567 research outputs found

    Scalar field description of a parametric model of dark energy

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    We investigate theoretical and observational aspects of a time-dependent parameterization for the dark energy equation of state (EoS) w(z)w(z), which is a well behaved function of the redshift zz over the entire cosmological evolution, i.e., z∈[−1,∞)z \in [-1,\infty). By using a theoretical algorithm of constructing the quintessence potential directly from the effective EoS parameter, we derive and discuss the general features of the resulting potential for this w(z)w(z) function. Since the parameterization here discussed allows us to divide the parametric plane in defined regions associated to distinct classes of dark energy models, we use the most recent observations from type Ia supernovae, baryon acoustic oscillation peak and Cosmic Microwave Background shift parameter to check which class is observationally prefered. We show that the largest portion of the confidence contours lies into the region corresponding to a possible crossing of the so-called phanton divide line at some point of the cosmic evolution.Comment: 5 pages, 2 figures, LaTe

    Predictive Criteria to Study the Pathogenesis of Malaria-Associated ALI/ARDS in Mice

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    Malaria-associated acute lung injury/acute respiratory distress syndrome (ALI/ARDS) often results in morbidity and mortality. Murine models to study malaria-associated ALI/ARDS have been described; we still lack a method of distinguishing which mice will develop ALI/ARDS before death. This work aimed to characterize malaria-associated ALI/ARDS in a murine model and to demonstrate the first method to predict whether mice are suffering from ALI/ARDS before death. DBA/2 mice infected with Plasmodium berghei ANKA developing ALI/ARDS or hyperparasitemia (HP) were compared using histopathology, PaO2 measurement, pulmonary X-ray, breathing capacity, lung permeability, and serum vascular endothelial growth factor (VEGF) levels according to either the day of death or the suggested predictive criteria. We proposed a model to predict malaria-associated ALI/ARDS using breathing patterns (enhanced pause and frequency respiration) and parasitemia as predictive criteria from mice whose cause of death was known to retrospectively diagnose the sacrificed mice as likely to die of ALI/ARDS as early as 7 days after infection. Using this method, we showed increased VEGF levels and increased lung permeability in mice predicted to die of ALI/ARDS. This proposed method for accurately identifying mice suffering from ALI/ARDS before death will enable the use of this model to study the pathogenesis of this disease.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ São Paulo, Inst Ciencias Biomed, Dept Imunol, BR-05508900 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, BR-09972270 Diadema, SP, BrazilUniv São Paulo, Inst Med Trop São Paulo, BR-05403000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Exatas & Terra, BR-09972270 Diadema, SP, BrazilUniv São Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05508000 São Paulo, BrazilUniv São Paulo, Fac Med Vet & Zootecn, Dept Cirurgia, BR-05508270 São Paulo, BrazilUniv São Paulo, Fac Med Vet & Zootecn, Dept Med Vet Prevent & Saude Anim, BR-05508270 São Paulo, BrazilUniv São Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Ciencias Biol, BR-09972270 Diadema, SP, BrazilUniversidade Federal de São Paulo, Dept Ciencias Exatas & Terra, BR-09972270 Diadema, SP, BrazilFAPESP: 2009/53256-7FAPESP: 2009/53889-0CNPq: 306668/2012-2CNPq: 470590/2009-2Web of Scienc

    Are litter, plastic and microplastic quantities increasing in the ocean?

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    Whilst both plastic production and inputs at sea have increased since the 1950s, several modelling studies predict a further increase in the coming years in these respective quantities. We compiled scientific literature on trends in marine litter, consisting largely of plastic and microplastics in the ocean, understanding that monitoring programs or assessments for these aspects are varied, frequently focusing on limited components of the marine environment in different locations, and covering a wide spectrum of marine litter types, with limited standardization. Here we discuss how trends in the amounts of litter in the marine environment can be compared with the information provided by models. Increasing amounts of plastic are found in some regions, especially in remote areas, but many repeated surveys and monitoring efforts have failed to demonstrate any consistent real temporal trend. An observed steady state situation of plastic quantities in many marine compartments and the fate and transport of plastic in the marine environment remain areas for much needed further research.info:eu-repo/semantics/publishedVersio
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