptoms (Comprehensive Assessment of At-Risk Mental States), schizophrenia-spectrum PDs (Structured Clinical Interview for DSM-IV Axis II Disorders), poor childhood care (Childhood Experience of Care and Abuse Interview), and attachment style (Attachment Style Interview). Participants also completed the Beck Depression Inventory-II and all the analyses were conducted partialling out the effects of depressive symptoms. Results Both parental antipathy and role reversal were associated with subclinical positive symptoms and with paranoid and schizotypal PD traits. Role reversal was also associated with subclinical negative symptoms. Angry-dismissive attachment mediated associations between antipathy and subclinical positive symptoms and both angry-dismissive and enmeshed attachment mediated associations of antipathy with paranoid and schizotypal PD traits. Enmeshed attachment mediated associations of role reversal with paranoid and schizotypal PD traits. Conclusions Attachment theory can inform lifespan models of how adverse developmental environments may increase the risk for psychosis. Insecure attachment provides a promising mechanism for understanding the development of schizophrenia-spectrum phenomenology and may offer a useful target for prophylactic intervention

Avaliação de impactos ambientais de diferentes sistemas de produção de cana-de-açúcar: convencional e conservacionista.

Resumo: O setor sucroenergético brasileiro é responsável pela produção anual de mais de 38 milhões de toneladas de açúcar e cerca de 27 bilhões de litros de etanol. A pressão social por práticas ambientalmente mais aceitáveis tem levado o setor a modificar seu atual sistema de produção. Neste contexto de mudança se inclui a interrupção da queima pré-colheita, que por sua vez possibilita a adoção de técnicas já consolidadas em outros setores agrícolas, como o plantio direto. O objetivo deste trabalho foi comparar o desempenho ambiental de dois sistemas de cultivo de cana-de-açúcar, convencional e plantio direto em rotação com soja, especificamente quanto às etapas de pré-plantio e plantio. Ambos os sistemas foram empregados em uma usina paulista, localizada em área tradicional, mas sob bioma de cerrado. Os resultados mostraram que o sistema convencional implica em maior impacto na categoria "Mudanças Climáticas", e o de plantio direto na "Depleção Fóssil". Contudo, observou-se um melhor desempenho do sistema conservacionista, que agrega um produto adicional (e que apresenta menor carga ambiental), com amesma ocupação de terras. Conclui-se que é de extrema importância a busca por práticas agrícolas mais sustentáveis na cultura canavieira, que já começa a mostrar resultados positivos

Avaliação do ciclo de vida da produção de algodão em dois sistemas de rotação de culturas.

Resumo: Os nanomateriais, por suas propriedades físico-químicas únicas, podem estabelecer interações imprevistas com substâncias naturalmente presentes nos componentes ambientais, fazendo-se indispensável a avaliação dos seus potenciais impactos ambientais. O objetivo deste trabalho foi avaliar a contribuição da fase agrícola da produção de algodão - matéria-prima para obtenção de nanomateriais ? no desempenho ambiental desta tecnologia. Consideraram-se dois sistemas de produção de algodão por plantio direto: em rotação com o milheto e em rotação com soja e capim Mombaça. O método adotado foi a Avaliação do Ciclo de Vida (ACV). Para ambos os sistemas, a fase mais impactante foi a produção agrícola de algodão, de modo que para o sistema em rotação com o milheto, maiores efeitos foram encontrados nas categorias de impacto de mudanças climáticas; ecotoxicidade aquática e terrestre; e toxicidade humana. Para o sistema em rotação com soja e capim, os impactos ambientais mais relevantes foram eutrofização de água doce e mudanças climáticas. Notou-se ainda que a soja, pelo fato de ser uma cultura beneficiada pelas bactérias fixadoras de nitrogênio, diminui o aporte de fertilizantes nitrogenados, reduzindo os impactos ambientais decorrentes da sua produção

Resolution of complex fluorescence spectra of lipids and nicotinic acetylcholine receptor by multivariate analysis reveals protein-mediated effects on the receptor's immediate lipid microenvironment

Analysis of fluorescent spectra from complex biological systems containing various fluorescent probes with overlapping emission bands is a challenging task. Valuable information can be extracted from the full spectra, however, by using multivariate analysis (MA) of measurements at different wavelengths. We applied MA to spectral data of purified Torpedo nicotinic acetylcholine receptor (AChR) protein reconstituted into liposomes made up of dioleoylphosphatidic acid (DOPA) and dioleoylphosphatidylcholine (DOPC) doped with two extrinsic fluorescent probes (NBD-cholesterol/pyrene-PC). Förster resonance energy transfer (FRET) was observed between the protein and pyrene-PC and between pyrene-PC and NBD-cholesterol, leading to overlapping emission bands. Partial least squares analysis was applied to fluorescence spectra of pyrene-PC in liposomes with different DOPC/DOPA ratios, generating a model that was tested by an internal validation (leave-one-out cross-validation) and was further used to predict the apparent lipid molar ratio in AChR-containing samples. The values predicted for DOPA, the lipid with the highest Tm, indicate that the protein exerts a rigidifying effect on its lipid microenvironment. A similar conclusion was reached from excimer formation of pyrene-PC, a collisional-dependent phenomenon. The excimer/monomer ratio (E/M) at different DOPC/DOPA molar ratios revealed the restricted diffusion of the probe in AChR-containing samples in comparison to pure lipid samples devoid of protein. FRET from the AChR (donor) to pyrene-PC (acceptor) as a function of temperature was found to increase with increasing temperature, suggesting a shorter distance between AChR and pyrene PC. Taken together, the results obtained by MA on complex spectra indicate that the AChR rigidifies its surrounding lipid and prefers DOPA rather than DOPC in its immediate microenvironment